GEO DataSets

Analysis of infarcted left heart ventricle of Spraque-Dawley males following treatment with thyroid hormone analog 3,5-diiodothyropropionic acid (DITPA), or captopril followed by DITPA. Results provide insight into the effect of these drugs in congestive heart failure.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log2 ratio, 3 agent, 2 disease state sets

Platform:

GPL3801

Series:

GSE4963

20 Samples

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(Submitter supplied) Three weeks after infarction, age matched rats with large infarction by ECG criteria were randomly assigned to one of the three groups: 1) Treatment with Captopril for 21 days and a daily subcutaneous dose of DITPA for the last 10 days of treatment, 2) Treatment for 10 days with DITPA alone, 3) Control heart failure and 4) Sham-operated. Keywords: Drug Effects on Heart Failure

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2174

Platform:

GPL3801

20 Samples

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(Submitter supplied) Rat ventricular cardiomyocytes were prepared from 18 day old fetus. Approximately 6 million cells were plated on 100 mm culture plate. The serum used in the medium was depleted from thyroid hormone by passing through anion exchange resin column. After 48 hours of growth with 70% confluency, cells were exposed to either T3, DITPA or CGS for another 48 hours before harvesting. Final concentrations of T3, DITPA and CGS in the medium were 6nM, 218nM and 1nM respectively. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS468 GDS469

Platform:

GPL333

10 Samples

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Analysis of effect of 48 hours exposure to thyroid hormone triiodothyronine (T3) and structural analogues DITPA and CGS on primary culture cardiomyocytes prepared from 18 day old fetus. Thyroid hormone may be useful in treatment of heart failure.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL333

Series:

GSE602

3 Samples

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Analysis of effect of 48 hours exposure to thyroid hormone triiodothyronine (T3) and structural analogues DITPA and CGS on primary culture cardiomyocytes prepared from 18 day old fetus. Thyroid hormone may be useful in treatment of heart failure.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL333

Series:

GSE602

3 Samples

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(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Time and dose related expression profiles of rat right heart tissue in microsphere bead model for Pulmonary embolism Keywords: Time course and dose response in experimental PE

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3414

Platform:

GPL1355

45 Samples

Download data: CEL

Analysis of right ventricles (RV) of animals for up to 18 hours after injection with polystyrene microsphere beads to induce pulmonary embolism (PE). Animals injected with 1.3 or 2.0 million microspheres/100g body weight. Results provide insight into the mechanisms leading to RV failure after PE.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 3 dose, 3 time sets

Platform:

GPL1355

Series:

GSE6104

45 Samples

Download data: CEL