GEO DataSets

Analysis of striata from several inbred strains strains, with different opioid-related phenotypes, subjected to single and repeated morphine administrations. Results provide insight into the relationship between gene expression and behavioral response to the drug.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 protocol, 4 strain sets

Platform:

GPL1261

Series:

GSE7762

36 Samples

Download data: CEL

(Submitter supplied) Chronic opiate use produces molecular and cellular adaptations in the nervous system, leading to tolerance, physical dependence and addiction. Genome-wide comparison of morphine-induced changes in brain transcription of mouse strains with different opioid-related phenotypes provides an opportunity to discover the relationship between gene expression and behavioral response to the drug. Keywords: Drug response

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2815

Platform:

GPL1261

36 Samples

Download data: CEL

(Submitter supplied) To identify molecular effects of chronic drug treatment, heroin and methamphetamine treated animals were compared with saline treated animals at multiple time-points using microarray technology. Gene expression profile was assessed 14 h after the last dose of 1, 3, 6 or 12 days drug treatment and after 13, 15, 18 or 24 days of withdrawal.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

78 Samples

Download data: TXT

(Submitter supplied) In summary, we characterized genomic signatures of response to drugs of abuse and we found positive correlations between the drug-induced expression and various behavioral effects. These signatures are formed by two dynamically inducible transcriptional networks: (1) CREB/SRF-dependent gene pattern that appears to be related to drug-induced neuronal activity, (2) the pattern of genes controlled at least in part via release of glucocorticoids and androgens that are associated with rewarding and harmful drug effects. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3703

Platform:

GPL6105

108 Samples

Download data: TXT

Analysis of brain striata of C57BL/6J animals treated for up to 8 hours with cocaine, ethanol, heroin, methamphetamine, morphine, or nicotine. Results provide insight into the molecular mechanisms underlying addiction to different classes of drugs of abuse.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 8 agent, 4 time sets

Platform:

GPL6105

Series:

GSE15774

108 Samples

Download data

(Submitter supplied) Chronic exposure to opioids induces adaptations in brain function that lead to the formation of the behavioral and physiological symptoms of drug dependence and addiction. Genome wide analysis of molecular effects of protracted morphine or saccharin intake in C57BL/6J mice over a period of 7 months provides an opportunity to observe the alterations in the brain that accompany long-term drug addiction.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

24 Samples

Download data: TXT