GEO DataSets

Analysis of insulinoma cell line CRI-G1-RR and subclonal line CRI-G1-RS. CRI-G1-RS is more susceptible to cell death induced by mitochondrial toxins such as rotenone and more vulnerable to direct oxidative stress. Results provide insight into the molecular basis for this vulnerability.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 cell line sets

Platform:

GPL1355

Series:

GSE19948

12 Samples

Download data: CEL, CHP

(Submitter supplied) BACKGROUND: Many age-associated disorders (including diabetes, cancer, and neurodegenerative diseases) are linked to mitochondrial dysfunction, which leads to impaired cellular bioenergetics and increased oxidative stress. However, it is not known what genetic and molecular pathways underlie differential vulnerability to mitochondrial dysfunction observed among different cell types. METHODOLOGY/PRINCIPAL FINDINGS: Starting with an insulinoma cell line as a model for a neuronal/endocrine cell type, we isolated a novel subclonal line (named CRI-G1-RS) that was more susceptible to cell death induced by mitochondrial respiratory chain inhibitors than the parental CRI-G1 line (renamed CRI-G1-RR for clarity). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4014

Platform:

GPL1355

12 Samples

Download data: CEL, CHP

(Submitter supplied) Due to the limited expression of several antioxidant enzymes, β-cells are highly vulnerable to high ROS levels, which can lead to the reduction of functional β-cell mass. During early postnatal ages, both human and rodent β-cells go through a burst of proliferation that quickly declines with age. Here we discovered that the expression of the master antioxidant regulator, Nrf2, is increased during this postnatal burst of β-cell proliferation in humans. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

7 Samples

Download data: TXT

(Submitter supplied) We performed a broad-spectrum microarray analysis using mRNA from 3 NL and 5 DS astrocyte cultures. The microarray output was validated for several genes To explore the relation between gene expression and potential oxidative stress in DS samples, we also evaluated the transcription profile in NL astrocytes subjected to mild oxidative stress (50µM H2O2 for 24 hr).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

16 Samples

Download data: TXT