GEO DataSets

Analysis of hippocampus of aged F344 males fed a thiazolidinedione (TZD) pioglitazone-containing diet. TZDs have benefits in age-related conditions such as type 2 diabetes mellitus and Alzheimer's disease. Results provide insight into PIO's potentially beneficial actions in normal aging.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 age, 2 agent sets

Platform:

GPL1355

Series:

GSE20219

29 Samples

Download data: CEL

(Submitter supplied) Background: Thiazolidinediones (TZDs) activate peroxisome proliferator-activated receptor gamma (PPARgamma) and are used clinically to help restore peripheral insulin sensitivity in Type 2 diabetes (T2DM). Interestingly, long-term treatment of mouse models of Alzheimer’s disease (AD) with TZDs also has been shown to reduce several well-established brain biomarkers of AD including inflammation, oxidative stress and Abeta accumulation. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4019

Platform:

GPL1355

29 Samples

Download data: CEL

(Submitter supplied) Thiazolidinediones (TZDs) are agonists at peroxisome proliferator-activated gamma-type (PPAR-y) receptors and are used clinically for the treatment of type 2 diabetes where they have been shown to reestablish insulin sensitivity, improve lipids profile, and reduce inflammation. Recent work also suggests that TZDs may be beneficial in Alzheimer's disease (AD), ameliorating cognitive decline early in the disease process. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4413

Platform:

GPL1261

16 Samples

Download data: CEL

Analysis of hippocampus from 10 month-old, triple-transgenic AD females treated with the thiazolidinedione pioglitazone (PIO) for 14 weeks. TZDs exert cognitive benefits early in the AD process. Results provide insight into molecular mechanisms underlying the neuroprotective role of PIO in AD.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL1261

Series:

GSE32536

16 Samples

Download data: CEL

(Submitter supplied) We report the results of RNA-seq analysis on 5 month old wildtype and liver specific PPARg knockout male mice, fed control-diet or high fat-diet supplemented with Pio or vehicle from age 2-5 months

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21493

40 Samples

Download data: XLS

(Submitter supplied) We report the results of RXR ChIP-Seq on 2 month old wildtype and liver specific PPARg knockout mice, fed control-diet or high fat-diet supplemented with Pio or vehicle for 12 weeks

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL21493

80 Samples

Download data: NARROWPEAK, TXT