GEO DataSets

Analysis of cerebral cortices (CCs) and hypothalami (HYs) of animals after various durations of sleep and sleep deprivation. The CC is a neuronal target for processes that control sleep; the HY is an important site of sleep regulatory processes. Results provide insight into the function of sleep.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol, 5 time, 2 tissue sets

Platform:

GPL1261

Series:

GSE6514

90 Samples

Download data: CEL

(Submitter supplied) These studies address temporal changes in gene expression during spontaneous sleep and extended wakefulness in the mouse cerebral cortex, a neuronal target for processes that control sleep; and the hypothalamus, an important site of sleep regulatory processes. We determined these changes by comparing expression in sleeping animals sacrificed at different times during the lights on period, to that in animals sleep deprived and sacrificed at the same diurnal time. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2882

Platform:

GPL1261

90 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL