Similar studies for GEO DataSets (Select 200132810) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2001328101.

Gene expression profiles of 4-1BB+PD-1-high, 4-1BB-PD-1-high, and PD-1-int tumor-infiltrating CD8 T cells in hepatocellular carcinoma

(Submitter supplied) We report the gene expression profiles of FACS-sorted 4-1BB+PD-1-high, 4-1BB-PD-1-high, and PD-1-int tumor-infiltrating CD8 T cells in hepatocellular carcinoma.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
15 Samples

Download data: TXT

Series

Accession:: GSE132810

ID:: 200132810

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001328122.

Gene expression profiles of tumor-infiltrating CD8 T cells in hepatocellular carcinoma

(Submitter supplied) We report the gene expression profiles of MACS-sorted tumor-infiltrating CD8 T cells in hepatocellular carcinoma.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
10 Samples

Download data: TXT

Series

Accession:: GSE132812

ID:: 200132812

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001607053.

4-1BB Co-stimulation Further Enhances Anti-PD-1-Mediated Reinvigoration of Exhausted CD39+ CD8 T Cells from Primary and Metastatic sites of Epithelial Ovarian Cancers

(Submitter supplied) 4-1BB Co-stimulation Further Enhances Anti-PD-1-Mediated Reinvigoration of Exhausted CD39+ CD8 T Cells from Primary and Metastatic sites of Epithelial Ovarian Cancers

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28038
9 Samples

Download data: XLSX

Series

Accession:: GSE160705

ID:: 200160705

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001113894.

Gene expression profiles of PD1-high, PD1-intermediate, and PD1-negative tumor-infiltrating CD8 T cells in hepatocellular carcinoma

(Submitter supplied) We report the gene expression profiles of FACS-sorted PD1-high, PD1-intermediate, and PD1-negative tumor-infiltrating CD8 T cells in hepatocellular carcinoma.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
18 Samples

Download data: TSV

Series

Accession:: GSE111389

ID:: 200111389

Select item 2001458965.

PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-15

(Submitter supplied) Blockade of programmed death-1 (PD-1) reinvigorates exhausted CD8+ T cells, resulting in tumor regression in cancer patients. Recently, reinvigoration of exhausted CD8+ T cells following PD-1 blockade was shown to be CD28-dependent in mouse models. Herein, we examined the role of CD28 in anti-PD-1-induced human T-cell reinvigoration using tumor-infiltrating CD8+ T cells (CD8+ TILs) obtained from non-small cell lung cancer patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: CSV

Series

Accession:: GSE145896

ID:: 200145896

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001855666.

Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties III

(Submitter supplied) This study reveals supeior efficiacy of triple combination treatment (TCT) based on anti-PD-(L)1 and anti-4-1BB/OX40 and describes immunological mechanisms underlying synergism between the treatment components

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
27 Samples

Download data: TXT

Series

Accession:: GSE185566

ID:: 200185566

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001811527.

Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL24247
32 Samples

Download data: MTX, TSV

Series

Accession:: GSE181152

ID:: 200181152

PubMed Full text in PMC Similar studies

Select item 2001811508.

Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties II

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE181150

ID:: 200181150

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001811429.

Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties I

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE181142

ID:: 200181142

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012475210.

Gene expression profile of hepatocellular carcinoma with marked immune cell infiltration II

(Submitter supplied) Tumor microenvironmental characteristics using gene expression profiles in hepatocellular carcinoma with marked immune stroma (HCC-IS) compared to conventional hepatocellular carcinoma (C-HCC).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
8 Samples

Download data: TXT

Series

Accession:: GSE124752

ID:: 200124752

PubMed Similar studies

Select item 20012475111.

Gene expression profile of hepatocellular carcinoma with marked immune cell infiltration I

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
206 Samples

Download data: TXT

Series

Accession:: GSE124751

ID:: 200124751

PubMed Similar studies

Select item 20011025112.

Epigenetic profiling of OVA-specific CD8+ TILs from mice treated with control, anti-B7S1, anti-PD-1 or anti-B7S1+anti-PD-1 antibodies

(Submitter supplied) Combinational blockade of B7S1 and PD-1 exhibits stronger anti-tumor efficacy than monotherapies. In order to further understand the mechanisms whereby blockade of B7S1 or PD-1 inhibits tumor growth, we conducted ATAC-seq analysis of OVA-specific CD8+ TILs from E.G7-bearing mice treated with control antibodies, anti-B7S1, anti-PD-1 monotherapy or combinational therapy.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21273
4 Samples

Download data: BW

Series

Accession:: GSE110251

ID:: 200110251

PubMed Similar studies SRA Run Selector

Select item 20011024913.

Global gene expression profile of CD8+ TILs from WT and B7S1 KO mice

(Submitter supplied) B7S1 negatively regulates T cells and its expression correlates with poor prognosis of cancer patients. In order to understand how B7S1 signaling contributes to dysfunction of CD8+ T cell in the TME, we conducted transcriptional analysis of OVA-specific CD8+ TILs and different TIL subsets from E.G7-bearing WT and B7S1 KO mice (Day 21).

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL21103
15 Samples

Download data: TXT

Series

Accession:: GSE110249

ID:: 200110249

PubMed Similar studies SRA Run Selector

Select item 20011463114.

Tumor-resident memory-like CD8 T cells represent an essential cellular target for cancer immunotherapy

(Submitter supplied) Persistent exposure to high levels of antigen results in the progressive exhaustion of T cells and has been thought to preclude the formation of memory. In contrast to the latter assumption, we show here that tumor-specific CD8 T cells residing in the tumor microenvironment include a Tcf1 expressing sub population that has key characteristics of central memory cells, lack an effector cell signature but display hallmarks of exhausted T cells, including the expression co-inhibitory receptors such as PD1. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
11 Samples

Download data: TXT

Series

Accession:: GSE114631

ID:: 200114631

PubMed Similar studies SRA Run Selector

Select item 20007991915.

Gene expression of dysfunctional CD8+ T cells from the tumor microenvironment

(Submitter supplied) Although the presence of tumor-infiltrating lymphocytes (TILs) indicates an endogenous anti-tumor response, immune regulatory pathways can subvert the effector phase and enable tumor escape. Negative regulatory pathways include extrinsic suppression mechanisms but also a T cell-intrinsic dysfunctional state. A more detailed study has been hampered by a lack of cell surface markers defining dysfunctional TILs, and it is clear that PD-1 alone is not sufficient. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
8 Samples

Download data: TXT

Series

Accession:: GSE79919

ID:: 200079919

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014816216.

Dual Relief of T-Lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies

(Submitter supplied) Although understanding of T-cell exhaustion is widely based on mouse models, its analysis in cancer patients could provide clues indicating tumor sensitivity to immune checkpoint blockade (ICB). Data suggests a role for costimulatory pathways, particularly CD28, in exhausted T-cell responsiveness to PD-1/PD-L1 blockade. Here, we used single-cell transcriptomic, phenotypic, and functional approaches to dissect the relation between CD8+ T-cell exhaustion, CD28 costimulation, and tumor specificity in head and neck, cervical, and ovarian cancers. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
4 Samples

Download data: TSV

Series

Accession:: GSE148162

ID:: 200148162

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013761017.

Whole genome transcriptome profiling identifies TIGIT as a regulator of T cell exhaustion in liver cancer

(Submitter supplied) PD-1 checkpoint inhibition has shown promising results in patients with hepatocellular carcinoma, inducing objective responses in approximately 20% of the treated patients. The role of other co-inhibitory molecules and their individual contribution to T cell dysfunction in liver cancer, however, remain largely elusive. Here we perform for the first time a comprehensive mRNA profiling of CD8 T cells in a murine model of autochthonous liver cancer by comparing the whole genome transcriptome of naive, functional effector and exhausted, tumor-specific CD8 T cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19096
11 Samples

Download data: TXT

Series

Accession:: GSE137610

ID:: 200137610

Select item 20017240018.

Non-Terminally Exhausted Tumor-Resident Memory HBV-specific T Cell Responses Correlate with Relapse-Free Survival in Hepatocellular Carcinoma

(Submitter supplied) Hepatocellular carcinoma (HCC) often develops following chronic hepatitis B virus (HBV) infection and responds poorly to immune checkpoint blockade. Here we examined the antigen specificities of HCC-infiltrating T cells and their relevance to tumor control. Using highly multiplexed peptide-MHC tetramer staining of unexpanded cells from blood, liver and tumor tissues from 46 HCC patients, we detected 91 different antigen-specific CD8+ T cell populations targeting HBV, neoantigen, tumor-associated and disease-unrelated antigens. more...