GEO DataSets

Analysis of cecum from master circadian regulator Clock mutants infected with S. Typhimurium at two circadian times (10am and 10pm). Clock mutants infected at night exhibited higher inflammation. Results provide insight into the role of the circadian clock in the host immune response to infection.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 infection, 2 time sets

Platform:

GPL6246

Series:

GSE46356

25 Samples

Download data: CEL

(Submitter supplied) To adapt the lives of organisms to the day-night cycle, evolution has built a complex machinery, whose molecular components are able to anticipate and drive changes in organism behavior and metabolism. A mutual bidirectional interaction exists between circadian abnormalities and development of diseases. Microarrays were used to determine whether circadian regulation occurs at the transcriptional level in response to Salmonella Typhimurium infection.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4622

Platform:

GPL6246

25 Samples

Download data: CEL

(Submitter supplied) Salmonella enterica serotype Typhimurium causes an acute inflammatory reaction in the cecum of streptomycin pre-treated mice. We determined global changes in gene expression elicited by serotype Typhimurium in the cecal mucosa. The gene expression profile was dominated by T cell derived cytokines and genes whose expression is known to be induced by these cytokines. Markedly increased mRNA levels of interferon (IFN-gamma), interleukin-22 (IL-22) and IL-17 were detected by quantitative real-time PCR. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

2 Samples

Download data: CEL, CHP

(Submitter supplied) BACKGROUND & AIMS: The immune system comprises an innate and an adaptive immune response to combat pathogenic agents. The human enteropathogen Salmonella enterica serovar Typhimurium invades the intestinal mucosa and triggers an early innate pro-inflammatory host gene response, which results in diarrheal disease. Several host factors are involved in the acute early response to Salmonella infection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

11 Samples

Download data: TXT

(Submitter supplied) HD11 cells were stimulated with 1 ug/ml endotoxin from ST-798 for 1, 2, 4 and 8 hours Cells were harvested at 1, 2, 4 and 8 hrs post stimulation and RNA was isolated from these cells and microarray was conducted for these RNA samples using affymetrix genechips

Organism:

Gallus gallus

Type:

Expression profiling by array

Platform:

GPL3213

20 Samples

Download data: CEL, TXT

(Submitter supplied) To understand the host transcriptional response to S. enterica serovar Choleraesuis (S. Choleraesuis), the first generation Affymetrix porcine GeneChip® was used to identify differentially expressed genes in the mesenteric lymph nodes responding to infection at acute (8 hours (h), 24h, 48h post-inoculation (pi)) and chronic stages (21 days (d) pi) The objectives of this study were to identify and examine the stereotypical gene expression response within the host mesenteric lymph nodes to S. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

15 Samples

Download data: CEL, EXP

(Submitter supplied) Salmonella species infect many vertebrate species, and pigs colonized with Salmonella enterica serovar Typhimurium (ST) are usually asymptomatic, making detection of these Salmonella-carrier pigs difficult. The variable fecal shedding of this gram-negative bacteria in such pigs is an important cause of foodborne illness and zoonotic disease. To investigate gene pathways and biomarkers associated with the variance in Salmonella shedding following experimental inoculation, we have initiated the first analysis of the whole blood transcriptional response induced by Salmonella. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Dataset:

GDS4246

Platform:

GPL3533

20 Samples

Download data: CEL

Analysis of peripheral blood from Salmonella enterica serovar Typhimurium (ST)-inoculated animals differing in Salmonella shedding phenotype at 0 and 2 days post-inoculation (dpi) . Fecal shedding of asymptomatic, Salmonella-carriers can lead to foodborne illness.

Organism:

Sus scrofa

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 10 individual, 2 time sets

Platform:

GPL3533

Series:

GSE27000

20 Samples

Download data: CEL

(Submitter supplied) RNA from in vitro grown Salmonella typhimurium is compared with RNA extracted from Salmonella typhimurium from infected chick caecums using a common DNA reference. Keywords: Disease state analysis, infected versus uninfected, common reference

Organism:

Salmonella enterica subsp. enterica serovar Typhimurium

Type:

Expression profiling by array

Platform:

GPL6439

8 Samples

Download data: GPR

(Submitter supplied) Objective of the study is to find out the differentially regulated genes in Salmonella typhimurium subjected to H2O2 stress. Gene expression profiling was carried out using Agilent microarray platform. Keywords: H2O2 Stress

Organism:

Salmonella enterica subsp. enterica serovar Typhimurium

Type:

Expression profiling by array

Platform:

GPL6973

4 Samples

Download data: TXT

(Submitter supplied) Part of a study to determine the impact of genome evolution on host adaptation of a group of Salmonella Typhimurium. The experiment is designed to determine the impact of culture at elevated temperature on gene experssion.

Organism:

Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; Salmonella enterica subsp. enterica serovar Typhimurium

Type:

Expression profiling by array

Platform:

GPL17242

12 Samples

Download data: TXT

(Submitter supplied) We used microarrays to detail the global programme of gene expression of the mouse colon responses to Salmonella (SL1344 and SB1117) infection at the early phase (8 hours) and the late phase (4 days). We specifically examined the the differentillay gene expression profiles in mouse colon when it responded to pathogenic Salmonella stain SL1344 (with AvrA expression) or SB1117 (without AvrA expression).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

18 Samples

Download data: CEL, CHP

(Submitter supplied) These microarrays were performed for use in a genome-wide scan for LPS-regulated genes in mouse macrophages, in order to construct a list of LPS-regulated genes for detailed interrogation on custom microarrays (see GSE19490 for custom array analysis).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4055

11 Samples

Download data: TXT

(Submitter supplied) These microarrays were performed for use in a genome-wide scan for LPS-regulated genes in human monocyte-derived macrophages, in order to construct a list of LPS-regulated genes for detailed interrogation on custom microarrays (see GSE19482 for custom array analysis).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

10 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

4 related Platforms

61 Samples

Download data: TXT

(Submitter supplied) Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing inter-species differences in the transcriptional responses of primary human and mouse macrophages to the TLR4 agonist, LPS. Using a custom platform permitting cross-species interrogation coupled with deep sequencing of mRNA 5’ ends, we identified extensive divergence in LPS-regulated orthologous gene expression between humans and mice (24% of orthologs, http://www.macgate.qfab.org). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL9802

24 Samples

Download data: TXT

(Submitter supplied) Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing inter-species differences in the transcriptional responses of primary human and mouse macrophages to the TLR4 agonist, LPS. Using a custom platform permitting cross-species interrogation coupled with deep sequencing of mRNA 5’ ends, we identified extensive divergence in LPS-regulated orthologous gene expression between humans and mice (24% of orthologs, http://www.macgate.qfab.org). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9801

16 Samples

Download data: TXT

(Submitter supplied) 60-mer spotted oligonucleotide probes. Protocol: See manufacturer's website (www.agilent.com).

Organism:

Mus musculus

2 Series

24 Samples

Download data

(Submitter supplied) 60-mer spotted oligonucleotide probes. Protocol: See manufacturer's website (www.agilent.com).

Organism:

Homo sapiens

2 Series

16 Samples

Download data

(Submitter supplied) To identify bacterial transcripts that may be associated with type I IFN production in Salmonella enterica subsp typhimurium (SL1344) infected macrophages we transformed macrophages with an ISRE-GFP reporter construct and sorted separate populations of GFP positive and GFP negative infected macrophages. We then did whole transcriptome profiling, collecting both host and bacterial transcripts, for differential expression analysis

Organism:

Mus musculus; Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL19729 GPL17021

9 Samples

Download data: TXT