Similar studies for GEO DataSets (Select 200117833) - GEO DataSets

Select item 2001178331.

Decoding the regulatory logic of the Drosophila male stem cell system

(Submitter supplied) The importance of the niche to provide regulatory inputs to balance stem cell self-renewal and differentiation has become clear. However, the regulatory interplay between stem cells and their niche at the whole genome level is still poorly understood. To elucidate the mechanisms controlling stem cells and their progenies as they progress through development at the transcriptional level, we recorded the regulatory program of two independent cell lineages in the Drosophila testis. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL6629
16 Samples

Download data: BEDGRAPH, CEL

Series

Accession:: GSE117833

ID:: 200117833

PubMed Similar studies

Select item 2000537092.

The Hox gene Abd-B controls stem cell niche function in the Drosophila testis

(Submitter supplied) Stem cells reside in a specialized microenvironment, called niche, which provides essential signals controlling stem cell behavior. Proper niche architecture is a key for normal stem cell function, yet only few upstream regulators are known. Here we report that the Hox transcription factor Abd-B, active in pre-meiotic spermatocytes, affects niche positioning in the Drosophila testis by regulating integrin localization in differentiated somatic cyst cells. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL6629
4 Samples

Download data: CEL, TXT

Series

Accession:: GSE53709

ID:: 200053709

PubMed Similar studies

Select item 2000689973.

Piwi is a key regulator of both somatic and germline stem cells in the Drosophila testis

(Submitter supplied) The Piwi-piRNA pathway is well known for its germline function, yet its somatic role remains elusive. We show here that Piwi is required autonomously not only for germline stem cell (GSC) but also for somatic cyst stem cell (CySC) maintenance in the Drosophila testis. Reducing Piwi activity in the testis caused defects in CySC differentiation. Accompanying this, GSC daughters expanded beyond the vicinity of the hub but failed to differentiate further. more...

Organism:: Drosophila melanogaster

Type:: Other

Platform:: GPL13304
1 Sample

Download data: TXT

Series

Accession:: GSE68997

ID:: 200068997

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001040494.

poly-A RNA profiling of Drosophila neural stem cells (type I NBs) and GMCs of different ages reveal genes involved in cell fate stabilization

(Submitter supplied) Drosophila melanogaster neural stem cells (neuroblasts [NBs]) divide asymmetrically by differentially segregating protein determinants into their daughter cells. Although the machinery for asymmetric protein segregation is well understood, the events that reprogram one of the two daughter cells toward terminal differentiation are less clear. In this study, we use time-resolved transcriptional profiling to identify the earliest transcriptional differences between the daughter cells on their way toward distinct fates. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17275 GPL13304
16 Samples

Download data: TXT, XLSX

Series

Accession:: GSE104049

ID:: 200104049

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000041885.

Drosophila whole testis gene expression

(Submitter supplied) Whole testes were dissected from adult males. RNA from five or six biological replicates were generated and the expression profiles were determined using Affymetrix Drosophila Genechip 1 arrays. Comparisons between the bgcn- and Os+bgcn- groups allowed for the identification of stem cell genes. Keywords: repeat

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS2228
Platform:: GPL72
16 Samples

Download data: CEL

Series

Accession:: GSE4188

ID:: 200004188

Select item 22286.

Testis stem cells

Analysis of testes from bgcn mutants with or without Os ligand overexpression. Testes of bgcn mutants are enriched in transit amplifying cells, while those of Os overexpressing bgcn mutants are enriched in germline and somatic stem cells. Results provide insight into the regulation of stem cells.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 3 genotype/variation sets

Platform:: GPL72
Series:: GSE4188
16 Samples

Download data: CEL

DataSet

Accession:: GDS2228

ID:: 2228

Select item 2000584167.

Gene expression regulated by transcription factor MiT in Drosophila

(Submitter supplied) To understand the role of MiT in Drosophila, we set out to identify critical gene targets by looking at changes in the WT transcriptome induced by either gain or loss of MiT function. Mutant hindgut and malpighian tubules provided loss-of function tissue and nub-Gal4-driven expression of MiT in the wing epithelium was used for gain-of-function. In the wing disc experiment, 543 genes were upregulated by exogenous MiT, and 359 genes were downregulated (>1.4 fold; P value < 0.01). more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL1322
12 Samples

Download data: CEL, XLS

Series

Accession:: GSE58416

ID:: 200058416

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001092588.

Transcriptome analysis of the developing Drosophila ovary

(Submitter supplied) Here we report the transcriptional profile of the developing Drosophila ovaries and transcriptional changes caused by dLmx1a mutation