GEO DataSets

Analysis of brains of nicotine-induced seizure-sensitive (alpha7 +/T) and -resistant (beta4 -/-) nicotinic acetylcholine receptor (nAChR) mutants following nicotine treatment. Results provide insight into the molecular mechanisms underlying seizures.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 genotype/variation sets

Platform:

GPL81

Series:

GSE6614

28 Samples

Download data: CEL, CHP

(Submitter supplied) Nicotine, acting through the neuronal nicotinic acetylcholine receptors (nAChR), can induce seizures in mice. We aimed to study brain transcriptional response to seizure and to identify genes whose expression is altered after nicotine-induced seizures. Whole brains of untreated mice were compared to brains one hour after seizure activity, using Affymetrix U74Av2 microaarays. Experimental groups included wild-type mice and both nicotine-induced seizures sensitive and resistant nAChR mutant mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3536

Platform:

GPL81

28 Samples

Download data: CEL, CHP

(Submitter supplied) Studies using mice with beta4 nicotinic acetylcholine receptor (nAChR) subunit deficiency (beta4-/- mice) helped reveal the roles of this subunit in bradycardiac response to vagal stimulation, nicotine-induced seizure activity and anxiety. In order to identify genes that might be related to beta4-containing nAChRs activity, we compared the mRNA expression profiles of brains from beta4-/- and wild-type mice using Affymetrix U74Avr2 microarray. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2309

Platform:

GPL81

11 Samples

Download data

Analysis of brains of beta-4 nicotinic acetylcholine receptor (nAChR) subunit null mutants. nAChRs are pentameric ion channels. Results provide insight into the molecular basis of the beta-4 subunit's role in the bradycardic response to vagal stimulation, nicotine-induced seizure, and anxiety.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL81

Series:

GSE5320

11 Samples

Download data

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) To examine irreversible changes in the developing brain following seizures, juvenile inbred mice were intraperitoneally injected with kainate and nicotine. Keywords: seizure induction

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

34 Samples

Download data: CEL

(Submitter supplied) Although global analyses of transcription factor binding provide one view of potential transcriptional regulatory networks, regulation also occurs at levels distinct from transcription factor binding. Here, we use a genetic approach to identify targets of transcription factors in yeast and reconstruct a functional regulatory network. First, we profiled transcriptional responses in S. cerevisiae strains with individual deletions of 263 transcription factors. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL3588

269 Samples

Download data

(Submitter supplied) 3H-1, 2-dithiole-3-thione (D3T), an inducer of antioxidant and phase 2 genes, is known to enhance the detoxification of environmental carcinogens, prevent neoplasia, and to elicit other protective effects. However, a comprehensive view of the regulatory pathways induced by this compound has not yet been elaborated. Fischer F344 rats were gavaged daily for 5 days with vehicle or D3T (0.3 mmol/kg). The global changes of gene expression in liver were measured with Affymetrix RG-U34A chips. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1484

Platform:

GPL85

8 Samples

Download data

Analysis of livers of animals treated with 3H-1, 2-dithiole-3-thione (D3T). D3T blocks carcinogenesis through induction of phase 2 enzymes that enhance the detoxification of xenobiotic compounds. Results provide insight into the regulatory pathways affected by D3T.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL85

Series:

GSE3173

8 Samples

Download data

(Submitter supplied) To better understand what genes are regulated by PPAR gamma, an experimental dataset was generated by microarray analysis, in duplicate, of pooled aortic mRNA isolated from adult male mice (C57BL/6J strain) treated for 21 days with a PPAR gamma agonist (rosiglitazone) or vehicle. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS859

Platform:

GPL81

4 Samples

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Analysis of aorta isolated from adult male C57BL/6J treated for 21 days with a peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist rosiglitazone or vehicle. Diminished activity of PPARgamma may play role in pathogenesis of hypertension and vascular dysfunction.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL81

Series:

GSE1011

4 Samples

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(Submitter supplied) Glycerol kinase deficiency (GKD) is an X-linked inborn error of metabolism with metabolic and neurologic crises. Liver shows the highest level of glycerol kinase (GK) activity in humans and mice. Absence of genotype-phenotype correlations in patients with GKD indicate the involvement of modifier genes, including other network partners. To understand the molecular pathogenesis of GKD, we performed microarray analysis on liver mRNA from neonatal glycerol kinase (Gyk) knockout (KO) and wild type (WT) mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1555

Platform:

GPL1261

8 Samples

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Expression profiling of livers of 4 male glycerol kinase knockout mutants. Glycerol kinase deficiency (GKD) is an X-linked inborn error of metabolism with metabolic and neurologic crises. Results provide insight into the pathogenesis of GKD.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE3843

8 Samples

Download data

(Submitter supplied) To understand the host transcriptional response to S. enterica serovar Choleraesuis (S. Choleraesuis), the first generation Affymetrix porcine GeneChip® was used to identify differentially expressed genes in the mesenteric lymph nodes responding to infection at acute (8 hours (h), 24h, 48h post-inoculation (pi)) and chronic stages (21 days (d) pi) The objectives of this study were to identify and examine the stereotypical gene expression response within the host mesenteric lymph nodes to S. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

15 Samples

Download data: CEL, EXP

(Submitter supplied) We used manual macrodissection or laser capture microdissection (LCM) to isolate tissue sections of the hippocampus area of Ras-GRF1 wild type and knockout mice brains, and analyzed their transcriptional patterns using commercial oligonucleotide microarrays. Comparison between the transcriptomes of macrodissected and microdissected samples showed that the LCM samples allowed detection of significantly higher numbers of differentially expressed genes, with higher statistical rates of significance. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2816

Platform:

GPL339

6 Samples

Download data: CEL, CHP

Analysis of laser capture microdissected hippocampi of mutants lacking Ras-GRF1. Ras-GRF-1 is a guanine nucleotide exchange factor predominantly expressed in the central nervous system of mammals. Results provide insight into role of Ras-GRF1 in neural processes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE8425

6 Samples

Download data: CEL, CHP

(Submitter supplied) This is a study of the change in gene expression in mouse kidney after feeding control (1.0% P) or low phosphate diet (0.03% P) for 3 or 5 days to normal or Hyp (X-linked hypophosphatemic) mice at 5 weeks of age. The mice were C57BL/6J. Normal wild-type mice, hemizygous Hyp (Hyp/Y) male mice, or heterozygous (Hyp/+) female mice were used. The gene is dominant, so that the two genders are equally affected with low renal retention of phosphate and severity of their bone disease. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS879

Platform:

GPL81

20 Samples

Download data

Examination of kidney from normal or X-linked hypophosphatemic (Hyp) 5 week old mice fed either control (1.0% P) or low phosphate diet (0.03% P) for 3 or 5 days. Results provide insight into mechanism of renal adaptation to low phosphate diet.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 gender, 2 genotype/variation, 4 protocol sets

Platform:

GPL81

Series:

GSE868

20 Samples

Download data

(Submitter supplied) We report a genome-wide expression analysis of cultured rat cortical neurons treated with specific pharmacological agents, a model with alterations in neuronal activity. Using the microarray approach in combination with microelectrode array (MEA) technology, we ascertained out of approximately 27,000 genes 248 activity-dependent genes, which encompass a large number of members of distinct families, including synaptic vesicle proteins, ion channels, signal transduction molecules, synaptic growth regulators, and others. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL4528

11 Samples

Download data: TXT