GEO DataSets

Analysis of retinas and hippocampi of SAMP8 and SAMP10 animals at 3 and 16 months of age. SAMP8 and SAMP10 are inbred animal models of accelerated neurological senescence. Results provide insight into the molecular mechanisms underlying neurological aging.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 disease state, 3 strain, 2 tissue sets

Platform:

GPL81

Series:

GSE6238

27 Samples

Download data: CEL

(Submitter supplied) Background: Progressive neurological dysfunction is a key aspect of human aging. Because of underlying differences in the aging of mice and humans, useful mouse models have been difficult to obtain and study. We have used gene-expression analysis and polymorphism screening to study molecular senescence of the retina and hippocampus in two rare inbred mouse models of accelerated neurological senescence (SAMP8 and SAMP10) that closely mimic human neurological aging, and in a related normal strain (SAMR1) and an unrelated normal strain (C57BL/6J). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2654

Platform:

GPL81

27 Samples

Download data: CEL

(Submitter supplied) Lifelong murine gene expression profiles in relation to chronological and biological aging in multiple organs

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL14996

90 Samples

Download data: CEL

(Submitter supplied) The mammalian brain is complex, with multiple cell types performing a variety of diverse functions, but exactly how each cell type is affected in aging remains largely unknown. Here we performed a single-cell transcriptomic analysis of young and old mouse brains. We provide comprehensive datasets of aging-related genes, pathways and ligand–receptor interactions in nearly all brain cell types. Our analysis identified gene signatures that vary in a coordinated manner across cell types and gene sets that are regulated in a cell-type specific manner, even at times in opposite directions. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

16 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL738 GPL782

1248 Samples

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(Submitter supplied) To assess the molecular changes associated with aging in different tissues of mice using cDNA microarrays to examine the transcriptomes of young, middle aged and old mice. Mice of both genders were examined in relation to the effects of age in multiple tissues. Keywords: age- and gender comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL782 GPL738

80 Samples

Download data

(Submitter supplied) To assess the molecular changes associated with aging in different tissues of mice using cDNA microarrays to examine the transcriptomes of young, middle aged and old mice. Mice of both genders were examined in relation to the effects of age in multiple tissues. Keywords: age- and gender comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL738 GPL782

80 Samples

Download data

(Submitter supplied) To assess the molecular changes associated with aging in different tissues of mice using cDNA microarrays to examine the transcriptomes of young, middle aged and old mice. Mice of both genders were examined in relation to the effects of age in multiple tissues. Keywords: age- and gender comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL782 GPL738

80 Samples

Download data

(Submitter supplied) To assess the molecular changes associated with aging in different tissues of mice using cDNA microarrays to examine the transcriptomes of young, middle aged and old mice. Mice of both genders were examined in relation to the effects of age in multiple tissues. Keywords: age- and gender comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL782 GPL738

64 Samples

Download data

(Submitter supplied) To assess the molecular changes associated with aging in different tissues of mice using cDNA microarrays to examine the transcriptomes of young, middle aged and old mice. Mice of both genders were examined in relation to the effects of age in multiple tissues. Keywords: age- and gender comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL738 GPL782

80 Samples

Download data

(Submitter supplied) To assess the molecular changes associated with aging in different tissues of mice using cDNA microarrays to examine the transcriptomes of young, middle aged and old mice. Mice of both genders were examined in relation to the effects of age in multiple tissues. Keywords: age- and gender comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL738 GPL782

76 Samples

Download data

(Submitter supplied) To assess the molecular changes associated with aging in different tissues of mice using cDNA microarrays to examine the transcriptomes of young, middle aged and old mice. Mice of both genders were examined in relation to the effects of age in multiple tissues. Keywords: age- and gender comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL782 GPL738

78 Samples

Download data

(Submitter supplied) To assess the molecular changes associated with aging in different tissues of mice using cDNA microarrays to examine the transcriptomes of young, middle aged and old mice. Mice of both genders were examined in relation to the effects of age in multiple tissues. Keywords: age- and gender comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL738 GPL782

80 Samples

Download data

(Submitter supplied) To assess the molecular changes associated with aging in different tissues of mice using cDNA microarrays to examine the transcriptomes of young, middle aged and old mice. Mice of both genders were examined in relation to the effects of age in multiple tissues. Keywords: age- and gender comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL782 GPL738

72 Samples

Download data

(Submitter supplied) To assess the molecular changes associated with aging in different tissues of mice using cDNA microarrays to examine the transcriptomes of young, middle aged and old mice. Mice of both genders were examined in relation to the effects of age in multiple tissues. Keywords: age- and gender comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL738 GPL782

80 Samples

Download data

(Submitter supplied) To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged and old mice. Mice of both genders were examined as well as the effects of their placement on either caloric restricted (CR) or ad libitum (AL) diets. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL782

67 Samples

Download data

(Submitter supplied) To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged and old mice. Mice of both genders were examined as well as the effects of their placement on either caloric restricted (CR) or ad libitum (AL) diets. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL782

65 Samples

Download data

(Submitter supplied) To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged and old mice. Mice of both genders were examined as well as the effects of their placement on either caloric restricted (CR) or ad libitum (AL) diets. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL782

67 Samples

Download data

(Submitter supplied) To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged and old mice. Mice of both genders were examined as well as the effects of their placement on either caloric restricted (CR) or ad libitum (AL) diets. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL782

67 Samples

Download data

(Submitter supplied) To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged and old mice. Mice of both genders were examined as well as the effects of their placement on either caloric restricted (CR) or ad libitum (AL) diets. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL782

66 Samples

Download data