GEO DataSets

Analysis of FIH-null large T antigen-immortalized murine embryonic fibroblasts (MEFs) grown under normoxic conditions. von Hippel-Lindau tumor suppressor gene (VHL)-null and VHL/FIH-null mutants were also examined. Results provide insight into the role of FIH as an essential regulator of metabolism.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 genotype/variation sets

Platform:

GPL1261

Series:

GSE20335

8 Samples

Download data: CEL

(Submitter supplied) Microarrays were used to examine the genome-wide expression in FIH null, VHL null and VHL/FIH double null MEFs. We used these data to analyze how deletion of FIH or VHL alone affects gene expression and if VHL and FIH have synergistic effects and differential selectivity on regulating gene expression.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3769

Platform:

GPL1261

8 Samples

Download data: CEL

(Submitter supplied) T cells must adapt to variations in tissue microenvironments; these adaptations include the degree of oxygen availability. The hypoxia-inducible factor (HIF) transcription factors control much of this adaptation, and thus regulate many aspects of T cell activation and function. The HIFs are in turn regulated by oxygen-dependent hydroxylases: both the prolyl hydroxylases (PHDs) which interact with the VHL tumor suppressor and control HIF turnover, and the asparaginyl hydroxylase known as the Factor inhibiting HIF (FIH), which modulates HIF transcriptional activity. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21626

16 Samples

Download data: TXT

(Submitter supplied) Factor-inhibiting HIF (FIH) is an asparagine hydroxylase that acts on hypoxia-inducible factors (HIFs) to control cellular adaptation to hypoxia. FIH is expressed in several tumor types, but its impact in tumor progression remains largely unexplored. We observed that FIH was expressed on human lung cancer tissue. Deletion of FIH in mouse and human lung cancer cells resulted in an increased glycolytic metabolism, consistent with increased HIF activity. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

8 Samples

Download data: TXT