Similar studies for GEO DataSets (Select 200174728) - GEO DataSets

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Items: 3

Select item 2001747281.

Single cell RNA sequencing of femur bone marrow cells from the NZBWF1 systemic lupus erythematosus mouse model and its progenitors.

(Submitter supplied) Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by failure of self-tolerance mechanisms and the resultant production of autoreactive antibodies. The NZBWF1 mouse spontaneously develops a lupus-like syndrome and is used as model of SLE. The NZBWF1 model represents the F1 generation of a cross between New Zealand Black (NZB) and New Zealand White (NZW) mice. In this study we investigated the model and its progenitors (NZB, NZW) gene expression with single cell RNA sequencing on cells isolated from bone marrow and processed with the 10X Chromium.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
9 Samples

Download data: CSV, H5, MTX, TSV

Series

Accession:: GSE174728

ID:: 200174728

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000974392.

Transcriptomic data for splenic neutrophils isolated from female NZBWF1/J lupus mice

(Submitter supplied) Recent literature has shown that neutrophils exert significant influence on the course of disease progression in lupus, but there is currently controversy in the lupus field regarding a) whether neutrophils are predominantly protective or deleterious toward the propagation of auto-reactivity, b) the specific mechanism of neutrophil influence on adaptive immune dysregulation, and c) identity and origin of functionally abnormal neutrophil subsets in lupus. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
18 Samples

Download data: TXT

Series

Accession:: GSE97439

ID:: 200097439

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002375403.

Gene expression analysis of FO B and ABCs of young and aged mice.

(Submitter supplied) We report the global gene expression in follicular (FO) B cells and age/autoimmunity-associated B cells (ABCs). We found that Fc-receptor like (Fcrl) 5 was highly expressed in ABCs isolated from 50-week-old mice, compared to FO B cells. This study provides a basis for understanding the relationship between autoimmune diseases and Fcrl5 expression in B cells.