GEO DataSets

Analysis of livers of Fisher F344/N males at 32, 58, and 84 weeks of age. Results provide insight into age-associated changes in the capacity of the liver to metabolize xenobiotic compounds.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 3 age sets

Platform:

GPL890

Series:

GSE4270

38 Samples

Download data

(Submitter supplied) Toxicokinetic and metabolism studies are considered crucial to dose setting and interpretation of data from rodent carcinogenicity studies. The metabolism and distribution studies are usually conducted in 6 to 8 week old rodents. However cancer studies generally involve exposures from 6 weeks of age to 108 weeks or more of age. It is recognized that age-related differences in sensitivities to some xenobiotics occur in several rodent models including the rat. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2915

Platform:

GPL890

38 Samples

Download data

(Submitter supplied) In order to gain insight into the effects of aging on susceptibility to environmental toxins, we characterized the expression of xenobiotic metabolizing enzymes (XMEs) from the livers of male Brown Norway and F344 rats across the adult lifespan. To examine metabolic processes across lifespan after challenge with a xenobiotic compound, Brown Norway rats were exposed to 1.0 g/kg body weight toluene by oral gavage in corn oil (4ml/kg body weight) or corn oil alone. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

34 Samples

Download data: CEL

(Submitter supplied) Age- and sex-related susceptibility to adverse drug reactions is a key concern in understanding drug safety and disease progression. We hypothesize that the underlying suite of hepatic genes expressed at various developmental and life-cycle stages will impact susceptibility to adverse drug reactions. Thus, understanding the basal expression patterns of genes throughout the life span of the rat model species in both sexes will inform our assessments of adverse drug reactions. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

90 Samples

Download data: GPR