Similar studies for GEO DataSets (Select 200242381) - GEO DataSets

Select item 2002423811.

Hypothalamic thyroid hormone deficiency underlies reversible anorexia in a mammalian hibernator

(Submitter supplied) Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels lasts for 5–7 months and comprises weeks of hypometabolic, hypothermic torpor interspersed with 24–48-hour periods of an active-like interbout arousal (IBA) state. more...

Organism:: Ictidomys tridecemlineatus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30340
6 Samples

Download data: TAR

Series

Accession:: GSE242381

ID:: 200242381

PubMed Full text in PMC Similar studies

Select item 2002314182.

Neural control of fluid homeostasis is engaged below 10°C in hibernation

(Submitter supplied) Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) hibernate for several months each winter without access to water, but the mechanisms that maintain fluid homeostasis during hibernation are poorly understood. In torpor, when body temperature (TB) reaches 4°C, squirrels decrease metabolism, slow heart rate, and reduce plasma levels of the antidiuretic hormones arginine vasopressin (AVP) and oxytocin (OXT). more...

Organism:: Ictidomys tridecemlineatus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30340
15 Samples

Download data: XLSX

Series

Accession:: GSE231418

ID:: 200231418

PubMed Similar studies

Select item 2001363963.

RNASeq of cold-sensitive and cold-insensitive neurons from the pre-optic area of hypothalamus of mice

(Submitter supplied) The preoptic area of the hypothalamus (POA) contains intrinsically warm and cold-sensitive neurons, which are thought to be critically involved in mammalian thermoregulation. However, the precise physiological roles and the molecular markers of the cold-sensitive POA neurons have not been determined yet. Here, we tackle this problem by performing calcium-imaging guided separation and collection of cold-sensitive and cold-insensitive dissociated neurons from the mouse POA, followed by RNASeq and differential transcriptomics of these cell populations.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: XLSX

Series

Accession:: GSE136396

ID:: 200136396

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002072114.

Activation of immediate early response genes initiates a restorative gene expression program during each arousal from torpor in hibernating 13-lined ground squirrels

(Submitter supplied) RNA-seq libraries were prepared from replicate samples (n=5-6) from six physiolocial groups to capture key changes in circannual hibernation.

Organism:: Ictidomys tridecemlineatus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24271 GPL30340
31 Samples

Download data: TSV

Series

Accession:: GSE207211

ID:: 200207211

PubMed Similar studies

Select item 2001668145.

Liver transcriptome dynamics during hibernation are shaped by a shifting balance between transcription and RNA stability

(Submitter supplied) Hibernators dramatically lower metabolism to save energy while fasting for months. Prolonged fasting challenges metabolic homeostasis, yet small-bodied hibernators emerge each spring ready to resume all aspects of active life, including immediate reproduction. The liver is the body’s metabolic hub, processing and detoxifying macromolecules to provide essential fuels to brain, muscle and other organs throughout the body. more...