Similar studies for GEO DataSets (Select 2826) - GEO DataSets

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Items: 2

Select item 28261.

Sickle cell anemia model: brain response to naloxone

Analysis of brains of NY1DD transgenic animals treated with naloxone. The NY1DD strain is a model for sickle cell anemia. Naloxone is an opioid antagonist that possesses potent analgesic activity in NY1DD animals. Results provide insight into the mechanism of action of naloxone in this model.

Organism:: Mus musculus

Type:: Expression profiling by array, log ratio, 2 strain sets

Platform:: GPL4464
Series:: GSE6578
6 Samples

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DataSet

Accession:: GDS2826

ID:: 2826

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000065782.

Analgesia of naloxone in wild-type and NY1DD transgenic mouse model of sickle cell anemia using BMAP cDNA microarrays

(Submitter supplied) Sickle cell disease is the most common genetic disorder in African-Americans. The opioid analgesic, morphine, has long been the treatment for the severe pain associated with this disease. Here we reveal that the opioid antagonist, naloxone, possesses potent analgesic activity in two strains of sickle cell mice (NY1DD and hBERK1) and not in their respective controls (ICR-CD1 and C57BL/6J) when administered by three parenteral routes. more...