GEO DataSets

Analysis of Hand2 mutant embryo hearts at 19 hpf. Hand2 is a myocardial transcription factor essential for fusion of bilateral cardiomyocyte populations moving toward the embryonic midline. Results provide insight into downstream components of the Hand2 pathway that mediates cardiac morphogenesis.

Organism:

Danio rerio

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1319

Series:

GSE23381

6 Samples

Download data: CEL

(Submitter supplied) Heart formation requires the fusion of bilateral cardiomyocyte populations as they move toward the embryonic midline. The bHLH transcription factor Hand2 is essential for cardiac fusion; however, the effector genes that execute this function of Hand2 are unknown. Here, we provide the first evidence for a downstream component of the Hand2 pathway that mediates cardiac morphogenesis. Although hand2 is expressed in cardiomyocytes, mosaic analysis demonstrates that hand2 plays a non-autonomous role in regulating cardiomyocyte movement. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS3735

Platform:

GPL1319

6 Samples

Download data: CEL

(Submitter supplied) We aim to explore the gene expression difference in control and Hand2 mutant embryos and potential mechnisam downstream of Hand2 involved in OFT epithelium regulation.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

6 Samples

Download data: XLS

(Submitter supplied) The HAND2 transcriptional regulator controls cardiac development and we uncover addition essential functions in the endothelial to mesenchymal transition (EMT) underlying cardiac cushion development in the atrioventricular canal (AVC). In Hand2-deficient mouse embryos, the EMT underlying AVC cardiac cushion formation is disrupted and we combined ChIP-Seq of embryonic hearts with transcriptome analysis of wild-type and mutants AVCs to identify the functionally relevant HAND2 target genes. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21493

7 Samples

Download data: TXT

(Submitter supplied) Our analysis identifies the direct transcriptional targets of HAND2 in mouse embryonic hearts, both ih second heart field derived structures and in the formation of the cardiac cushions

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL13112

4 Samples

Download data: WIG

(Submitter supplied) Acquisition of the lower jaw (mandible) was evolutionarily important for jawed vertebrates. In humans, syndromic craniofacial malformations often accompany jaw anomalies. Hand2 is involved in coordinating the developmental network of mandibles and the oral apparatus through Hand2-downstream genes and is therefore a major determinant of jaw identity. We used microarrays to detail the global programme of gene expression involved in mandible specification and identified distinct classes of up-regulated genes during this process.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

4 Samples

Download data: CEL, CHP

(Submitter supplied) Through analyzing RNA-seq datasets in zfpm1 mutant embryo (36hpf) and maturing heart (21 dpf), we characterized the effects of loss of zfpm1 on the transcriptomic landscape.

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23085

8 Samples

Download data: TXT

(Submitter supplied) RNAseq analysis of cloche m39 mutant zebrafish embryos and wild type siblings at 90% epiboly - tailbud stage

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15583

4 Samples

Download data: GTF, TXT

(Submitter supplied) Purpose: identifying, with RNA-seq, genes targets of Snai1b during zebrafish cardiac development. Results: we identified several differential expressed genes, in particular cytoskeletal genes. In particular, the intermediate filament gene desmin b is upregulated.

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20828

4 Samples

Download data: TXT

(Submitter supplied) We report changes in the levels of gene expression between 48hpf hearts and 56hpf hearts, the initial stages of valvulogenesis

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18413

6 Samples

Download data: TXT

(Submitter supplied) HES3 is a basic helix-loop-helix transcription factor that regulates neural stem cell renewal during development. HES3 overexpression is predictive of reduced overall survival in patients with fusion-positive rhabdomyosarcoma, a pediatric cancer that resembles immature and undifferentiated skeletal muscle. However, the mechanisms of HES3 cooperation in fusion-positive rhabdomyosarcoma are unclear and are likely related to her3/HES3’s role in neurogenesis. more...

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24995

18 Samples

Download data: TXT