Similar studies for GEO DataSets (Select 258) - GEO DataSets

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Items: 20

Select item 2581.

Juvenile dermatomyositis muscle profile (HuGeneFL)

Examination of skeletal muscle from juvenile dermatomyositis (JDM) patients, a common pediatric inflammatory myopathy. Muscle biopsies processed singly or in mixed groups of two. Patients genotyped for TNFalpha which is associated with prolonged disease.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 8 specimen sets

Platform:: GPL80
Series:: GSE493
10 Samples

Download data: CEL

DataSet

Accession:: GDS258

ID:: 258

Select item 2000004932.

Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis

(Submitter supplied) Juvenile dermatomyositis (JDM), the most common pediatric inflammatory myopathy, is a systemic vasculopathy affecting young children. Epidemiology studies documenting an antecedent illness in the 3 mo before the first definite symptom (rash and/or weakness) of JDM are supported by immunologic data that suggest that the disease pathophysiology is Ag driven. The purpose of this study was to compare the gene expression profiles in muscle biopsies of four untreated DQA1*0501(+) JDM children with profiles from children with a known necrotizing myopathy (Duchenne muscular dystrophy), as well as an in vitro antiviral model (NF90), and healthy pediatric controls. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS215 GDS258
Platforms:: GPL246 GPL80
14 Samples

Download data: CEL

Series

Accession:: GSE493

ID:: 200000493

Select item 2153.

Juvenile dermatomyositis muscle profile (MuscleChip)

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 specimen sets

Platform:: GPL246
Series:: GSE493
4 Samples

Download data: CEL

DataSet

Accession:: GDS215

ID:: 215

Select item 2000119714.

Skeletal muscles of untreated children with juvenile dermatomyositis

(Submitter supplied) Background :To evaluate the impact of the duration of chronic inflammation on gene expression in skeletal muscle biopsies (MBx) from untreated children with juvenile dermatomyositis (JDM) and identify genes and biological processes associated with the disease progression, expression profiling data from 16 girls with active symptoms of JDM greater or equal to 2 months were compared with 3 girls with active symptoms less than 2 months. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3417
Platform:: GPL96
23 Samples

Download data: CEL, CHP

Series

Accession:: GSE11971

ID:: 200011971

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 34175.

Untreated juvenile dermatomyositis muscle biopsies

Analysis of skeletal muscle biopsies from untreated girls with active symptoms of juvenile dermatomyositis (JDM) less than 2 months or greater than 2 months. Results provide insight into the impact of the duration of chronic inflammation on gene expression in muscle of untreated children with JDM.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 disease state sets

Platform:: GPL96
Series:: GSE11971
23 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3417

ID:: 3417

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000490626.

MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis

(Submitter supplied) The goals of this study are to identify differentially expressed microRNAs in muscle between JDM and normal healthy controls, and to better understand the pathophysiology of JDM.

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL17382
24 Samples

Download data: TXT

Series

Accession:: GSE49062

ID:: 200049062

Select item 2000010047.

Molecular profiles (HG-U95A) of dystrophin-deficient and normal human muscle

(Submitter supplied) Molecular profiles of dystophin-deficient patients and normal human skeletal muscles on Affymetrix HG-U95A arrays Keywords = DMD Keywords = Duchenne muscular dystrophy Keywords = dystrophin Keywords = Affymetrix U95A array Keywords = skeletal muscle Keywords = gene expression profiles Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS563
Platforms:: GPL8300 GPL91
24 Samples

Download data: CEL, EXP, RPT

Series

Accession:: GSE1004

ID:: 200001004

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 5638.

Duchenne muscular dystrophy (II) (HG-U95A)

Search for modifying factors and pathogenic pathways involved in Duchenne muscular dystrophy (DMD). Quadricep skeletal muscle biopsies from 12 DMD patients and 11 unaffected control patients examined.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL8300
Series:: GSE1004
23 Samples

Download data: CEL, EXP, RPT

DataSet

Accession:: GDS563

ID:: 563

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000017649.

Effect of Oxandrolone on Muscle in Duchenne Muscular Dystrophy

(Submitter supplied) Three subjects with Duchenne muscular dystrophy (8.3, 10.4, and 16.7 years old) were studied. Baseline studies included stable isotope infusion followed by gastrocnemius muscle biopsy to determine myosin heavy chain synthesis rates. RNA was isolated from the muscle biopsy as well. The subjects were then treated for 3 months with oxandrolone (a synthetic anabolic steroid, 0.1 mg/kg/day) and the studies repeated. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS1333 GDS1334
Platforms:: GPL97 GPL96
12 Samples

Download data

Series

Accession:: GSE1764

ID:: 200001764

Select item 133410.

Duchenne Muscular Dystrophy response to oxandrolone (HG-U133B)

Analysis of gastrocnemius muscle biopsy specimens from Duchenne muscular dystrophy (DMD) patients before and after 3 months of treatment with 0.1mg/kg/day oxandrolone, a synthetic anabolic steroid. Results provide insight into mechanisms underlying the beneficial effect of oxandrolone in DMD.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 3 individual sets

Platform:: GPL97
Series:: GSE1764
6 Samples

Download data

DataSet

Accession:: GDS1334

ID:: 1334

Select item 133311.

Duchenne Muscular Dystrophy response to oxandrolone (HG-U133A)

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 3 individual sets

Platform:: GPL96
Series:: GSE1764
6 Samples

Download data

DataSet

Accession:: GDS1333

ID:: 1333

Select item 20004828012.

Expression data from inflammatory myopathies

(Submitter supplied) MHC-I overexpression in muscle biopsies is a hallmark of inflammatory myopathies.However the mechanisms of MHC-I overexpression in each disease is not well understood. Microarray analysis from MHC-I-microdissected myofibers showed a differential expression signature in each inflammatory myopathy. Innate immunity and IFN-I pathways are upregulated vs healthy controls, specifically in dermatomyositis (DM).

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4841
Platform:: GPL6244
19 Samples

Download data: CEL

Series

Accession:: GSE48280

ID:: 200048280

Select item 484113.

Inflammatory myopathies

Analysis of pathological skeletal muscle fibers from patients with dermatomyositis (DM), polymyositis (PM), or inclusion body myositis (IBM). Results provide insight into the molecular mechanisms underlying the pathogenesis of DM, PM, and IBM.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 disease state sets

Platform:: GPL6244
Series:: GSE48280
19 Samples

Download data: CEL

DataSet

Accession:: GDS4841

ID:: 4841

Select item 20000100714.

Molecular profiles(HG-U95B,C,D,E) of dystrophin-deficient and normal human skeletal muscle

(Submitter supplied) molecular profiles (HG-U95B,C,D,E) of biopsy skeletal muscle samples obtained from 10 normal individuals and 10 DMD patients Keywords = gene expression profiles of normal human skeletal muscles Keywords = gene expression profiles of DMD patients' skelatal muscle samples Keywords = Affymetrix HG-U95B Keywords = Affymetrix HG-U95C Keywords = Affymetrix HG-U95D Keywords = Affymetrix HG-U95E Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS609 GDS610 GDS611 GDS612
4 related Platforms
86 Samples

Download data: CEL, EXP, RPT

Series

Accession:: GSE1007

ID:: 200001007

Select item 61215.

Duchenne muscular dystrophy (II) (HG-U95E)

Search for modifying factors and pathogenic pathways involved in Duchenne muscular dystrophy (DMD). Quadricep skeletal muscle biopsies from DMD patients and unaffected control patients examined.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL95
Series:: GSE1007
21 Samples

Download data: CEL, EXP, RPT

DataSet

Accession:: GDS612

ID:: 612

Select item 61116.

Duchenne muscular dystrophy (II) (HG-U95D)

Search for modifying factors and pathogenic pathways involved in Duchenne muscular dystrophy (DMD). Quadricep skeletal muscle biopsies from DMD patients and unaffected control patients examined.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL94
Series:: GSE1007
22 Samples

Download data: CEL, EXP, RPT

DataSet

Accession:: GDS611

ID:: 611

Select item 61017.

Duchenne muscular dystrophy (II) (HG-U95C)

Search for modifying factors and pathogenic pathways involved in Duchenne muscular dystrophy (DMD). Quadricep skeletal muscle biopsies from DMD patients and unaffected control patients examined.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL93
Series:: GSE1007
22 Samples

Download data: CEL, EXP, RPT

DataSet

Accession:: GDS610

ID:: 610

Select item 60918.

Duchenne muscular dystrophy (II) (HG-U95B)

Search for modifying factors and pathogenic pathways involved in Duchenne muscular dystrophy (DMD). Quadricep skeletal muscle biopsies from DMD patients and unaffected control patients examined.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL92
Series:: GSE1007
21 Samples

Download data: CEL, EXP, RPT

DataSet

Accession:: GDS609

ID:: 609

Select item 20022109119.

RNA-Seq of CD19+ B-cell, CD14+ monocyte, CD4+ and CD8+ T cell populations from patients with juvenile dermatomyositis and controls

(Submitter supplied) RNA sequencing was used to compare the transcriptional state of ex-vivo B-cells, moncytes and T-cells from children with Juvenile dermatomyositis (JDM) pre- and on-treatment and age-matched healthy controls. RNA was extracted from blood samples that were taken from juvenile dermatomyositis patients at diagnosis (before they received treatment) and approximately a year into treatment. The treatment included oral prednisolone, methotrexate, azathioprine, cyclophosphamide and other drugs.