GEO DataSets

Analysis of lung at 28 wk following subchronic silica inhalation exposure to occupationally relevant doses and particle sizes of aerosolized silica. Results provide insight into molecular events associated with chronic silicosis.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL1355

Series:

GSE29110

6 Samples

Download data: CEL

(Submitter supplied) Silicosis, a fibrotic granulomatous lung disease, may occur through accidental high-dose or occupational inhalation of silica, leading to acute/accelerated and chronic silicosis, respectively. While chronic silicosis has a long asymptomatic latency, lung inflammation and apoptosis are hallmarks of acute silicosis. In animal models, histiocytic granulomas develop within days after high-dose intratracheal silica instillation. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4579

Platform:

GPL1355

6 Samples

Download data: CEL

(Submitter supplied) Identification of molecular target(s) and mechanism(s) of silica-induced pulmonary toxicity is important for the intervention and/or prevention of diseases associated with occupational exposure to crystalline silica. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 h/day, 5 days) and global gene expression profile was determined in the lungs by microarray analysis at 1, 2, 4, 8, and 16 weeks following termination of silica exposure. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

60 Samples

Download data: TXT

(Submitter supplied) Gene expression profiling of the rat lung following intratracheal instillation with single-wall carbon nanotubes (SWCNTs) was employed to gain insights into these molecular events. We attempted to characterize time-dependent changes in the gene expression until 754 days after intratracheal instillation with SWCNTs suspensions at 0.2 mg (L-SWCNT) and 0.4 mg (H-SWCNT) injected dose per rat, and to identify the shift from the acute-phase to the chronic-phase phase on the basis of evaluation at the molecular level.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

21 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL6947 GPL6101

80 Samples

Download data

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

10 Samples

Download data: TXT

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

10 Samples

Download data: TXT

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

10 Samples

Download data: TXT

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

20 Samples

Download data: TXT

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

10 Samples

Download data: TXT

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

20 Samples

Download data: TXT