GEO DataSets

Analysis of DU145 prostate cancer cells with restored miR-205 expression. miR-205 expression is lower in prostate cancer cell lines than in normal cell lines, as well as in prostate tumors than in matched normal prostate tissues. Results provide insight into the role of miR-205 in prostate cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL6104

Series:

GSE11701

8 Samples

Download data: TXT

(Submitter supplied) The study was aimed at identifying genes directly or indirectly regulated by miR-205 in the prostate. To this purpose, DU145 prostate cancer cells, which express miR-205 at very low levels, were transfected with miR-205 synthetic precursor and consequent alterations of gene expression analyzed using a microarray approach. Keywords: comparison betweed cells exposed to different miRNA precursors

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3634

Platform:

GPL6104

8 Samples

Download data: TXT

(Submitter supplied) Overexpression of miR-31 inhibits the migration and invasion ability of glioma cell. We sought to obtain the genes regulated by mir-31 in glioma cell line.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

2 Samples

Download data: CEL

(Submitter supplied) Cell cycle arrest in response to DNA damage is an important anti-tumorigenic mechanism. microRNAs (miRNAs) were shown recently to play key regulatory roles in cell cycle progression. For example, miR-34a is induced in response to p53 activation and mediates G1 arrest by down-regulating multiple cell cycle-related transcripts. Here we show that genotoxic stress promotes the p53-dependent up-regulation of the homologous miRNAs, miR -192 and miR-215. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4372

6 Samples

Download data

(Submitter supplied) We recently identified a subset of down-regulated miRNAs such as miR-145 and miR-133a in squamous cell carcinoma. Cell growth inhibitions occurred in miR-145 and miR-133a transfectants compared with the controls, suggesting that both miRNAs function as tumor suppressors. The aims of our expression studies were identification of these miRNAs target genes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

4 Samples

Download data: TXT

(Submitter supplied) We recently identified a subset of down-regulated miRNAs such as miR-145 and miR-133a in bladder cancer. Cell growth inhibitions occurred in miR-145 and miR-133a transfectants compared with the controls, suggesting that both miRNAs function as tumor suppressors. The aims of our expression studies were identification of these miRNAs target genes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

4 Samples

Download data: TXT

(Submitter supplied) Acute lymphoblastic leukemia (ALL) is an heterogeneous disease comprising several subentities that differ for both immunophenotypic and molecular characteristics. Over the years, the biologic understanding of this neoplasm has largely increased. Gene expression profiling has recently allowed to identify specific signatures for the different ALL subsets and permitted identification of pathways deregulated by a given lesion. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL570 GPL8191

39 Samples

Download data: CEL, XLS

(Submitter supplied) The estrogen-dependence of breast cancer has long been recognized, however, the role of 17β-estradiol (E2) in cancer initiation was not known until we demonstrated that it induces complete neoplastic transformation of the human breast epithelial cells MCF-10F. E2-treatment of MCF-10F cells progressively induced high colony efficiency and loss of ductulogenesis in early transformed (trMCF) cells and invasiveness in Matrigel invasion chambers. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

12 Samples

Download data: CEL

(Submitter supplied) p63, a homologue of the tumor suppressor p53, is critical for the development and maintenance of squamous epithelia. p63 is specifically expressed in the basal layers of stratified epithelial tissues, and is considered to be a specific marker for cells of this type. The role of p63 in tumorigenesis remains poorly defined. Numerous studies have highlighted the oncogenic potential of the predominant p63 isoform, ΔNp63α; however, data suggests that other p63 proteins can act as tumor suppressors or alter the metastatic potential of tumors. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2086 GDS2087 GDS2088

Platforms:

GPL570 GPL96 GPL97

14 Samples

Download data

Analysis of squamous cell lines following siRNA knockdown of the transcription factor p63, a homolog of the tumor suppressor p53. p63 encodes multiple isoforms that activate or repress transcription, and is critical for the development and maintenance of squamous epithelia.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 cell line, 2 cell type, 2 protocol sets

Platform:

GPL570

Series:

GSE4975

6 Samples

Download data

Analysis of squamous cells following siRNA knockdown of the transcription factor p63, a homolog of the tumor suppressor p53. p63 encodes multiple isoforms that activate or repress transcription, and is critical for the development and maintenance of squamous epithelia.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell line, 2 cell type, 2 protocol sets

Platform:

GPL97

Series:

GSE4975

4 Samples

Download data

Analysis of squamous cells following siRNA knockdown of the transcription factor p63, a homolog of the tumor suppressor p53. p63 encodes multiple isoforms that activate or repress transcription, and is critical for the development and maintenance of squamous epithelia.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell line, 2 cell type, 2 protocol sets

Platform:

GPL96

Series:

GSE4975

4 Samples

Download data

(Submitter supplied) To identify target genes of cancer-related microRNAs in human cancer, several cell lines (bladder cancer, prostate cancer, renal cell carcinoma, esophageal squamous cell carcinoma, and head and neck squamous cell carcinoma) were subjected to Agilent whole genome microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL13607 GPL10332

35 Samples

Download data: TXT

(Submitter supplied) We used chromatin immunoprecipitation (ChIP) in combination with human promoter microarrays to idnetify SUZ12 and H3K27me3-occupied gene promoters in prostate cancer cells and tissues. We observed a common set of SUZ12 and H3K27me3-occupied genes in LNCaP cells, and metastatic prostate cancer tissues across individuals as well as tissue types of the metastatic sites. We also found significant overlap of cancer polycomb targets with previously published embryonic stem cell polycomb targets. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

4 related Platforms

14 Samples

Download data: TXT

(Submitter supplied) The primary goal of this experiment was to determine the endogenous miRNA that are differentially expressed between prostate adenocarcinoma cells, DU-145 and prostate immortalized epithelial cells, PWR-1E. Subsequently, we performed other analysis with BLAST and in silico algorithm searches to determine the appropriate miRNA that could regulate a novel gene MIEN1.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL19283

2 Samples

Download data: TXT

(Submitter supplied) Analysis of EMTrelated gene expression levels. The hypothesis tested in the present study was that expression of mesenchymal markers was increased and expression of epithelial markers was downregulated concomitant with increased expression of stem -like cell markers in EMT cells compared with control cells. Results demostrated that overexpression of PDGF-D induced genome-wide gene expression changes which were consistent with EMT phenotype and stem cell signatures.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6884

6 Samples

Download data: TXT

(Submitter supplied) To identify which genes were regulated by CIC in human prostate cancer cell, the effect of CIC knockdown on PC3 cell transcriptome was determined

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL10999

4 Samples

Download data: DIFF

(Submitter supplied) MicroRNAs are small non-coding RNAs that regulate mRNA function. Recent studies have shown that microRNA expression is altered in tumors. We studied the expression of both microRNAs and mRNAs in 60 primary prostate tumors and 16 non-tumor prostate tissues to evaluate the involvement of microRNAs in prostate cancer. Global microRNA expression was determined in RNA isolated from fresh-frozen human tissues with a custom oligonucleotide microarray chip. more...

Organism:

Mus musculus; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL5180

76 Samples

Download data: GPR