Similar studies for GEO DataSets (Select 4871) - GEO DataSets

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Items: 3

Select item 48711.

Donor lymphocyte infusion effect on bone marrow-infiltrating CD3+ T cells of patients with relapsed chronic myelogenous leukemia

Analysis of marrow-infiltrating CD3+ T cells isolated from relapsed chronic myelogenous leukemia (CML) patients following donor lymphocyte infusion (DLI) therapy. Four patients were DLI-responsive, two were DLI-nonresponsive. Results provide mechanistic insights into DLI response in relapsed CML.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 individual, 2 protocol sets

Platform:: GPL571
Series:: GSE49067
12 Samples

Download data: CEL

DataSet

Accession:: GDS4871

ID:: 4871

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000490672.

Expression data from responders/nonresponders before/after receiving DLI for relapse of CML s/p BMT

(Submitter supplied) Increasing evidence across malignancies suggests that infiltrating T cells at the site of disease are crucial to tumor control. We hypothesized that marrow-infiltrating immune populations play a critical role in response to donor lymphocyte infusion (DLI), an established and potentially curative immune therapy whose precise mechanism remains unknown. We therefore analyzed marrow-infiltrating immune populations in 29 patients (22 responders, 7 nonresponders) with relapsed chronic myelogenous leukemia who received CD4+ DLI in the pre-tyrosine kinase inhibitor era. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4871
Platform:: GPL571
12 Samples

Download data: CEL

Series

Accession:: GSE49067

ID:: 200049067

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000115653.

Discovery of the targets of the immune response to chronic myeloid leukemia in 3 patients using protein microarrays

(Submitter supplied) Three patients who had relapsed chronic myeloid leukemia after allogeneic bone marrow transplant and received an immunotherapeutic intervention (donor lymphocyte infusion, or DLI) without further treatment were studied. The binding of serum immunoglobulins to proteins after immunotherapy was compared to before in two patients using Invitrogen ProtoArrays from a single lot. For a third patient, comparison was made between two timepoints after immunotherapy against one timepoint before using Invitrogen ProtoArrays from a separate lot. more...