GEO DataSets

(Submitter supplied) We used CRISPR to generate pools of T. gondii mutants in the presence of dihydroartemisinin to identify genes that confer increased or decreased sensitivity to this drug.

Organism:

Toxoplasma gondii; synthetic construct

Type:

Other

Platforms:

GPL15228 GPL16774

13 Samples

Download data: TXT

(Submitter supplied) The emergence of multidrug resistance in Plasmodium falciparum parasites presents a significant obstacle to the malaria elimination agenda. Resistance to piperaquine (PPQ), an important first-line partner drug, has spread across Southeast Asia where it has contributed to widespread treatment failures. The genetic cause of resistance to PPQ is attributable to a novel set of amino acid substitutions in the P. more...

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL15130

13 Samples

Download data: TXT

(Submitter supplied) RNAseq data profiling antimalarial-sensitive P. falciparum piggyBac mutants with and without exposure to low dose of DHA and BTZ.

Organism:

Plasmodium falciparum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21298

16 Samples

Download data: TXT

(Submitter supplied) Evolving resistance to artemisinin-based compounds in SE Asia threatens to derail attempts to control and eliminate malaria. Resistance has been confirmed in western Cambodia, has recently emerged in western Thailand, but is absent from neighboring Laos. Artemisinin resistance results in reduced parasite clearance rates (CR) from the blood following treatment. We used a two-phase approach to identify the genes underlying this ongoing selective event. more...

Organism:

Plasmodium falciparum

Type:

Genome variation profiling by genome tiling array

Platform:

GPL13355

167 Samples

Download data: BASES

(Submitter supplied) A testing association of parasite genotypes with clinical resistance phenotype. Submission of genotypes from all microarray genotyped samples

Organism:

Plasmodium falciparum

Type:

Genome variation profiling by genome tiling array

Platform:

GPL18484

516 Samples

Download data: FTR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL18893

1153 Samples

Download data: GPR

(Submitter supplied) The objective of our study is to characterize gene expression signatures associated with in vivo artemisinin-resistance phenotype in this large-scale genome-wide association study. To achieve this goal, we employed microarray technology to establish the global gene expression profiles of isolates sampled from 1043 patients, of whom after treatment with ACTs (artemisinin combination therapy) displayed differential rates of parasite clearance.

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL18893

110 Samples

Download data: GPR

(Submitter supplied) The objective of our study is to characterize gene expression signatures associated with in vivo artemisinin-resistance phenotype in this large-scale genome-wide association study. To achieve this goal, we employed microarray technology to establish the global gene expression profiles of isolates sampled from 1043 patients, of whom after treatment with ACTs (artemisinin combination therapy) displayed differential rates of parasite clearance.

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL18893

1043 Samples

Download data: GPR

(Submitter supplied) This dataset pertains to a steady-state in vitro transcriptomic profiling of artemisinin-resistant (6A-R, 11C-R) and artemisinin-sensitive (6A, 11C) P. falciparum parasites from 10-20 HPI

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL11248

24 Samples

Download data: GPR

(Submitter supplied) This dataset pertains to a steady-state in vitro transcriptomic profiling of artemisinin-resistant (6A-R, 11C-R) and artemisinin-sensitive (6A, 11C) P. falciparum parasites across its intraerythrocytic life cycle

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL11248

24 Samples

Download data: GPR

(Submitter supplied) This dataset pertains to a microarray-based transcriptomic profiling of artemisinin-resistant (6A-R, 11C-R) and artemisinin-sensitive (6A, 11C) P. falciparum under an an in vitro 4 hr artemisinin challenge (900nM), from 10 - 14 HPI

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL11248

24 Samples

Download data: GPR

(Submitter supplied) The gametocyte transcriptomes were generated in P.falciparum parasites of 3D7 strain after PfHP1 depletion aming to determin the transriptional profiles of sexual stages during the parasites gametocyte development.

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL15130

12 Samples

Download data: GPR