GEO DataSets

Analysis of ME180 cervical carcinoma cells depleted for p63 isoforms by expression of a small hairpin RNA targeting the p63 oligomerization domain. p63 is a p53 homolog essential for stratified epithelial development. Results provide insight into the function of p63 in transcriptional regulation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL570

Series:

GSE5993

6 Samples

Download data: CEL

(Submitter supplied) Using tiled microarrays covering the entire human genome, we identify ~5800 target sites for p63, a homolog of the p53 tumor suppressor essential for stratified epithelial development and implicated in epithelial stem cell maintenance. Keywords: ChIP-chip

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

14 related Platforms

84 Samples

Download data: CEL

(Submitter supplied) We investigated the transcriptional effects of p63 binding by analyzing ME180 cells depleted for all p63 isoforms via expression of a small hairpin RNA (shRNA) targeting the p63 oligomerization domain. Keywords: differential expression profiling from transcription factor depletion

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2534

Platform:

GPL570

6 Samples

Download data: CEL

(Submitter supplied) Using chromatin immunoprecipitation and high-resolution tiling arrays covering the human genome, we render a genome-wide map of p73 DNA binding sites in ME180 human cervical carcinoma cells.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

7 related Platforms

7 Samples

Download data: BAR, CEL, TXT, XLS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL17021

14 Samples

Download data

(Submitter supplied) Gene expression analysis of two different mouse keratinocytes using RNA-Seq

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

4 Samples

Download data: TXT

(Submitter supplied) Mapping p63 regulatory and epigenetic landscape in mouse keratinocytes using ChIP-Seq techniques

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL17021

10 Samples

Download data: BED, BIGWIG

(Submitter supplied) Assessing the contribution of the p63 binding motif on p63-dependent enhancer activity in 5 different cellular contexts.

Organism:

Homo sapiens; synthetic construct

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL30173 GPL32628

13 Samples

Download data: CSV

(Submitter supplied) In this work, we demonstrate that the p53-induced transcriptome is dependent on pre-establishment of cell type-dependent cis-regulatory networks. The epithelial-specific p53 transcriptome is strongly dependent on p63, which acts as a pioneer factor for epithelial-specific enhancers. These results suggest a broad mechanism for regulating the p53-dependent cellular response to stress through differential regulation of cis-regulatory elements and identify p63 as a direct and critical regulator of enhancer activity in epithelial cell types.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL19057 GPL18573

98 Samples

Download data: BED, BEDGRAPH, BW, NARROWPEAK, TXT