GEO DataSets

Analysis of basal ganglia, frontal cortex, and white matter from HIV patients with HIV-associated dementia (HAD) or HAD plus HIV encephalitis (HIVE). Results provide insight into molecular events of neurological impairment and inflammation associated with HIV infection in different brain regions.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 disease state, 3 tissue sets

Platform:

GPL570

Series:

GSE35864

72 Samples

Download data: CEL

(Submitter supplied) Finding the differences in gene expression in three regions of the brain, basal ganglia, white matter, and frontal cortex, in normal, HIV infected, HIV infected with neurocognitive impairment, and HIV infected with both neurocognitive impairment and encephalitis patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4358

Platform:

GPL570

72 Samples

Download data: CEL

(Submitter supplied) The neurodegenerative process in HIV encephalitis (HIVE) is associated with extensive damage to the dendritic and synaptic structure that often leads to cognitive impairment. Several mechanisms might be at play, including release of neurotoxins, oxidative stress and decreased activity of neurotrophic factors. Furthermore, HIV-mediated dysregulation of genes involved in neuronal maintenance might play an important role. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1726

Platform:

GPL8300

28 Samples

Download data

Analysis of brain frontal cortex of HIV-seropositive patients with HIV encephalitis (HIVE). HIVE affects >40% of AIDS patients, promoting neurodegeneration and cognitive impairment. Results suggest HIV-mediated dysregulation of genes involved in neuronal maintenance might play an important role.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL8300

Series:

GSE3489

28 Samples

Download data

(Submitter supplied) Antiretroviral therapy (ART) has reduced morbidity and mortality in HIV infection; however HIV-1-associated neurocognitive disorders (HAND) persist despite treatment. We used microarray analysis in post-mortem brain tissues to determine ART effectiveness in the brain and to identify molecular signatures of HAND under ART.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4231

Platform:

GPL570

35 Samples

Download data: CEL

Analysis of postmortem brain of ART-treated, HIV-1-associated neurocognitive disorders (HAND) patients. ART reduces morbidity and mortality in HIV infection, but HAND persist despite treatment. Results provide insight into ART effectiveness in brain and into molecular signatures of HAND under ART.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 disease state sets

Platform:

GPL570

Series:

GSE28160

35 Samples

Download data: CEL

(Submitter supplied) Analysis of HIV-associated neurocognitive disorder (HAND) in peripheral monocytes at the gene expression level. The hypothesis tested in the present study was that monocyte gene expression would be predictive of HAND. Results provide information of the associations between monocytes and global neurocognitive function.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

248 Samples

Download data: TXT