GEO DataSets

Temporal examination of ethynyl estradiol (EE) in uterus of immature, ovariectomized C57BL/6. 0.1 mg/kg EE or vehicle administered and uteri harvested at 0, 2, 8, 12, or 24 hours, or three daily doses administered and uteri harvested at 72 hours.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 agent, 6 time sets

Platform:

GPL75

Series:

GSE280

21 Samples

Download data

(Submitter supplied) Immature, ovariectomized C57BL/6 mice were treated with sesame oil (vehicle) or with 0.1 mg/kg 17-alpha-ethynylestradiol (EE) for the length of time indicated. Mice received one dose, except for the 3x24hr samples, which received 3 consecutive daily doses and were sacrificed 24hr after the final dose. Two replicates of each sample are provided. In addition, one time=0 sample is included. Keywords = uterus estrogen time mouse Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS285

Platform:

GPL75

21 Samples

Download data

(Submitter supplied) 17ß-Estradiol (E2) is well known to be associated with uterine cancer, endometriosis, and leiomyomas. Although insulin-like growth factor I (IGF-I) has been identified as a mediator of the uterotrophic effect of E2 in several studies, this mechanism is still not well understood. In the present study, identification of the genes modulated by a physiological dose of E2, in the uterus, has been done in ovariectomized mice using Affymetrix microarrays. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2638

Platform:

GPL81

6 Samples

Download data: CEL

Analysis of uteri from overiectomized animals at various lengths of time up to 24 hours following treatment with 17beta-estradiol (E2). Results provide insight into the molecular basis of the uterotrophic effect induced by a physiological dose of E2.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 6 time sets

Platform:

GPL81

Series:

GSE6219

6 Samples

Download data: CEL

(Submitter supplied) We have determined the gene expression profile induced by 17 alpha-ethynyl estradiol (EE) in Ishikawa cells, a human uterine-derived estrogen-sensitive cell line, at various doses (1 pM, 100 pM, 10 nM, and 1 microM) and time points (8, 24, and 48 h). The transcript profiles were compared between treatment groups and controls (vehicle-treated) using high-density oligonucleotide arrays to determine the expression level of approximately 38,500 human genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

75 Samples

Download data: CEL, CHP

(Submitter supplied) Characterizing estrogen-responsive genes is an essential step towards fully understanding mechanisms of estrogen action during mammary gland development and function. To catalogue these genes, sixteen prepubertal heifers were used in a 2 x 2 factorial with ovarian status (intact or ovariectomized) as the first factor and estrogen treatment as the second (control or estradiol). Heifers were ovariectomized at approximately 4.5 months of age and estrogen treatments were initiated one month later. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL3711

32 Samples

Download data: CEL

(Submitter supplied) Expression profiles in aortas isolated from mouse strains C3H.2/HeJ and C57.2Bl/6. Mice were were either on a high fat diet or normal diet for 0, 4, 10, 24, or 40 weeks. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS735

Platform:

GPL891

54 Samples

Download data

Comparison of gene expression in aortas of C57BL/6 and C3H/HeJ fed identical high fat diets at 0, 4, 8, 24, and 40 weeks. C57BL/6 has a greater tendency than C3H/HeJ to develop atherosclerotic aortic lesions when both fed identical high fat diets.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 2 growth protocol, 2 strain, 5 time sets

Platform:

GPL891

Series:

GSE1560

54 Samples

Download data

(Submitter supplied) Immature (19/20 days of age) Alpk:APfCD-1 mice were treated with arachis oil (AO) vehicle or 0.4mg/kg 17beta-estradiol (E2), via a single subcutaneous injection, and sacrificed at 1hr, 2hr, 4hr, 8hr, 24hr, 48hr, 72hr post dose. Keywords = estrogen Keywords = gene expression Keywords = microarray Keywords = phenotypic anchoring Keywords = uterus Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1058

Platform:

GPL81

42 Samples

Download data

Analysis of uteri of immature 19 to 20 day old Alpk:APfCD-1 females given a single injection of 400 ug/kg 17beta-estradiol (E2). Gene expression examined at various time points up to 72 hours following treatment. Results provide insight into mechanisms underlying E2-induced uterine growth.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 7 time sets

Platform:

GPL81

Series:

GSE2195

42 Samples

Download data