GEO DataSets

Analysis of diabetogenic CD8+ G9C8 clone cells and transgenic NOD CD8 T cells. The clone and transgenic T cells display differences in their ability to kill β cells and induce disease in vivo. Results provide insight into the molecular basis of such differences between the two sets of CD8 T cells.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell type sets

Platform:

GPL1261

Series:

GSE31726

5 Samples

Download data: CEL, CHP

(Submitter supplied) Diabetogenic CD8+ G9C8 clone cells and the T cells from a transgenic mouse bearing the same TCR as the clone, displayed differences in their ability to induce disease in vivo.Microarray analysis was done to identify the molecular basis for such differences between the two sets of CD8 T cells. Microarray analysis was done to identify the molecular basis for such differences between the two sets of CD8 T cells

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4398

Platform:

GPL1261

5 Samples

Download data: CEL, CHP

(Submitter supplied) In type 1 diabetes (T1D) autoreactive CD8 T cells infiltrate pancreatic islets and destroy insulin-producing β cells. Progression to T1D onset is a chronic process, which suggests that the effector activity of β-cell autoreactive CD8 T cells needs to be maintained throughout the course of disease development. The mechanism that sustains diabetogenic CD8 T cell effectors during the course of T1D progression has not been completely defined. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

2 Samples

Download data: MTX, TSV