Similar studies for GEO DataSets (Select 2741) - GEO DataSets

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Items: 19

Select item 27411.

TCR-alpha/beta CD8-alpha/alpha intestinal intraepithelial lymphocytes

Analysis of TCR-alpha/beta CD8-alpha/alpha intestinal intraepithelial lymphocytes (IELs). Results provide insight into the function of TCR-alpha/beta CD8-alpha/alpha IELs in the mucosal immune system.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 cell type sets

Platform:: GPL81
Series:: GSE5355
6 Samples

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DataSet

Accession:: GDS2741

ID:: 2741

Select item 2000053552.

Microarray Analysis of Murine IEL Subsets

(Submitter supplied) Mouse small intestine intraepithelial lymphocytes (IEL) that express a ab TCR and CD8aa homodimers are an enigmatic T cell subset, as their specificity and in vivo function remain to be defined. To gain insight into the nature of these cells, we performed global gene expression profiling using microarray analysis, combined with PCR and flow cytometry to determine the level of expression of selected genes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2741
Platform:: GPL81
6 Samples

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Series

Accession:: GSE5355

ID:: 200005355

Select item 2000229853.

Global expression profiling of peripheral Qa-1 class Ib-restricted CD8aa+TCRab+ regulatory T Cells reveals innate-like features: implications for immune regulatory repertoire

(Submitter supplied) To better understand the function of CD8aa Tregs, we have recently characterized several CD8aa+TCRab+ T cell clones and lines that are physiologically primed and are involved in recovery and protection from EAE (REF). In this report, we present a comparison of global gene expression patterns in CD8aa Tregs versus OT-1 CD8aa+TCRab+ T cells. The results of microarray data analysis are confirmed by real-time PCR and flow cytometry for better accuracy and phenotype expression. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE22985

ID:: 200022985

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001171224.

Gene expressions of TCRαβ+ CD8αα+ intraepithelial lymphocyte (IELs) in the small intestine with or without Rbpj gene

(Submitter supplied) cDNA microarray data of TCRαβ+ CD8αα+ IELs in the small intestine with or without Rbpj gene

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
2 Samples

Download data: TXT

Series

Accession:: GSE117122

ID:: 200117122

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001857985.

Genome-wide maps of chromatin state in mouse small intestinal intraepithelial lymphocytes.

(Submitter supplied) We performed CUT&Tag-Seq against histone H3K27me3 in mouse small intestinal TCRβ+CD8αα+ intraepithelial lymphocytes (IELs) of wild-type mice to analyze epigenetic modifications.

Organism:: Mus musculus

Type:: Other

Platform:: GPL24247
1 Sample

Download data: BIGWIG

Series

Accession:: GSE185798

ID:: 200185798

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001544446.

Kdm6b is required for the maturation and function of intestinal TCRβ+CD8αα+ intraepithelial lymphocytes

(Submitter supplied) To under the role of Kdm6b in the regulation of intestinal TCRβ+CD8αα+ intraepithelial lymphocytes (IELs), Kdm6b was conditionally deleted in mouse T cells. Small intestinal TCRβ+CD8αα+ IELs were sorted by flow cytometry and RNA-seq was conducted to identify the differentially expressed genes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: TXT

Series

Accession:: GSE154444

ID:: 200154444

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001862917.

Single-cell ATAC of WT thymic IEL precursors (IELp)

(Submitter supplied) To examine the chromatin accessibility of IELp, single cell epigenomic analysis of IELp from control mice (Cd4 Cre–Lrffl/fl) were determined by scATACseq

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL30172
2 Samples

Download data: CSV, H5, TBI, TSV

Series

Accession:: GSE186291

ID:: 200186291

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001861648.

Single-cell Gene expression of WT CD8aa IEL and LRF-deficient CD8aa splenocytes

(Submitter supplied) To examine how the cluster composition of CD8aa IEL and their transcriptomic signatures were affected by LRF disruption, single-cell gene expression of CD8aa IEL from control (Cd4 Cre–Lrffl/fl) and CD8aa splenocytes from LRF KO (Cd4 Cre+Lrffl/fl ) mice were determined by scRNAseq.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
4 Samples

Download data: H5

Series

Accession:: GSE186164

ID:: 200186164

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001499939.

LRF genome-wide occupancy in CD4+ T cells

(Submitter supplied) To examine whether LRF protein could bind cis-regulatory elements in the genes that LRF regulates. We performed Chromatin immunoprecipitation followed by deep-sequencing (ChIPseq) on activated T cells using an in vivo biotinylation and streptavidin pull-down approach.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: BW

Series

Accession:: GSE149993

ID:: 200149993

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014998510.

Single-cell Gene expression of WT and LRF-deficient thymic IEL precusors (IELp)

(Submitter supplied) To examine how the cluster composition of IELp and their transcriptomic signatures were affected by LRF disruption, single-cell gene expression of IELp from control (Cd4 Cre–Lrffl/fl) and LRF KO(Cd4 Cre+Lrffl/fl )mice were determined by scRNAseq

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: H5, MTX, TSV

Series

Accession:: GSE149985

ID:: 200149985

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014994311.

Gene expression in WT and LRF-deficient thymic IEL precusors (IELp) and their progeny CD8aa IEL

(Submitter supplied) Gene expression of IELp and CD8aa IEL was determined by RNAseq

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: CSV

Series

Accession:: GSE149943

ID:: 200149943

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20019941712.

HNF4A regulation of transcription profiles in the mouse intestinal epithelial cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
22 Samples

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Series

Accession:: GSE199417

ID:: 200199417

PubMed Full text in PMC Similar studies

Select item 20019941613.

HNF4A regulation of transcription profiles in the mouse ileal and colonic epithelial cells

(Submitter supplied) Purpose: HNF4A is a highly conserved nuclear receptor that has been associated with inflammatory bowel diseases. The goal of this study is to determine and compare transcriptional regulation by HNF4A in the small intestine and large intestine in mice. Methods: Intestinal epithelial cells (IECs) were flow sorted from the ileum and colon of WT and HNF4A IEC-specific KO mice at 21~22 days old and sequenced for transcriptome. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
16 Samples

Download data: CSV

Series

Accession:: GSE199416

ID:: 200199416

PubMed Full text in PMC Similar studies

Select item 20019941514.

HNF4A regulation of transcription profiles in the mouse cecal epithelial cells

(Submitter supplied) Purpose: HNF4A is a highly conserved nuclear receptor that has been associated with inflammatory bowel diseases. The goal of this study is to determine transcriptional regulation by HNF4A in the cecal IECs.. Methods: Intestinal epithelial cells (IECs) were sorted from the ceca of young adult WT and HNF4A IEC-specific KO mice and sequenced for transcriptome. Differentially expressed genes comparing the WT and HNF4A IEC-KO were determined. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
6 Samples

Download data: CSV

Series

Accession:: GSE199415

ID:: 200199415

PubMed Full text in PMC Similar studies

Select item 20025236015.

Single cell analysis revealed that two distinct, unique CD4+ T cell subsets were increased in the small intestinal intraepithelial lymphocytes of aged mice

(Submitter supplied) Recent advances in research suggest that aging has a controllable chronic inflammatory disease aspect. Aging systemic T cells, which secrete pro-inflammatory factors, affect surrounding somatic cells, and accelerate the aging process through chronic inflammation, have attracted attention as potential therapeutic targets in aging. On the other hand, there are few reports on the aging of the intestinal immune system, which differs from the systemic immune system in many ways. more...