GEO DataSets

Analysis of small diameter branches of the saphenous artery from spontaneously hypertensive (SHR) and adrenocorticotropic hormone (ACTH)-induced hypertensive animals. The saphenous artery is a resistance artery. Results provide insight molecular mechanisms contributing to hypertension.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 2 disease state, 2 strain sets

Platform:

GPL341

Series:

GSE8051

9 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) We investigated morphometric structure and gene expression by microarray analysis in a small diameter artery, branch of the saphenous artery (a resistance artery), in representative models of renin-angiotensin system (RAS)-dependent and glucocorticoid hypertension, using the spontaneously hypertensive rat (SHR) and adrenocorticotropic hormone (ACTH)-induced hypertensive rat, respectively. Sixteen-week-old male Wistar-Kyoto (WKY) and age-matched spontaneously hypertensive rats (SHR) were used. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3074

Platform:

GPL341

9 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL15084 GPL18115

28 Samples

Download data: TXT

(Submitter supplied) Spontaneously hypertensive rats (SHR) have been used frequently as a model for human essential hypertension. However, both the SHR and its normotensive control, the Wistar Kyoto rat (WKY), consist of genetically different sublines. We tested the hypothesis that discrepant data in literature regarding the pathophysiology of vascular remodeling in hypertension result from the use of different rat sublines. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL15084

16 Samples

Download data: TXT

(Submitter supplied) Spontaneously hypertensive rats (SHR) have been used frequently as a model for human essential hypertension. However, both the SHR and its normotensive control, the Wistar Kyoto rat (WKY), consist of genetically different sublines. We tested the hypothesis that discrepant data in literature regarding the pathophysiology of vascular remodeling in hypertension result from the use of different rat sublines. more...

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL18115

12 Samples

Download data: TXT

(Submitter supplied) We examined gene expression profiles in the rat whole brains using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis of hypertension in the SHR strains, we compared the gene expression levels at 3 and 6 weeks of age, isolated 407 genes showing a more than 4-fold increase or a less than 1/4-fold decrease.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14745

18 Samples

Download data: TXT

(Submitter supplied) This study examined the renal gene expression profiles between spontaneously-hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats at a pre-hypertensive stage (3 weeks of age) and hypertensive stage (9 weeks of age). In addition, age-related changes in gene expression patterns were examined from 3 to 9 weeks in both WKY and SHR. Five to six individual kidney samples of the same experimental group were pooled together and quadruplicate hybridizations were performed on the NIEHS Rat v2.1, 2.2 and 3.0 arrays. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL1693 GPL1692 GPL1344

16 Samples

Download data

(Submitter supplied) We measured gene expression in the adrenal glands of the Spontaneously Hypertensive Rat (SHR) and Wistar-Kyoto rat (WKY) using Affymetrix RG-U34A GeneChips. All rats were aged-matched at 4-weeks. The rats were obtained from the colonies at the Univeristy of California San Diego, La Jolla, CA. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1464

Platform:

GPL85

6 Samples

Download data: CEL, EXP

(Submitter supplied) We performed Affymetrix MG-U74Av2 GeneChip experiements on mRNA from the adrenal glands of the BPH hypertensive and BPL hypotensive mouse strains. All mice were aged-matched at 5 weeks. We obtained the mice from Jackson Laboratories, Bar Harbor, ME. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1011

Platform:

GPL81

6 Samples

Download data: CEL, EXP

Comparison of adrenal gland from spontaneously hypertensive (SHR) males at 4 weeks of age, a prehypertensive stage, and normotensive Wistar-Kyoto. Results compared to gene expression in hypertensive BPH mouse model, and provides insight into mechanisms of hypertension shared across species.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL85

Series:

GSE1675

6 Samples

Download data: CEL, EXP

Expression profiling of adrenal glands from blood pressure high (BPH) males at the prehypertensive stage. BPH males examined at 5 weeks of age. Results compared to gene expression in SHR rat model, and provides insight into mechanisms of hypertension shared across species.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 strain sets

Platform:

GPL81

Series:

GSE1674

6 Samples

Download data: CEL, EXP

(Submitter supplied) Hypertension is a multifactor disease that possibly involves alterations in gene expression in hypertensive relative to normotensive subjects that are largely unknown. In this study we used high-density oligoarrays to compare gene expression profiles in cultured neurons and glia from pons and medulla oblongata of newborn spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats, a widely documented animal model of hypertension. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL2896

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14797

20 Samples

Download data: TXT

(Submitter supplied) We examined gene expression profiles in the rat mesenteric arteries using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains and treated ones: spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP), and normotensive WKYs treated with 2K1C or 1K1C, or without operation for 3 weeks at 6 weeks of age. To identify candidate genes involved in the genesis of hypertension in the SHR strains in comparison to renal hypertensive WKY, we compared the gene expression levels at 6 weeks of age, isolated genes showing a more than 4-fold increase or a less than 1/4-fold compared with WKY treated with 2K1C, 1K1C or none.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14797

20 Samples

Download data: TXT

(Submitter supplied) Closure or patency of the ductus arteriosus is a critical event in neonatal life. We aimed to identify genes that are specifically expressed in the ductus arteriosus versus (the non-closing) aorta Gene expression profiling of laser-captured microdissected cells offers the opportunity to study gene expression profiles in cells of different embryonic origin

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL17780

48 Samples

Download data: CEL