Similar studies for GEO DataSets (Select 200178519) - GEO DataSets

(Submitter supplied) Human fetal lung tip cells were purifed from developing human lungs at pseudoglandular and canalicular stages and in vitro cultured; pseudoglandular organoids and LinPOS organoids, respectively. Alveolar organoids were differentiated from LinPOS organoids in the alveolar differentiation condition. Differential NKX2.1 binding patterns in each organoid were profiled by targeted DamID-seq.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
18 Samples

Download data: BED, BW

Series

Accession:: GSE189155

ID:: 200189155

PubMed Similar studies SRA Run Selector

Select item 2001785296.

Acquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL20301
28 Samples

Download data: BW

Series

Accession:: GSE178529

ID:: 200178529

PubMed Similar studies

Select item 2001785287.

Transcriptomic data from cultured human fetal lung tip-derived organoids at different stages of lung development

(Submitter supplied) Human fetal lung tip cells were purifed from developing human lungs at pseudoglandular and canalicular stages and in vitro cultured as organoids. Whole transcriptomic data for each organoid line at different stages were profiled by RNA seq.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
6 Samples

Download data: CSV

Series

Accession:: GSE178528

ID:: 200178528

PubMed Similar studies SRA Run Selector

Select item 2001785278.

Genome-wide chromatin accessibility data from cultured human fetal lung tip-derived organoids at different stages of lung development

(Submitter supplied) Human fetal lung tip cells were purifed from developing human lungs at pseudoglandular and canalicular stages and in vitro cultured as organoids. Chromatin accessibility data for each organoid line at different stages were profiled by ATAC-seq.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
4 Samples

Download data: BED, BW

Series

Accession:: GSE178527

ID:: 200178527

PubMed Similar studies SRA Run Selector

Select item 2001681919.

The human respiratory airways contain a distinct multipotent secretory cell lineage that can regenerate lung alveoli

(Submitter supplied) The human lung differs substantially from its murine counterpart, resulting in a distinct distal airway architecture affected by disease pathology in chronic obstructive pulmonary disease. In humans, the distal branches of the airway interweave with the alveolar gas exchange niche, forming an anatomical structure known as the respiratory airways. Due to the lack of a murine counterpart, the cellular and molecular characterization of the respiratory airways in the human lung remains an enigma. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
19 Samples

Download data: H5

Series

Accession:: GSE168191

ID:: 200168191

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013007610.

Single cell transcriptome analysis of distal adult human lung airway cells

(Submitter supplied) To comprehensively study the heterogeneity within distal airway epithelium, we performed single cell transcriptomic analysis of the normal human donor lung samples. Our analysis reveals that secretory (club) and basal cells in the distal lung airway epithelial cells are highly heterogenous. Further interrogation of secretory cells identified a subpopulation with potential for alveolar differentiation in vitro, implicating distal lung airway secretory cells as new candidates in alveolar repair and regeneration.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE130076

ID:: 200130076

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014163511.

Histone modifications in lung epithelial cells

(Submitter supplied) We report histone modifications in alveolar epithelial type 2 cells in homeostatic mice as well as CTGF-positive alveolar eptihelial cells in mice treated with Bleomycin.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21273 GPL24247
20 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE141635

ID:: 200141635

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014163412.

single-cell RNA-seq in alveolar organoids cultured in MTECplus medium

(Submitter supplied) We performed Drop-seq using alveolar organoids cultured in MTECplus medium to identify cell types, gene expression patterns and signaling pathways in ex vivo condition.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
1 Sample

Download data: TSV

Series

Accession:: GSE141634

ID:: 200141634

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005258313.

High throughput quantitative whole transcriptome analysis of distal mouse lung epithelial cells from various developmental stages (E14.5, E16.5, E18.5 and adult)

(Submitter supplied) We used microfluidic single cell RNA-seq on 198 individual mouse lung epithelial cells at 4 different stages throughout development to measure the transcriptional states which define the developmental and cellular hierarchy of the distal mouse lung epithelium. We classified 80 cells comprising the distal lung epithelium at E18.5 into distinct populations using an unbiased genome-wide approach that did not require a priori knowledge of the underlying cell types or prior purification of cell types. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL16417
201 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE52583

ID:: 200052583

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20019056514.

Single cell transcriptional profiling of native, transplanted, or organoid SCA1+ and SCA1- lung epithelial cells

(Submitter supplied) The study examined the ability of SCA1+ and SCA1- lung epithelial organoids to be transplanted and retained by donor mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
15 Samples

Download data: MTX, TSV

Series

Accession:: GSE190565

ID:: 200190565

PubMed Full text in PMC Similar studies

Select item 20009705515.

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL16791
16 Samples

Download data: CSV, NARROWPEAK

Series

Accession:: GSE97055

ID:: 200097055

PubMed Full text in PMC Similar studies

Select item 20009705416.

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor [mouse RNA-seq]

(Submitter supplied) The lung alveolus is the primary site of gas exchange in mammals. Within the alveolus, the alveolar type 2 (AT2) epithelial cell population generates surfactant to maintain alveolar structure and harbors a regenerative capacity to repair the alveolus after injury. We show that a Wnt-responsive alveolar epithelial progenitor (AEP) lineage within the AT2 cell population is critical for regenerating the alveolar niche. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
5 Samples

Download data: CSV

Series

Accession:: GSE97054

ID:: 200097054

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009705317.

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor [human RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
9 Samples

Download data: CSV

Series

Accession:: GSE97053

ID:: 200097053

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009705218.

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor [ATAC-seq]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: NARROWPEAK

Series

Accession:: GSE97052

ID:: 200097052

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014125919.

Longitudinal single-cell transcriptomics analysis of mouse lung upon bleomycin-induced injury

(Submitter supplied) Two single-cell RNA sequencing data sets were generated called "Whole lung" and "High Resolution". The "Whole lung" single-cell mRNAseq libraries were generated with Drop-Seq from whole mouse lungs upon bleomycin-induced injury and followed over time. Samples were taken at days 3 (n = 3), 7 (n = 5), 10 (n = 3), 14 (n = 4), 21 (n = 4) and 28 (n = 2). Control samples (n = 7) were administered saline only, also indicated with PBS or day0. more...