GEO DataSets

Analysis of 33 biopsies from 11 cervical cancer patients. Biopsies were obtained from 2 to 5 different areas of each tumor. Results provide insight into the extent of intratumor heterogeneity in gene expression in cervical cancer patients.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 11 individual sets

Platform:

GPL570

Series:

GSE5787

33 Samples

Download data: CEL, EXP

(Submitter supplied) Purpose: To explore intratumor heterogeneity in gene expression profiles from patients with cervical cancer. Experimental Design: A total of 33 biopsies were obtained from 11 patients, sampling between two and five different areas for each tumor.The extracted RNAwas hybridized onto the Affymetrix U133 Plus 2.0 oligonucleotide chip. The variance of expression within a patient (W), between patients (B) and the total variance (T =W + B) were calculated for each ProbeSet, and the ratio W/T was used as a measure of intratumor heterogeneity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2416

Platform:

GPL570

33 Samples

Download data: CEL, EXP

(Submitter supplied) In cervical cancer, an important mechanism by which tumour cells escape immune surveillance is loss of HLA class I, enabling tumours to evade recognition and lysis by cytotoxic T lymphocytes. Some tumours, however, escape from immune surveillance without accumulating defects in antigen presentation. We hypothesized that tumours with no or partial loss of HLA class I develop alternative mechanisms to prevent immune surveillance. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

36 Samples

Download data: TXT

(Submitter supplied) The microarray slide has the dimensions of a regular microscopy slide. Its grid/sub-grid structure is in the uploaded raw data file. Protocol: Takara's microarrays contain denatured double stranded cDNAs arrayed on glass slides. Spot size of the present platform is 150um with space between spots 300um. The grid structure of this platform is 2 x 2 (2 meta-rows x 2 meta-columns). Each subgrid has a structure of 16x18 (16 rows x 18 columns). more...

Organism:

Homo sapiens

2 Series

18 Samples

Download data

(Submitter supplied) Laryngeal squamous cell carcinoma is a very common in head and neck cancer, accounting for 25% of all cases, with high mortality rates and poor prognosis. In this study, we compared expression profiles of clinical samples from15 larynx tumors and 10 non-neoplastic larynx tissue using a custom-built cDNA microarray containing 332 probes for 285 genes previously identified as up- or down-regulated in head and neck tumors by the Head and Neck Annotation Consortium (Reis et al., Cancer Res 65:1693-99, 2005). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6426

46 Samples

Download data: TXT

(Submitter supplied) Tumor tissue heterogeneity is a well known feature of several solid tumors. Neuroblastic Tumors (NTs) is a group of paediatric cancers with a great tissue heterogeneity. Most of NTs are composed of undifferentiated, poorly differentiated or differentiating neuroblastic (Nb) cells with very few or absent Schwannian stromal (SS) cells: these tumors are grouped as Neuroblastoma (Schwannian stroma-poor). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

28 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling of early stage cervical cancer tumours with and without lymph node metastasis, in order to predict lymph node metastasis before treatment. Subsequently, comparing gene expression profiles between healthy cervical tissue and early stage cervical cancer tissue. Keywords: Disease stage analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1708

45 Samples

Download data: TXT

(Submitter supplied) Acute lymphoblastic leukemia (ALL) is an heterogeneous disease comprising several subentities that differ for both immunophenotypic and molecular characteristics. Over the years, the biologic understanding of this neoplasm has largely increased. Gene expression profiling has recently allowed to identify specific signatures for the different ALL subsets and permitted identification of pathways deregulated by a given lesion. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL570 GPL8191

39 Samples

Download data: CEL, XLS

(Submitter supplied) A better understanding of the consequences of recurrent (epi)genetic alterations that occur during cervical carcinogenesis is essential in the search for novel biomarkers. In this study we determined genome-wide expression profiles of 10 squamous cell carcinomas (SCCs), 5 adenocarcinomas (AdCAs) and 6 normal epithelial samples. Expression patterns were subsequently combined with previously determined chromosomal profiles in the same carcinomas. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array; Expression profiling by genome tiling array

Platforms:

GPL3054 GPL3441

38 Samples

Download data

(Submitter supplied) Although gain of chromosome-5p is one of the most frequent DNA copy number imbalances in cervical squamous cell carcinoma (SCC), the genes that drive its selection remain poorly understood. In a previous cross-sectional clinical study we showed that the microRNA processor Drosha (located on chromosome-5p) demonstrates frequent copy-number gain and over-expression in cervical SCC, associated with altered microRNA profiles. more...

Organism:

JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Betapolyomavirus macacae; Homo sapiens; Human betaherpesvirus 5; Rhadinovirus; Betapolyomavirus hominis; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Lymphocryptovirus

Type:

Non-coding RNA profiling by array; Expression profiling by array

Platforms:

GPL11338 GPL570

24 Samples

Download data: CEL, TXT

(Submitter supplied) Comparison of mRNA expression profiles in W12 Series 1 cervical ectokeratinocytes at passage number 22 versus 19 (during which time the cells gain an invasive phenotype) As these cells demonstrate gain of chromosome 5p during this time, mRNA expression profiling data interrogated for over-expressed genes on 5p that may be important in cervical neoplastic progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data: CEL

(Submitter supplied) Comparison of miRNA expression profiles in cervical carcinoma cell lines to study the effects of Drosha expression levels

Organism:

Human alphaherpesvirus 2; Lymphocryptovirus; Merkel cell polyomavirus; JC polyomavirus; Betapolyomavirus macacae; Homo sapiens; Rhadinovirus; Betapolyomavirus hominis; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1

Type:

Non-coding RNA profiling by array

Platform:

GPL11338

18 Samples

Download data: TXT

(Submitter supplied) Studying the causes and correlates of natural variation in gene expression in healthy populations assumes that individual differences in gene expression can be reliably and stably assessed across time. However, this is yet to be established. We examined 4-hour test-retest reliability and 10 month test-retest stability of individual differences in gene expression in 10 12-year-old children.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

36 Samples

Download data: CEL