Similar studies for GEO DataSets (Select 200231343) - GEO DataSets

Select item 2002313431.

Predicting gene level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework I

(Submitter supplied) To link upstream IL-6 and IL-10-induced JAK-STAT signaling to downstream gene expression in bone marrow derived macrophages (BMDMs). Bulk RNAseq was done on cytokine-stimulated BMDM in order to profile cytokine-induced response.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
40 Samples

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Series

Accession:: GSE231343

ID:: 200231343

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Select item 2002313452.

Predicting gene level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
60 Samples

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Series

Accession:: GSE231345

ID:: 200231345

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Select item 2002313443.

Predicting gene level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework II

(Submitter supplied) To inhibit JAK2 upon IL-6 and IL-10-induced JAK-STAT signaling and quantify gene expression in bone marrow derived macrophages (BMDMs). Bulk RNAseq was done on cytokine-stimulated BMDM with and without Fedratinib treatment in order to profile the JAK2-inhibited cytokine-induced response.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
20 Samples

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Series

Accession:: GSE231344

ID:: 200231344

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Select item 2002206544.

MOUSE peritoneal macrophages treated with C498 or LPS

(Submitter supplied) Mouse peritoneal macrophages were isolated and treated with vehicle or C498 (15 μM) for 0.5 h, followed by LPS (100 ng/ml) challenge for an additional 4 h.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

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Series

Accession:: GSE220654

ID:: 200220654

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Select item 2001644795.

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders

(Submitter supplied) High levels of inflammation are often present in autoimmune diseases and can impact the functioning of the immune system. Specifically, how surrounding inflammation affects cytokine responses has not been extensively studied. We use IL-6 and IL-27, two cytokines playing opposite roles in inflammation, to ask how cytokines adapt to the inflammatory environment. We show that IL-27 induces a more sustained STAT1 phosphorylation than IL-6, with the two cytokines inducing comparable levels of STAT3 phosphorylation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
21 Samples

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Series

Accession:: GSE164479

ID:: 200164479

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