GEO DataSets

Analysis of lung from C57BL/6J females up to 24hrs post-infection with mutant S. aureus deficient in alpha-hemolysin (Hla). Hla is a pore-forming cytotoxin. Results provide insight into molecular mechanisms underlying the host response to Hla in the context of S. aureus infection.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 infection, 2 time sets

Platform:

GPL1261

Series:

GSE38053

18 Samples

Download data: CEL

(Submitter supplied) Staphylococcus aureus pneumonia causes significant morbidity and mortality. Alpha-hemolysin (Hla), a pore-forming cytotoxin of S. aureus, has been identified through animal models of pneumonia as a critical virulence factor that induces lung injury. In spite of considerable molecular knowledge of how this cytotoxin injures the host, the precise host response to Hla in the context of infection remains poorly understood. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4582

Platform:

GPL1261

18 Samples

Download data: CEL

(Submitter supplied) The Staphylococcus aureus Panton Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. more...

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL4653

12 Samples

Download data: TXT

(Submitter supplied) Microarray expression profiling of S. aureus lavaged from murine lungs after residence times between 30 minutes and 6 hours compared to post-exponential phase or early log phase growth in Luria-Betani broth.

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL4047

21 Samples

Download data: CEL

(Submitter supplied) Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host’s inflammatory response to the pathogen represents a potential tool to improve upon current diagnostics. The hypothesis of this study is that the host responds differently to S. aureus than to E. coli infection in a quantifiable way, providing a new diagnostic avenue. more...

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL1261 GPL571

321 Samples

Download data: CEL, CHP