Similar studies for GEO DataSets (Select 200123145) - GEO DataSets

(Submitter supplied) Comparison of the gene expression profiles of adult human brain samples from frontal cortical regions, including samples from young, middle aged, normal aged.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5204
Platform:: GPL570
41 Samples

Download data: CEL

Series

Accession:: GSE53890

ID:: 200053890

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 52045.

Age effect on normal adult brain: frontal cortical region

Analysis of postmortem neuropathologically normal brain samples from the frontal cortical regions of young, middle aged, normal aged and extremely aged adults. Results provide insight into molecular mechanisms of aging in frontal cortical regions of the brain.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 age, 2 gender sets

Platform:: GPL570
Series:: GSE53890
41 Samples

Download data: CEL

DataSet

Accession:: GDS5204

ID:: 5204

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2002444936.

RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans

(Submitter supplied) The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasis of RNA. However, the functional significance of RNA helicases in aging has not been explored. Here, we report that a large fraction of RNA helicases regulate the lifespan ofCaenorhabditis elegans. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18245
8 Samples

Download data: TXT

Series

Accession:: GSE244493

ID:: 200244493

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Select item 2001155317.

Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans

(Submitter supplied) Purpose: We found that mutations in microtubule regulating factors lead to altered lifespan. In order to understand the mechnaisms, we carried out RNA-seq analyses to identify genes with differential expression in microtubule regulator mutants.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24892
15 Samples

Download data: TXT

Series

Accession:: GSE115531

ID:: 200115531

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001499448.

Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity (RNA-seq)

(Submitter supplied) Transcriptome-based drug screening is emerging as a powerful tool to identify geroprotective compounds to intervene in age-related disease. We hypothesized that, by mimicking the transcriptional signature of the highly conserved longevity intervention of FOXO3 (daf-16 in worms) overexpression, we could identify and repurpose compounds with similar downstream effects to increase longevity. Our in silico screen, utilizing the LINCS transcriptome database of genetic and compound interventions, identified several FDA-approved compounds that activate FOXO downstream targets in mammalian cells. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22765
8 Samples

Download data: CSV

Series

Accession:: GSE149944

ID:: 200149944

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Select item 2001238629.

Loss of miR-83 extends lifespan and affects target gene expression in an age-dependent manner in Caenorhabditis elegans

(Submitter supplied) We have identified a role of the C. elegans miR-83 in regulating lifespan. mir-83 mutants exhibit an extended lifespan, and its overexpression is sufficient to decrease the prolonged lifespan of the mutants. We observed an upregulation in the expression of sets of miR-83 targets in young mir-83 mutant adults. However, in older mir-83 mutant adults, a different set of genes are upregulated. In vivo assays show that miR-83 regulates expression of a number of targets, including din-1, spp-9 and col-178. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18245
8 Samples

Download data: XLSX

Series

Accession:: GSE123862

ID:: 200123862

PubMed Similar studies SRA Run Selector

Select item 20003072510.

hcf-1(-) transcriptional profiling

(Submitter supplied) We used microarrays to identify genes regulated by HCF-1 in a daf-16-dependent manner.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL13922
28 Samples

Download data: GPR, TXT

Series

Accession:: GSE30725

ID:: 200030725

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022074411.

Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

(Submitter supplied) Aging and the age-associated decline of the proteome is determined in part through neuronal control of evolutionarily conserved transcriptional effectors, which safeguard homeostasis under fluctuating metabolic and stress conditions by regulating an expansive proteostatic network. We have discovered the Caenorhabditis elegans homeodomain-interacting protein kinase (HPK-1) acts as a key transcriptional effector to preserve neuronal integrity, function, and proteostasis during aging. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18245
6 Samples

Download data: TXT

Series

Accession:: GSE220744

ID:: 200220744

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Select item 20002609412.

Life span-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans

(Submitter supplied) One of the most important issues in the study of aging is to discover compounds with longevity-promoting activity and to unravel their underlying mechanisms. Queen honey bees are continuously fed royal jelly (RJ), and they live more than 10 times longer than hive workers, derived from the same diploid genome, which are fed it only for a short period of time during their larval stages. Therefore, RJ is likely to contain longevity-promoting agents for queens. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL11346
6 Samples

Download data: TXT

Series

Accession:: GSE26094

ID:: 200026094

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Select item 20020038313.

Neuronal HLH-30/TFEB modulates muscle mitochondrial fragmentation to improve thermoresistance in C. elegans

(Submitter supplied) RNA-seq performed for studying transcriptomic changesmodulated by neuronal HLH-30 during heat stress

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13657
24 Samples

Download data: TXT

Series

Accession:: GSE200383

ID:: 200200383

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Select item 20004529214.

In vivo gene expression analysis of C elegans in response to rifampicin

(Submitter supplied) We have discovered rifampicin as a glycation inhibitor, which increases life span in C elegans. In order to understand the mechanism of rifampicin action, microarray analysis was performed to study the changes in gene expression brought about by the drug.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
4 Samples

Download data: CEL

Series

Accession:: GSE45292

ID:: 200045292

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Select item 20018441515.

Transcriptome of insulin signalling associated transcription factor targets

(Submitter supplied) We report the transcritional targets of transcription factor downstream of insulin signalling. We knocked down transcription factors under reduced insulin signalling in Caenorhabditis elegans and did transcriptom analysis. This study identified target genes interaction complexity in analogous genetic and experimental conditions. It aid in gaining insight into the new molecular mechanisms downstream of rIIS

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18245 GPL13776
14 Samples

Download data: XLSX

Series

Accession:: GSE184415

ID:: 200184415

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011416016.

Inter-species genetic regulation of longevity: Δhns E. coli activate C. elegans DAF-16 in distinct ways from IIS

(Submitter supplied) We confirmed that the life span of C. elegans feeding hns mutant E. coli was increased. hns mutant E. coli was found to regulate lifespan of C. elegans through daf-16 activation in C. elegans. It is well known that daf-16 is the transcription factor of the insulin/IGF-1 signaling pathway and it is known to regulate downstream genes such as longevity, stress response, and dauer diapause regulation genes. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19757
8 Samples

Download data: TXT

Series

Accession:: GSE114160

ID:: 200114160

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Select item 20017183617.

Expression data from ferulic acid treated C. elegans

(Submitter supplied) Gene expression in N2 worms treated with 500 μM or 0 μM ferulic acid, at days 5. Effects of ferulic acid in C. elegans gene expression is studied, as our results indicate a lifespan extension effect produced by this molecule. RNA-seq were used to detail the global programme of gene expression underlying the lifespan extension and identified distinct classes of up/down-regulated genes in animals treated with ferulic acid.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13657
2 Samples

Download data: TXT

Series

Accession:: GSE171836

ID:: 200171836

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Select item 20013053318.

Longevity is determined by ETS transcription factors in multiple tissues and diverse species

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17275 GPL19132
85 Samples

Download data

Series

Accession:: GSE130533

ID:: 200130533

PubMed Full text in PMC Similar studies

Select item 20013053219.

Longevity is determined by ETS transcription factors in multiple tissues and diverse species [PntRNAi]

(Submitter supplied) Ageing populations pose one of the main public health crises of our time. Reprogramming gene expression by altering the activities of sequence-specific transcription factors (TF) can ameliorate deleterious effects of age. Here we explore how a circuit of TFs coordinates pro-longevity transcriptional outcomes, which reveals a multi-tissue and multi-species role for an entire protein family: the E-twenty-six (ETS) TFs. more...