GEO DataSets

Analysis of monocyte-derived dendritic cells infected with Chlamydia pneumonia. C. pneumonia is a human respiratory pathogen associated with various chronic diseases such as asthma and atherosclerosis. Results provide insight into the host defense response to C. pneumonia infections.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 infection sets

Platform:

GPL570

Series:

GSE12806

4 Samples

Download data: CEL

(Submitter supplied) Infection with Chlamydia pneumoniae, a human respiratory pathogen, has been associated with various chronic diseases such as asthma, coronary heart disease and importantly atherosclerosis. Possibly because the pathogen can exist in a persistent form. TNF-a has been reported to induce chlamydial persitence in epithelial cell lines, however the mechanism of TNF-a-induced persistence has not been reported. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3573

Platform:

GPL570

4 Samples

Download data: CEL

(Submitter supplied) Neutrophil granulocytes are the major cells involved in the Chlamydia trachomatis (C.trachomatis)-mediated inflammation and histopathology. A key gene in human intracellular antichlamydial defense is the tryptophan degrading enzyme indoleamine 2,3-dioxygenase (IDO), which limits the growth of the tryptophan auxotroph Chlamydia. Despite its importance, the role of IDO in the intracellular defense against Chlamydia in neutrophils has not yet been characterized. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15207

6 Samples

Download data: CEL, CHP

(Submitter supplied) We wanted to screen the expression of known and putative antichlamydial genes in vivo. As an open approach, we performed RNA sequencing of Chlamydia muriadrum infected mouse lung tissues. RNA seq revealed that a diverse set of antichlamydial genes were induced by the infection, including previously described unique human and murine genes. We further characterized the source and activity of indolamine 2,3-dioxygenase genes, previously described as key human effectors.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16173

6 Samples

Download data: TXT

(Submitter supplied) Although much is known on the transcriptional profiles of dendritic cells (DCs) during maturation, the molecular switches critical for the acquisition of a tolerogenic program by DCs are still obscure. In the present study, we explored the gene expression pattern of CD8+ DCs purified from the mouse spleen and treated with interferon (IFN)-gamma. The cytokine, indeed, potentiates the tolerogenic potential of this DC subset via induction of the immunosuppressive tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1514

Platform:

GPL81

8 Samples

Download data

Analysis of splenic CD8+ dendritic cells (DCs) rendered tolerogenic by interferon (IFN)-γ, which activates indoleamine 2,3-dioxygenase (IDO) thereby initiating immunosuppression. Results suggest the IDO-dependent tolerogenic program requires tight co-modulation of a very restricted set of genes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL81

Series:

GSE3337

8 Samples

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