GEO DataSets

Analysis of lungs from 2 strains exposed to high tidal volume mechanical ventilation. Examined strains consist of one that is resistant to ventilator-associated lung injury (VALI) and another that is sensitive. Results provide insight into the genetic basis of susceptibility to VALI.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 2 strain sets

Platform:

GPL1355

Series:

GSE7041

12 Samples

Download data: CEL

(Submitter supplied) We sought to confirm the genetic influence in the development of Ventilation-Associated Lung Injury (VALI) and, in the process, identify potential candidate genes involved in the disease by integrating differential gene expression profiling on rat lungs to a traditional strain survey analysis of the parental rat strains, VALI-sensitive Brown Norway rats versus VALI-resistant Dahl Salt Sensitive rats, comparing control (under room air ventilation) versus under high tidal volume (HTV) ventilation. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2709

Platform:

GPL1355

12 Samples

Download data: CEL

(Submitter supplied) The results of this study identified a number of pathways potentially important for the amelioration of hypertension and renal injury in SS-13BN/Mcw rats, and these results generated a series of testable hypotheses related to the role of the renal medulla in the complex mechanism of salt-sensitive hypertension. Keywords: time course, microarray; 11ß-hydroxysteroid dehydrogenase; glucagon receptor; extracellular matrix; apoptosis

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3061

24 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:

GPL18694

72 Samples

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(Submitter supplied) Chromosome 2 introgression from normotensive Brown Norway (BN) rats into hypertensive Dahl salt-sensitive (SS) background (consomic S2B) reduced blood pressure (BP) and vascular inflammation under normal salt diet (NSD). We hypothesized that BN chromosome 2 contains anti-inflammatory genes that could reduce BP elevation and vascular inflammation in rats fed NSD and high salt diet (HSD). We used chromosome 2 fragment substitutions to map chromosome 2 portion associated with vascular inflammation changes and next generation sequencing (NGS) to profile microRNAs in thoracic descending aorta of SS and congenic rats fed NSD or HSD.

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL18694

36 Samples

Download data: XLSX

(Submitter supplied) Chromosome 2 introgression from normotensive Brown Norway (BN) rats into hypertensive Dahl salt-sensitive (SS) background (consomic S2B) reduced blood pressure (BP) and vascular inflammation under normal salt diet (NSD). We hypothesized that BN chromosome 2 contains anti-inflammatory genes that could reduce BP elevation and vascular inflammation in rats fed NSD and high salt diet (HSD). We used chromosome 2 fragment substitutions to map chromosome 2 portion associated with vascular inflammation changes and next generation sequencing (NGS) to profile messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs) in thoracic descending aorta of SS and congenic rats fed NSD or HSD.

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18694

36 Samples

Download data: XLSX

(Submitter supplied) Substitution of chromosome 13 from Brown Norway BN/SsNHsd/Mcw (BN/Mcw) rats into the Dahl salt-sensitive SS/JrHsd/Mcw (SS/Mcw) rats resulted in substantial reduction of blood pressure salt sensitivity in this consomic rat strain designated SSBN13. In the present study, we attempted to identify genes associated with salt-sensitive hypertension by utilizing a custom, known-gene cDNA microarray to compare the mRNA expression profiles in the renal medulla (a tissue playing a pivotal role in long-term blood pressure regulation) of SS/Mcw and SSBN13 rats on either low-salt (0.4% NaCl) or high-salt (4% NaCl, 2 wk) diets. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3076

24 Samples

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(Submitter supplied) This series contain unilateral mechanical ventilated canine lung samples. Keywords: other

Organism:

Homo sapiens; Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL96

24 Samples

Download data: CEL, EXP, RPT, TXT

(Submitter supplied) This series contain mouse and rat lung samples treated with mechanical ventilation and corresponded controls. Keywords: other

Organism:

Rattus norvegicus; Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1240 GDS1241

Platforms:

GPL85 GPL81

8 Samples

Download data: CEL, EXP

Investigation of deleterious effects of mechanical ventilation (MV) on lung gene expression in model of ventilator-induced lung injury. MV, a treatment of acute lung injury, can augment injury in some patients.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL85

Series:

GSE2368

4 Samples

Download data: CEL, EXP

Investigation of deleterious effects of mechanical ventilation (MV) on lung gene expression in model of ventilator-induced lung injury. MV, a treatment of acute lung injury, can augment injury in some patients.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL81

Series:

GSE2368

4 Samples

Download data: CEL, EXP

(Submitter supplied) Placentation differs in the BN rat strain when compared to HSD and DSS rat strains. Intrauterine trophoblast invasion is shallow and the junctional zone is underdeveloped in the BN rat. These structural differences are striking but their quantification is not conducive to high throughput analyses. In the rat, the junctional zone can be readily dissected and is more homogenous than other components of the placentation site. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

6 Samples

Download data: CEL