Similar studies for GEO DataSets (Select 2138) - GEO DataSets

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Items: 2

Select item 21381.

Breast cancer cells resistant to green tea polyphenol epigallocatechin 3-gallate growth inhibition

Analysis of NF639 breast cancer cells resistant to growth inhibition by green tea polyphenol epigallocatechin 3-gallate (EGCG) after initial EGCG sensitivity. EGCG inhibits growth of NF639 cells by inhibiting Her-2/Neu signaling. Results provide insight into mechanisms underlying EGCG resistance.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 isolate sets

Platform:: GPL339
Series:: GSE4140
4 Samples

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Accession:: GDS2138

ID:: 2138

Select item 2000041402.

NF639 cells original population vs EGCG-resistant population

(Submitter supplied) Overexpression of the epidermal growth factor receptor family member Her-2/neu in breast cancer leads to autophosphorylation of the receptor, and induction of multiple downstream signaling pathways including Akt kinase to NF-kappaB cascade that is associated with poor prognosis. Previously, we demonstrated green tea polyhenol epigallocatechin 3-gallate (EGCG) inhibits growth of NF639 Her-2/neu-driven breast cancer cells via reducing receptor autophosphorylation, and downstream Akt and NF-kappaB activities (Pianetti et al., 2002). more...