Similar studies for GEO DataSets (Select 200156054) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2001560541.

Next Generation Sequencing of EGFR-mutant non-small cell lung cancer (NSCLC) cells with tyrosine kinase inhibitor (TKI)-resistance

(Submitter supplied) Purpose: The aim of this study is to compare the differentially expressed transcriptome of TKI resistance NSCLC cells and their parental cells Methods: mRNA profiles of the TKI-resistant NSCLC cells and their parental cells were generated by deep sequencing using Illumina HiSeq4000. Clean RNA-seq data was quantified and analyzed using the CLC genomics workbench software version 11.0 (Qiagen, Hilden, Germany). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
6 Samples

Download data: TXT

Series

Accession:: GSE156054

ID:: 200156054

Select item 2000666042.

Inhibition of ABCB1 Overcomes Cancer Stem Cell-like Properties and Acquired Resistance to MET inhibitor in Non-Small Cell Lung Cancer

(Submitter supplied) Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations have shown a dramatic response to EGFR inhibitors (EGFR-TKI). EGFR T790M mutation and MET amplification have been recognized as major mechanisms of acquired resistance to EGFR-TKI. Therefore, MET inhibitors have recently been used in NSCLC patients in clinical trials. In this study, we tried to identify the mechanism of acquired resistance to MET inhibitor. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
2 Samples

Download data: CEL

Series

Accession:: GSE66604

ID:: 200066604

Select item 2002475843.

Molecular mechanisms of BCAT1 in ASK120067-resistant NSCLC cells

(Submitter supplied) To investigate the mechanism of BCAT1 in mediating resistance to third-generation EGFR-TKI, we employed RNA-seq analysis to compare the transcriptome signature of ASK120067-resistant NSCLC cells with or without BCAT1 knockdown. Here, gene set enrichment (GSEA) revealed a significant decrease in the expression of genes in glycolysis pathway following small interfering RNA (siRNA)-mediated BCAT1 knockdown, which indicated the role for BCAT1 in supporting TKI resistance through upregulation of glycolysis.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: TXT

Series

Accession:: GSE247584

ID:: 200247584

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001108154.

miRNA expression of gefitinib-resistant cell lines

(Submitter supplied) To identify novel miRNAs involved in acquired EGFR TKI resistance in NSCLC, genome-wide miRNA expression analysis was performed in gefitinib-resistant sub-cell lines and gefitinib-sensitive parental cell lines.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL18402
4 Samples

Download data: TXT, XLSX

Series

Accession:: GSE110815

ID:: 200110815

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000518285.

miR-134/487b/655 Cluster regulates TGF-β-induced epithelial-mesenchymal transition and drug resistance to Gefitinib by targeting MAGI2 in lung adenocarcinoma cells.

(Submitter supplied) Epithelial-mesenchymal transition (EMT) has recently been recognized as a key element of cell invasion, migration, metastasis, and drug resistance in several types of cancer, including non-small cell lung cancer (NSCLC). Our aim was to clarify microRNA (miRNA) -related mechanisms underlying EMT followed by acquired resistance to epidermal growth factor receptor tyrosine-kinase inhibitor (EGFR-TKI) in NSCLC. more...

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL17853
8 Samples

Download data: TXT

Series

Accession:: GSE51828

ID:: 200051828

Select item 2000330726.

An epithelial-mesenchymal transition (EMT) gene signature predicts resistance to erlotinib and PI3K pathway inhibitors and identifies Axl as a novel EMT marker in non-small cell lung cancer.

(Submitter supplied) Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, its potential to predict response to other targeted drugs or chemotherapy has not been well characterized. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
131 Samples

Download data: CEL

Series

Accession:: GSE33072

ID:: 200033072

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000329897.

Expression profiling of lung cancer cell lines (UTSW Lung Panel V2)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13376
69 Samples

Download data: TXT

Series

Accession:: GSE32989

ID:: 200032989

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000320368.

Expression profiling of lung cancer cell lines

(Submitter supplied) Purpose: To determine the 8-week disease control rate (DCR) of sorafenib monotherapy in patients with advanced non-small-cell lung cancer (NSCLC) in the BATTLE trial. Methods: Patients with pre-treated NSCLC, ECOG performance status (PS) 0-2, consented to biopsies to test for biomarker assessment. Sorafenib was given at 400 mg orally twice daily until tumor progression or an unacceptable toxicity. Tumor evaluations were performed at baseline and every 8 weeks. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL10558 GPL6884
222 Samples

Download data: TXT

Series

Accession:: GSE32036

ID:: 200032036

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001216349.

Transcriptome profiling to determine molecular mechanisms of acquired EGFR TKI resistance

(Submitter supplied) The goal of this study was to compare the transcriptome (RNA-seq) of EGFR TKI sensitive NSCLC cells with that of cells with acquired resistance to erlotinib. HCC827 and HCC4006 cells were continuously cultured in erlotinib until erlotinib resistant (ER) variants emerged. All ER variants were negative for T790M. RNA from parental and ER cells was isolated for transcriptomic profiling. RNA-seq analysis reveals that EGFR TKI resistance is associated with a mesenchymal gene expression signature.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
30 Samples

Download data: TSV

Series

Accession:: GSE121634

ID:: 200121634

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20023193810.

Metabolic Reprogramming Driven by IGF2BP3 Promotes Acquired Resistance to EGFR Inhibitors in Non–Small Cell Lung Cancer

(Submitter supplied) Acquired resistance represents a bottleneck for effective molecular targeted therapy in lung cancer. Metabolic adaptation is a distinct hallmark of human lung cancer that might contribute to acquired resistance. In this study, we discovered a novel mechanism of acquired resistance to EGFR tyrosine kinase inhibitors (TKI) mediated by IGF2BP3-dependent cross-talk between epigenetic modifications and metabolic reprogramming through the IGF2BP3–COX6B2 axis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL24676 GPL21290
10 Samples

Download data: XLSX

Series

Accession:: GSE231938

ID:: 200231938

Select item 20011586411.

Notch3-dependent beta-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC

(Submitter supplied) EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin in EGFR TKI resistance has been previously reported however the precise mechanism by which β-catenin activation contributes to EGFR TKI resistance is not clear. Here, we show that EGFR inhibition results in the activation of β-catenin signaling in a Notch3-dependent manner, which facilitates the survival of a subset of cells that we call “adaptive persisters”. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
18 Samples

Download data: CEL

Series

Accession:: GSE115864

ID:: 200115864

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002830312.

An East-Asian polymorphism underlies BCR-ABL mutation-independent resistance to tyrosine kinase inhibitors in chronic myelogenous leukemia

(Submitter supplied) We used massively parallel DNA sequencing of paired-end ditags (DNA-PET) to identify structural genetic factors associated with disease progression and drug-resistance in representative samples from four CML patients and one CML cell line. The functional consequences of our genetic findings were evaluated in primary CML cells and cell lines, and validated in a larger CML cohort. We discovered a novel intronic deletion that correlated with imatinib-resistance, and was subsequently confirmed to be a polymorphism in normal East-Asian, but not African or Caucasian, populations. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by high throughput sequencing

Platforms:: GPL9138 GPL9442
6 Samples

Download data: GFF, TXT

Series

Accession:: GSE28303

ID:: 200028303

PubMed Similar studies SRA Run Selector

Select item 20022300913.

cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other

Platforms:: GPL24676 GPL18573
32 Samples

Download data: TXT

Series

Accession:: GSE223009

ID:: 200223009

PubMed Full text in PMC Similar studies

Select item 20022300714.

Mutational analysis of HCC827 and HCC827-OR cell lines [HCC827OR_WES]

(Submitter supplied) To investigate if there are new genetic mutations occurred within the HCC827 osimertinib resistant cells compared with the parental cells.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
4 Samples

Download data: VCF

Series

Accession:: GSE223007

ID:: 200223007

PubMed Full text in PMC Similar studies

Select item 20022300615.

Gene expression of HCC827 and HCC827-OR cell line [HCC827OR_RNA]

(Submitter supplied) To investigate the abnormal gene expression in Osimertinib Resistance lung cancer cell line, We performed gene expression profiling analysis using data obtained from RNA-seq of HCC827 cell line and HCC827OR cell line.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: TXT

Series

Accession:: GSE223006

ID:: 200223006

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022300516.

Mutational analysis of PC9 and PC9-OR cell lines. [JXQ_WES]

(Submitter supplied) To investigate if there are new genetic mutations occurred within the PC-9 osimertinib resistant cells compared with the parental cells.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
4 Samples

Download data: VCF

Series

Accession:: GSE223005

ID:: 200223005

PubMed Full text in PMC Similar studies

Select item 20022282917.

Gene expression of HCC827 and HCC827-TET2-KO cell line [HCC827_TET2_KO_RNA]

(Submitter supplied) To investigate the influence of TET2 knock-down in lung cancer cell line, We performed gene expression profiling analysis using data obtained from RNA-seq of HCC827 cell line and HCC827-TET2-KO cell line.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: TXT

Series

Accession:: GSE222829

ID:: 200222829

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022282718.

Distribution of genomic 5hmC marks in HCC827 and HCC827-TET2-KO cell line [HCC827_TET2_KO_5hmC]

(Submitter supplied) To investigate the influence of TET2 knock-down in lung cancer cell line, We performed 5hmC landscape analysis using data obtained from 5hmC-seq of HCC827 cell line and HCC827-TET2-KO cell line.