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Links from GEO DataSets

Items: 20

1.

Real-time quantitative PCR analysis of gene expression in mouse macrophages treated with bacterial endotoxin lipopolysaccharide

(Submitter supplied) Relative mRNA levels of 27 genes were evaluated with the SYBR Green qPCR assays after LPS treatment for 2-24 h.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL32257
72 Samples
Download data: XLSX
Series
Accession:
GSE204820
ID:
200204820
2.

Real-time quantitative PCR analysis of gene expression in human colon cancer cells treated with cottonseed-derived gossypol

(Submitter supplied) Relative mRNA levels of 55 genes were evaluated with the SYBR Green qPCR assays after gossypol treatment for 8 h.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL32173
24 Samples
Download data: XLSX
Series
Accession:
GSE204818
ID:
200204818
3.

Real-time quantitative PCR analysis of gene expression in mouse macrophages treated with cottonseed-derived gossypol

(Submitter supplied) Relative mRNA levels of 27 genes were evaluated with the SYBR Green qPCR assays after gossypol (Gos) treatment for 2-24 h.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL32257
72 Samples
Download data: TXT
Series
Accession:
GSE203027
ID:
200203027
4.

Real-time quantitative PCR analysis of gene expression in human colon cancer cells treated with LPS

(Submitter supplied) Relative mRNA levels of 55 genes were evaluated with the SYBR Green qPCR assays after LPS treatment for 8 h.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL32173
12 Samples
Download data: TXT
Series
Accession:
GSE200980
ID:
200200980
5.

DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes

(Submitter supplied) Murine embryonic fibroblasts were isolated from WT and DGAT1,DGAT2-KO (D1D2KO) animals. mRNA was isolated from cells untreated (UNDIFF) or treated (DIFF) according to standard differentiation protocol for adipocytes (Harris, C, et al. JLR 2011).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE26624
ID:
200026624
6.

Tristetraprolin specifically regulates the expression and alternative splicing of immune response genes in Hela cells

(Submitter supplied) we cloned and overexpressed human TTP-encoding gene ZFP36 in HeLa cell in the absence of inflammatory stimuli. The transcriptomes of the control and ZFP36-overexpression cells were sequenced and subjected to analysis and validation. Upon ZFP36 overexpression, expression of genes in innate immunity, including those in type I interferon signaling pathway and viral response, were specifically up-regulated, implying a transcriptional regulatory mechanism associated with the predicted DNA binding activity of TTP. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20795
4 Samples
Download data: TXT
7.

TTP-dependent mRNA decay in LPS-stimulated macrophages

(Submitter supplied) Controlled decay of cytokine and chemokine mRNAs restrains the time and amplitude of inflammatory responses. Tristetraprolin (TTP) binds to AU-rich elements in 3ยด untranslated regions of mRNA and targets the bound mRNA for degradation. We have addressed here the function of TTP in balancing the macrophage activation state by a comprehensive analysis of TTP-dependent mRNA decay in LPS-stimulated macrophages from WT and TTP-deficient mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
18 Samples
Download data: CEL
Series
Accession:
GSE28880
ID:
200028880
8.

Pervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [RNA-Seq_2]

(Submitter supplied) Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high resolution occupancy assessment of the mRNA-destabilizing protein TTP, a major inflammation-limiting factor, we qualitatively and quantitatively characterize TTP binding positions and functionally relate them to TTP-dependent mRNA decay in immunostimulated macrophages. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL17021
42 Samples
Download data: XLS
Series
Accession:
GSE78209
ID:
200078209
9.

TTP binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL13112 GPL17021
49 Samples
Download data
Series
Accession:
GSE63468
ID:
200063468
10.

Pervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [RNA-Seq]

(Submitter supplied) Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high resolution occupancy assessment of the mRNA-destabilizing protein TTP, a major inflammation-limiting factor, we qualitatively and quantitatively characterize TTP binding positions and functionally relate them to TTP-dependent mRNA decay in immunostimulated macrophages. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data: TXT
Series
Accession:
GSE63467
ID:
200063467
11.

Pervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [PAR-iCLIP]

(Submitter supplied) Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high resolution occupancy assessment of the mRNA-destabilizing protein TTP, a major inflammation-limiting factor, we qualitatively and quantitatively characterize TTP binding positions and functionally relate them to TTP-dependent mRNA decay in immunostimulated macrophages. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
5 Samples
Download data: TXT
Series
Accession:
GSE63466
ID:
200063466
12.

Synergistic roles of tristetraprolin family members in myeloid cells in controlling inflammation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
128 Samples
Download data: BW
Series
Accession:
GSE229924
ID:
200229924
13.

Differential Gene Expression and mRNA decay in Wild-Type and Myeloid-specific TTP Family Member Triple (M-Triple) Knock-out macrophages using RNA-Seq

(Submitter supplied) Members of the tristetraprolin (TTP) family of RNA-binding proteins can bind to and promote the decay of specific transcripts containing AU-rich motifs. ZFP36 (TTP) is best known for regulating cytokine expression in myeloid cells; however, the mammalian paralogues ZFP36L1 and ZFP36L2 have not been viewed as important in controlling inflammation. To study potential functional overlaps of these three TTP family proteins in myeloid cells, we developed myeloid-specific knock-out (M-KO) mice of these genes, singly and together. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
64 Samples
Download data: BW, GTF, TXT
Series
Accession:
GSE229923
ID:
200229923
14.

Differential Gene Expression and mRNA decay in Wild-Type and Myeloid-specific TTP Knock-out macrophages using RNA-Seq

(Submitter supplied) Members of the tristetraprolin (TTP) family of RNA-binding proteins can bind to and promote the decay of specific transcripts containing AU-rich motifs. ZFP36 (TTP) is best known for regulating cytokine expression in myeloid cells; however, the mammalian paralogues ZFP36L1 and ZFP36L2 have not been viewed as important in controlling inflammation. To study potential functional overlaps of these three TTP family proteins in myeloid cells, we developed myeloid-specific knock-out (M-KO) mice of these genes, singly and together. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
64 Samples
Download data: BW, GTF, TXT
Series
Accession:
GSE229922
ID:
200229922
15.

Single-cell transcriptomic analysis reveals the developmental trajectory and transcriptional regulatory networks of pigment glands in Gossypium bickii

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Gossypium bickii
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL33097 GPL33091
19 Samples
Download data: MTX, TSV
Series
Accession:
GSE224635
ID:
200224635
16.

Single-cell transcriptomic analysis reveals the developmental trajectory and transcriptional regulatory networks of pigment glands in Gossypium bickii [scRNA-seq]

(Submitter supplied) Comprehensive utilization of cottonseeds is limited by the presence of pigment gland and its inclusion gossypol. The ideal cotton is glandless-seeds and glanded-plant, a trait found in only few Australian wild cotton species, including Gossypium bickii. Introgressing the trait to cultivated species is proved to be difficult. Understanding the biological processes towards pigment gland morphogenesis and the associated underlying molecular mechanisms will facilitate breeding cultivated cotton varieties with the trait of glandless-seeds and glanded-plant. more...
Organism:
Gossypium bickii
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33097
1 Sample
Download data: MTX, TSV
Series
Accession:
GSE224633
ID:
200224633
17.

Single-cell transcriptomic analysis reveals the developmental trajectory and transcriptional regulatory networks of pigment glands in Gossypium bickii [bulk RNA-seq]

(Submitter supplied) Comprehensive utilization of cottonseeds is limited by the presence of pigment gland and its inclusion gossypol. The ideal cotton is glandless-seeds and glanded-plant, a trait found in only few Australian wild cotton species, including Gossypium bickii. Introgressing the trait to cultivated species is proved to be difficult. Understanding the biological processes towards pigment gland morphogenesis and the associated underlying molecular mechanisms will facilitate breeding cultivated cotton varieties with the trait of glandless-seeds and glanded-plant. more...
Organism:
Gossypium bickii
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33091
18 Samples
Download data: TXT
Series
Accession:
GSE224574
ID:
200224574
18.

The ZFP36 family of RNA-binding proteins regulates homeostatic and autoreactive T cell responses

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
56 Samples
Download data
Series
Accession:
GSE192956
ID:
200192956
19.

The ZFP36 family of RNA-binding proteins regulates homeostatic and autoreactive T cell responses [mRNA-decaySeq]

(Submitter supplied) These are CD44hi CD4 T splenic T cells from the indicated mice activated in vitro with anti-CD3/anti-CD28 for 24 hours. Following activation, cells were treated with Actinomycin D for the indicated time course.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
24 Samples
Download data: TXT
Series
Accession:
GSE192954
ID:
200192954
20.

The ZFP36 family of RNA-binding proteins regulates homeostatic and autoreactive T cell responses [RNA-Seq]

(Submitter supplied) These are spleen and kidney T cells directly analyzed from the indicated mice by RNA-seq.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
32 Samples
Download data: TXT
Series
Accession:
GSE192953
ID:
200192953

Supplemental Content

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