Similar studies for GEO DataSets (Select 3766) - GEO DataSets

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Items: 2

Select item 37661.

Inhibitor of nuclear factor kappa B kinase beta-subunit overactivity effect on skin cells

Analysis of back skin from transgenic (Tg) animals with keratinocyte-specific IKKbeta overexpression. The Tg animals present an inflammatory skin phenotype with histological features characteristic of interface dermatitis. Results provide insight into the role of IKKbeta in skin physiopathology.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE17511
4 Samples

Download data: CEL

DataSet

Accession:: GDS3766

ID:: 3766

Select item 2000175112.

Expression data from K5-IKKbeta transgenic mouse skin

(Submitter supplied) IKKbeta is a subunit of the IkB kinase (IKK) complex required for NF-kB activation in response to pro-inflammatory signals. NF-kB regulates the expression of many genes involved in inflammation, immunity and apoptosis, and also controls cell proliferation and differentiation in different tissues; however, its function in skin physiopathology remains controversial. We here report the alterations caused by increased IKKbeta activity in basal cells of the skin of transgenic mice.