GEO DataSets

Analysis of small intestine (proximal, middle, distal) mucosal cells of C57BL/6J males fed high-fat diets differing in Ca concentration. High-Ca (150mmol/kg) stimulates fecal fat and bile acid excretion. Results provide insight into role of dietary Ca on development of obesity or insulin resistance.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 3 tissue sets

Platform:

GPL1261

Series:

GSE18581

6 Samples

Download data: CEL, EXP

(Submitter supplied) There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3831

Platform:

GPL1261

6 Samples

Download data: CEL, EXP

(Submitter supplied) We studied the effect of dietary fat type, varying in polyunsaturated/saturated fatty acid ratio's (P/S) on development of metabolic syndrome. C57Bl/6J mice were fed purified high-fat diets (45E% fat) containing palm oil (HF-PO; P/S 0.4), olive oil (HF-OO; P/S 1.1) or safflower oil (HF-SO; P/S 7.8) for 8 weeks. A low-fat palm oil diet (LF-PO; 10E% fat) was used as a reference. Additionally, we analyzed diet-induced changes in gut microbiota composition and mucosal gene expression. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4339

Platform:

GPL1261

9 Samples

Download data: CEL

Analysis of small intestine divided into 3 equal parts along the proximal to distal axis (SI 1, SI 2, SI 3) from C57Bl/6J males fed high-fat diets varying in polyunsaturated/saturated fatty acid ratios (P/S). Results provide insight into role of dietary fat type on development of metabolic syndrome.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 agent, 3 tissue sets

Platform:

GPL1261

Series:

GSE18586

9 Samples

Download data: CEL

(Submitter supplied) An 8-week high fat palm oil diet causes obesity and insulin resistance in C57BL/6J mice, but induces only small changes in the muscle transcriptome. Introduction: The metabolic syndrome (MS) is a cluster of metabolic abnormalities linked to an increased risk of type 2 diabetes and cardiovascular diseases. Two major characteristics of the MS are obesity and insulin resistance. In the present study we investigated the effect of obesity and insulin resistance on the mouse muscle transcriptome. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4015

Platform:

GPL7546

30 Samples

Download data: CEL

Analysis of skeletal muscle of C57BL/6J males fed a high fat diet (HFD) for 8 weeks to induce obesity and insulin resistance. Results provide insight into the molecular mechanisms underlying the development of diet-induced obesity and insulin resistance.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 growth protocol, 2 time sets

Platform:

GPL7546

Series:

GSE17576

30 Samples

Download data: CEL

(Submitter supplied) Analysis of effect of luteolin on lipid metabolism at gene expression level. The hypothesis tested in the present study was that luteolin treatment with obesogenic diet suppressed the hepatic lipogenesis pathways. Conversely, in adipose tissue, luteolin stimulated the lipogenesis pathway and it also simultaneously increased the expression of genes controlling lipolysis and TCA cycle. Results provide important information about the effect on diet-induced obesity and its metabolic complications.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

18 Samples

Download data: TXT

(Submitter supplied) Excessive intake of dietary fat is known to be a contributing factor in the development of obesity. In this study, we determined the dose-dependent effects of dietary fat on the development of this metabolic condition with a focus on changes in gene expression in the small intestine. C57BL/6J mice were fed diets with either 10, 20, 30 or 45 energy% (E%) derived from fat for four weeks (n=10 mice/diet). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7440

120 Samples

Download data: CEL

(Submitter supplied) Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. To gain more insight in the role of the small intestine in the etiology of these metabolic disorders, a microarray study was performed on small intestines (SI) of C57BL/6J mice that were fed a high fat diet mimicking the fatty acid composition of a Western-style human diet. The mice became obese and developed dietary fat-induced glucose intolerance. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3357

Platform:

GPL1261

18 Samples

Download data: CEL, EXP

Analysis of small intestines of male C57BL/6J rodents fed a powdered high-fat purified diet for up to 8 weeks. Diet contributes to obesity and insulin resistance (IR) development. Results provide insight into the molecular mechanisms underlying dietary fat-induced obesity and IR pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 time, 3 tissue sets

Platform:

GPL1261

Series:

GSE8582

18 Samples

Download data: CEL, EXP

(Submitter supplied) The effect of dietary calcium and dairy proteins on adipose tissue gene expression profile in diet induced obesity Keywords: disease state analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

4 Samples

Download data: CEL

(Submitter supplied) To investigate the role of PexRAP/ADHAPR in adipose tissue, we use adiponectin-driven Cre recombinase to delete Dhrs7b, the gene which encodes PexRAP/ADHAPR, from all adipose depots. This study assays gene expression in subcutaneous adipose tissue (iWAT) of 8 week old chow-fed male mice.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

10 Samples

Download data: CSV

(Submitter supplied) While the phenomenon linking the early nutritional environment to disease susceptibility exists in many mammalian species, the underlying mechanisms are unknown. We hypothesized that nutritional programming is a variable quantitative state of gene expression, fixed by the state of energy balance in the neonate, that waxes and wanes in the adult animal in response to changes in energy balance. We tested this hypothesis with an experiment, based upon global gene expression, to identify networks of genes in which expression patterns in inguinal fat of mice have been altered by the nutritional environment during early post-natal development. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2995

45 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

16 Samples

Download data: CEL

(Submitter supplied) By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body is still under debate. Young (4 months) and old (21 months) male C57BL/6J mice were fed a control low-fat (10E%) or a high-fat diet (45E%) for 2 weeks. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

12 Samples

Download data: CEL

(Submitter supplied) By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body is still under debate. Young (4 months) and old (21 months) male C57BL/6J mice were fed a control low-fat (10E%) or a high-fat diet (45E%) for 2 weeks. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

4 Samples

Download data: CEL