GEO DataSets

Analysis of bone marrow hematopoietic cells in chronic myeloid leukemia (CML) patients one month after imatinib mesylate (IM) therapy. CML is caused by expression of the BCR/ABL fusion oncogene. Results provide insight into the molecular consequences of IM blockade of oncoprotein Bcr-Abl in CML.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 10 age, 10 gender, 10 individual, 3 protocol sets

Platform:

GPL570

Series:

GSE33075

27 Samples

Download data: CEL

(Submitter supplied) Background: Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. It is well known that CML cells are genetically unstable. However, the mechanisms by which these cells acquire genetic alterations are poorly understood. Imatinib mesylate (IM) is the standard therapy for newly diagnosed CML patients. IM targets the oncogenic kinase activity of BCR-ABL. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4869

Platform:

GPL570

27 Samples

Download data: CEL

(Submitter supplied) purified CD34+ cells from bone marrow of imatinib-treated patients were compared to those of healthy donors Keywords = CML Keywords = CD34+ cells Keywords = imatinib Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS838

Platform:

GPL201

14 Samples

Download data: CEL

Comparison of purified bone marrow CD34+ cells from imatinib-treated chronic myelogenous leukemia (CML) patients and healthy donors.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL201

Series:

GSE1418

14 Samples

Download data: CEL