GEO DataSets

(Submitter supplied) RNA editing diversifies genomically encoded information to expand the complexity of the transcriptome. In ectothermic organisms, including Drosophila and Cephalopoda, where body temperature mirrors ambient temperature, decreases in environmental temperature lead to increases in A-to-I RNA editing and cause amino acid recoding events that are thought to be adaptive responses to temperature fluctuations. more...

Organism:

Ictidomys tridecemlineatus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24271 GPL22929

95 Samples

Download data: BED, GTF, TXT

(Submitter supplied) RNA-seq libraries were prepared from replicate samples (n=5-6) from six physiolocial groups to capture key changes in circannual hibernation.

Organism:

Ictidomys tridecemlineatus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24271 GPL30340

31 Samples

Download data: TSV

(Submitter supplied) Hibernation is an energy-saving strategy adopted by a wide range of mammals to survive highly seasonal or unpredictable environments. Arctic ground squirrels living in Alaska provide an extreme example, with 6-9 months long hibernation seasons when body temperature alternates between levels near 0 C during torpor and 37 C during arousal episodes. Heat production during hibernation is provided, in part, by non-shivering thermogenesis that occurs in large deposits of brown adipose tissue (BAT). more...

Organism:

Mus musculus; Urocitellus parryii

Type:

Expression profiling by array

4 related Platforms

44 Samples

Download data

(Submitter supplied) Hibernation is a seasonally adaptive strategy that allows hibernators to live through extreme cold condition and was viewed as a highly regulated physiological event. In spite of the profound reduction of blood flow to retina, hibernation causes no lasting retinal injury and hibernators show increased tolerance to ischemic insults during hibernation period. To understand the molecular changes of retina in response to hibernation we applied transcriptomic analysis to explore the changes of gene expression of 13-lined ground squirrel retinas during hibernation.

Organism:

Ictidomys tridecemlineatus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22929

10 Samples

Download data: TXT

(Submitter supplied) Comparative transcriptomics of the garden dormouse hypothalamus during early torpor, late torpor and interbout arousal of hibernation

Organism:

Eliomys quercinus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32419

12 Samples

Download data: FASTA, RESULTS

(Submitter supplied) Mammalian hibernators display phenotypes similar to physiological conditions in non-hibernating species under conditions of calorie restriction and fasting, hypoxia, hypothermia, ischemia-reperfusion, and sleep. However, whether or how similarities are also reflected on molecular and genetic levels is unclear. We identified molecular signatures of torpor and arousal in hibernation using a new custom-designed cDNA microarray for the arctic ground squirrel (Urocitellus parryii,) and compared them to molecular signatures of selected phenotypes in mouse. more...

Organism:

Urocitellus parryii

Type:

Expression profiling by array

Platform:

GPL15674

24 Samples

Download data: TXT

(Submitter supplied) Hibernators dramatically lower metabolism to save energy while fasting for months. Prolonged fasting challenges metabolic homeostasis, yet small-bodied hibernators emerge each spring ready to resume all aspects of active life, including immediate reproduction. The liver is the body’s metabolic hub, processing and detoxifying macromolecules to provide essential fuels to brain, muscle and other organs throughout the body. more...

Organism:

Ictidomys tridecemlineatus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24271

26 Samples

Download data: CSV

(Submitter supplied) Hibernators dramatically lower metabolism to save energy while fasting for months. Prolonged fasting challenges metabolic homeostasis, yet small-bodied hibernators emerge each spring ready to resume all aspects of active life, including immediate reproduction. The liver is the body’s metabolic hub, processing and detoxifying macromolecules to provide essential fuels to brain, muscle and other organs throughout the body. more...

Organism:

Ictidomys tridecemlineatus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22974

15 Samples

Download data: CSV

(Submitter supplied) Hibernation enables many species of the mammalian kingdom to overcome periods of harsh environmental conditions. During this physically inactive state metabolic rate and body temperature are drastically downregulated, thereby reducing energy requirements (torpor) also over shorter time periods. Since blood cells reflect the organism's current condition, it was suggested that transcriptomic alterations in blood cells mirror the torpor-associated physiological state. more...

Organism:

Phodopus sungorus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL33631

41 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Urocitellus parryii; Mus musculus

Type:

Non-coding RNA profiling by array; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL7732 GPL9863

6 Samples

Download data: TXT

(Submitter supplied) miRNAs are 19-25 nucleotides long small RNAs now well-known for their regulatory roles in the development and diseases through post-transcriptional and translational controls in a wide range of species. Mammalian hibernation is a physiological process involving dramatic metabolic suppression and cellular reorganization, during which miRNAs may play an important role. We systematically analyzed the miRNAs in the liver of an extreme hibernating species, arctic ground squirrels (Spermophilus parryii), during two stages of hibernation compared to non-hibernating animals by massively parallel Illumina sequencing technology. more...

Organism:

Urocitellus parryii

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL9863

3 Samples

Download data: TXT

(Submitter supplied) miRNAs are 19-25 nucleotides long small RNAs now well-known for their regulatory roles in the development and diseases through post-transcriptional and translational controls in a wide range of species. Mammalian hibernation is a physiological process involving dramatic metabolic suppression and cellular reorganization, during which miRNAs may play an important role. We systematically analyzed the miRNAs in the liver of an extreme hibernating species, arctic ground squirrels (Spermophilus parryii), during two stages of hibernation compared to non-hibernating animals by massively parallel Illumina sequencing technology. more...

Organism:

Mus musculus; Urocitellus parryii

Type:

Non-coding RNA profiling by array

Platform:

GPL7732

3 Samples

Download data: TXT

(Submitter supplied) We hypothesised that induction of a torpor-like state would confer a radioprotective effect given the evidence that hibernation extends survival times in irradiated squirrels compared to active controls. To test this hypothesis, a torpor-like state was induced in zebrafish using melatonin treatment and cold temperature, and radiation exposure was administered twice over the course of 10 days. The protective effects of induced-torpor were assessed via RNA sequencing of mRNA extracted from the GIT. more...

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21741 GPL20828

11 Samples

Download data: TXT, XLSX