GEO DataSets

Analysis of testes at various time points up to 10 hours following subcutaneous injection of the histone deacetylase inhibitor trichostatin A (TSA). TSA treatment is followed by infertility due to the apoptosis of pachytene spermatocytes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 5 time sets

Platform:

GPL4053

Series:

GSE5448

10 Samples

Download data

(Submitter supplied) Trichostatin A (TSA) is one of the most potent reversible histone deacetylase (HDAC) inhibitors. In male mice, subcutaneous application of TSA is followed by infertility due to apoptosis of pachytene spermatocytes. To get more insight into the mechanisms underlying this phenomenon, we performed a genome-wide expression analysis of murine testes after TSA treatment. The whole genome transcriptome analysis revealed 507 significantly regulated genes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2923

Platform:

GPL4053

10 Samples

Download data

(Submitter supplied) This study compares HEPG2 cells treated with either ethanol(control) or TSA (0.5uM) for 24 hrs. Gene Expression was profiled on HU-133 plus 2.0 arrays Keywords: Treaded vs untreated

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data

(Submitter supplied) F9 cells were exposed to two different differentiating agents (retinoic acid or trichostatin A both dissolved in 100% ethonal) for 24 hrs. Control cells were exposed to ethonal for 24hrs Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1512

Platform:

GPL81

9 Samples

Download data

Analysis of embryonal carcinoma cell line F9 following treatment with all-trans retinoic acid or trichostatin A, a histone deacetylase inhibitor (HDACI). Retinoic acid and HDACIs may be critical regulators of tissue homeostatis and are being tested in clinical trials for a variety of cancers.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 agent sets

Platform:

GPL81

Series:

GSE1437

9 Samples

Download data

(Submitter supplied) In order to dtermine the role of histone actylation in gene expresssion, E. histolytica 200:NIH trophozoites were treated with the HDAC inhibitor Trichostatin A, or grown in short chain fatty acids, which have been shown to alter histone actylation patterns in Entamoeba species. Keywords: Expression

Organism:

Entamoeba histolytica

Type:

Expression profiling by array

Platform:

GPL4622

8 Samples

Download data: CEL