GEO DataSets

Analysis of splenic CD11b+ cells from animals infected with wildtype Yersinia enterocolitica (Ye) or a YopH-deficient Ye mutant. YopH is a virulence factor that inhibits phagocytosis of Ye and promotes virulence of Ye. Results provide insight into the molecular basis of YopH-mediated immune evasion.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 dose, 3 infection sets

Platform:

GPL81

Series:

GSE11189

5 Samples

Download data: CEL, CHP

(Submitter supplied) Background: Yersinia outer protein (Yop) H is a secreted virulence factor of Yersinia enterocolitica which inhibits phagocytosis of Y. enterocolitica and promotes virulence of Y. enterocolitica (Ye) in mice. The aim of this study was to address whether and how YopH affects the innate immune response against Ye in mice. Results: For this purpose mice were infected with wild type Ye (pYV+) or a YopH-deficient Ye mutant strain (DyopH). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3418

Platform:

GPL81

5 Samples

Download data: CEL, CHP

(Submitter supplied) BMDM from BAL/c and C57BL/6 BMDM were stimlated with IFN-g overnight and infected with different Yersinia strains for 3 hrs. Keywords: repeat

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1465

Platform:

GPL339

37 Samples

Download data

Analysis of bone marrow derived macrophages from resistant C57BL/6 or susceptible BALB/c animals, with or without IFN-gamma pretreatment, infected with Yersinia enterocolitica. Results provide insight into the impact of host genetic background and IFN-gamma on Y. enterocolitica infections.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 disease state, 2 genotype/variation, 3 strain sets

Platform:

GPL339

Series:

GSE2973

37 Samples

Download data

(Submitter supplied) Streptococcus pyogenes is a major causative agent of tonsillitis or pharyngitis in children, which can lead to more invasive infections and noninfectious sequellae. S. pyogenes can persist in tonsils, while one-third of children treated with antibiotics continue to shed streptococci and have recurrent infections. Mouse nasal-associated lymphoid tissue (NALT) is functionally analogous to human oropharangeal lymphoid tissues. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

16 Samples

Download data: CEL, CHP

(Submitter supplied) Infection by attaching and effacing (A/E) pathogens poses a serious threat to public health, as was highlighted by the recent outbreak of E. coli O157:H7 infection in the United States. Here, by using a murine A/E pathogen, Citrobacter rodentium, we demonstrate that C. rodentium infection is lethal to IL-22-/- mice within two weeks. IL-22, in the early phase of infection, is indispensable for preventing the invasion of bacteria through the intestinal epithelium, and thereby preventing systemic spread and mortality. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3226

Platform:

GPL2872

6 Samples

Download data: TXT

Analysis of C57BL/6 colon cultures treated with 10 ng/ml of interleukin-22 (IL-22) for 24 hours. IL-22, a member of the IL-10 family of cytokines, can induce a marked antimicrobial response in vitro. Results provide insight into the molecular basis of IL-22 induced host defense mechanisms.

Organism:

Mus musculus

Type:

Expression profiling by array, log10 ratio, 2 agent sets

Platform:

GPL2872

Series:

GSE10010

6 Samples

Download data: TXT

(Submitter supplied) Caspases regulate cell death programs in response to environmental stresses, including infection and inflammation, and are therefore critical for the proper operation of the mammalian immune system.  Caspase-8 is necessary for optimal production of inflammatory cytokines and host defense against infection by multiple pathogens including Yersinia, but whether this is due to death of infected cells or an intrinsic role of caspase-8 in TLR-induced gene expression is unknown. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

12 Samples

Download data: TXT