GEO DataSets

Analysis of CD11b+ splenocytes from tumor-bearing animals. Tumor development often leads to the accumulation of CD11b+ GR-1 myeloid cells. Results provide insight into the molecular basis of the immunosuppressive activity exhibited by tumor-induced CD11b+ splenocytes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 growth protocol sets

Platform:

GPL81

Series:

GSE5455

9 Samples

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(Submitter supplied) Active suppression of tumor-specific T lymphocytes can limit the immune-surveillance and immunotherapy efficacy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their immunosuppressive activity remain elusive. Here we describe a population of circulating CD11b+/IL-4Rα+, inflammatory-type monocytes that is elicited by growing tumors and activated by IFN-γ released from T lymphocytes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2454

Platform:

GPL81

9 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10361

21 Samples

Download data: TXT

(Submitter supplied) Chronic inflammation is known to associate with prostate cancer development, but how epithelium-associated cancer initiating events cross-talk to inflammatory cells during prostate cancer initiation and progression is largely unknown. Using the Pten null murine prostate cancer model, we show an expansion of Gr-1+CD11b+ myeloid-derived suppressor cells (MDSCs) occurring intra-prostatically immediately following epithelium-specific Pten deletion without expansion in hematopoietic tissues. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10361

6 Samples

Download data: TXT

(Submitter supplied) Chronic inflammation is known to associate with prostate cancer development, but how epithelium-associated cancer initiating events cross-talk to inflammatory cells during prostate cancer initiation and progression is largely unknown. Using the Pten null murine prostate cancer model, we show an expansion of Gr-1+CD11b+ myeloid-derived suppressor cells (MDSCs) occurring intra-prostatically immediately following epithelium-specific Pten deletion without expansion in hematopoietic tissues. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10361

15 Samples

Download data: TXT

(Submitter supplied) Comparison of gene expression identified several significantly overexpressed genes in tumors recovered from hetIL-15-treated mice. These upregulated genes after hetIL-15 treatment represent an expression signature that corresponds to activated TILs with cytotoxic phenotype. Nanostring analysis also identified additional functional pathway signatures, including signal transducer and activator of transcription (STAT) intracellular signaling, TCR recognition of cognate antigen, interferons signaling, increased metabolic rate and immune cell chemotaxis

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL28519

11 Samples

Download data: RCC, XLSX

(Submitter supplied) We report differential gene expression in inflammatory monocyte (IM), tumor-associated macrophage (TAM), and CD8 T cell populations following stereotactic body radiation (SBRT), intratumoral interleukin 12 microsphere (IL-12 MS) delivery, and SBRT/IL-12 MS combination. Immune cell populations were sorted from orthotopic murine pancreatic ductal adenocarcinoma (PDA) tumors prior to RNA sequencing.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

33 Samples

Download data: TXT

(Submitter supplied) The immunosuppressive microenvironment surrounding tumor cells represents a key cause of treatment failure. Therefore, immunotherapies aimed at reprogramming the immune system have largely spread in the past years. We employed gene transfer into hematopoietic stem and progenitor cells to selectively express anti-tumoral cytokines in tumor-infiltrating monocytes/macrophages. We show that Interferon-γ (IFNγ) reduced tumor progression in mouse models of B-cell acute lymphoblastic leukemia (B-ALL) and colorectal carcinoma (MC38). more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL24247

11 Samples

Download data: CSV, MTX, TSV

(Submitter supplied) We characterized tumor-associated macrophages and found a pro-inflammatory signature of those cells in picrotoxin-treated mice compared to those in control mice (DMSO).

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16417

12 Samples

Download data: TXT

(Submitter supplied) We characterized the tumor-infiltrating macrophages and CD8 T cells, and we found a pro-inflammatory signature of those cells in muMt-/- mice compared to those in WT mice. Furthermore, many target genes of inflammatory cytokines, such as the TNF target genes, highly expressed in muMt-/- mice, were downregulated by exogenous of GABA.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16417

36 Samples

Download data: TXT

(Submitter supplied) C57BL/6 mice were injected orthotopically with M3-9-M ffluc-mCherry rhabdomyosarcoma tumor cells in the gastrocnemius muscle of the leg. Mice were treated with 8E6 IL12-secreting genetically engineered myeloid cells (IL12-GEMys) on day 12 post tumor inoculation. Lungs were harvested 3 days post IL12-GEMy treatment, 15 days post primary tumor inoculation. 3' single cell RNA-Seq was performed on isolated cells.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

14 Samples

Download data: H5

(Submitter supplied) The objective of this study was to profile the transcriptional landscape in the pre-metastatic lungs of mice with and without IL12-GEMy treatment.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

17 Samples

Download data: TXT

(Submitter supplied) We used Single-cell RNA-sequencing to analyze the composition of the tumor microenvironment of MC38mOVA tumors upon transcutaneous immunization with our immunization method DIVA.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

2 Samples

Download data: CSV