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Links from GEO DataSets

Items: 20

1.

CD95L mRNA is toxic to cells [SmallRNA_CD95L.50hrs.Drosha_ko]

(Submitter supplied) >80% of a large number of tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death that is characterized by the simultaneous activation of multiple death pathways and preferentially affects transformed and cancer stem cells. We now show that these si/shRNAs kill cancer cells through canonical RNAi by targeting the 3’UTR of critical survival genes in a unique form of off-target effect. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
4 Samples
Download data: XLSX
Series
Accession:
GSE102779
ID:
200102779

PubMed Full text in PMC Similar studies SRA Run Selector

2.

CD95L mRNA is toxic to cells

(Submitter supplied) >80% of a large number of tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death that is characterized by the simultaneous activation of multiple death pathways and preferentially affects transformed and cancer stem cells. We now show that these si/shRNAs kill cancer cells through canonical RNAi by targeting the 3’UTR of critical survival genes in a unique form of off-target effect. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL21290
12 Samples
Download data: XLSX
Series
Accession:
GSE114425
ID:
200114425

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

3.

CD95/Fas ligand mRNA is toxic to cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL20301
12 Samples
Download data
Series
Accession:
GSE103631
ID:
200103631

PubMed Full text in PMC Similar studies

4.

CD95L mRNA is toxic to cells [SmallRNA.CD95L.50hrs.HeyA8]

(Submitter supplied) >80% of a large number of tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death that is characterized by the simultaneous activation of multiple death pathways and preferentially affects transformed and cancer stem cells. We now show that these si/shRNAs kill cancer cells through canonical RNAi by targeting the 3’UTR of critical survival genes in a unique form of off-target effect. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
4 Samples
Download data: XLSX
Series
Accession:
GSE102780
ID:
200102780

PubMed Full text in PMC Similar studies SRA Run Selector

5.

CD95L mRNA is toxic to cells [SmallRNA_AGOpulldownCD95L_50hrs_HeyA8_CD95KO]

(Submitter supplied) >80% of a large number of tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death that is characterized by the simultaneous activation of multiple death pathways and preferentially affects transformed and cancer stem cells. We now show that these si/shRNAs kill cancer cells through canonical RNAi by targeting the 3’UTR of critical survival genes in a unique form of off-target effect. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL20301
4 Samples
Download data: XLS
Series
Accession:
GSE102777
ID:
200102777

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

6.

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
36 Samples
Download data
Series
Accession:
GSE219226
ID:
200219226

PubMed Full text in PMC Similar studies

7.

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-64]

(Submitter supplied) Analysis of RISC bound short (s)RNAs in a HCT116 Drosha CD95 d.k.o. cell line expressing pLenti-CD95L and various CD95L mutant constructs.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
8 Samples
Download data: TXT
Series
Accession:
GSE219225
ID:
200219225

PubMed Full text in PMC Similar studies

8.

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-63]

(Submitter supplied) Analysis of RISC bound short (s)RNAs in a HCT116 wild-type, Drosha k.o., and Ago 1/2/3 k.o. cells expressing pLenti-CD95L NP or pLenti empty vector.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
12 Samples
Download data: TXT
Series
Accession:
GSE219224
ID:
200219224

PubMed Full text in PMC Similar studies

9.

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-47]

(Submitter supplied) Analysis of RISC bound short (s)RNAs in a HCT116 Drosha CD95 d.k.o. cell line expressing pLenti-CD95L and various CD95L mutant constructs.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
10 Samples
Download data: TXT
Series
Accession:
GSE219223
ID:
200219223

PubMed Full text in PMC Similar studies

10.

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-46]

(Submitter supplied) Analysis of RISC bound short (s)RNAs in a HCT116 wild-type, Drosha k.o., and Dicer k.o. cells expressing pLenti-CD95L NP or pLenti empty vector.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
6 Samples
Download data: TXT
Series
Accession:
GSE219222
ID:
200219222

PubMed Full text in PMC Similar studies

11.

CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes [shL3.shR6.RNAseq.lg]

(Submitter supplied) The death receptor CD95/Fas can be activated by immune cells to kill cancer cells. However, most siRNAs or shRNAs targeting either CD95 or CD95L induce DICE (Death Induced by CD95/CD95L Elimination), a form of cell death in which a combination of different cell death pathways are activated, that is selective for transformed cells, and that preferentially affects cancer stem cells. We now provide evidence that both CD95 and CD95L are part of a network of genes that contain sequences that when expressed as either siRNAs or shRNAs are toxic to cancer cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
16 Samples
Download data: XLSX
Series
Accession:
GSE101234
ID:
200101234

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

12.

CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes [FasLRNAseq.lg]

(Submitter supplied) >80% of a large number of tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death that is characterized by the simultaneous activation of multiple death pathways and preferentially affects transformed and cancer stem cells. We now show that these si/shRNAs kill cancer cells through canonical RNAi by targeting the 3’UTR of critical survival genes in a unique form of off-target effect. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
4 Samples
Download data: XLSX
Series
Accession:
GSE101232
ID:
200101232

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

13.

CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes [shL3.shR6.RNAseq.sm]

(Submitter supplied) The death receptor CD95/Fas can be activated by immune cells to kill cancer cells. However, most siRNAs or shRNAs targeting either CD95 or CD95L induce DICE (Death Induced by CD95/CD95L Elimination), a form of cell death in which a combination of different cell death pathways are activated, that is selective for transformed cells, and that preferentially affects cancer stem cells. We now provide evidence that both CD95 and CD95L are part of a network of genes that contain sequences that when expressed as either siRNAs or shRNAs are toxic to cancer cells. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL20301
16 Samples
Download data: XLSX
Series
Accession:
GSE101183
ID:
200101183

PubMed Full text in PMC Similar studies SRA Run Selector

14.

CD95L derived si- and shRNAs and the CD95L mRNA kill cancer cells through an RNAi mechanism by targeting survival genes [siL3.RNAseq.lg]

(Submitter supplied) We provide evidence that shRNAs and siRNAs derived from CD95 and CD95L preferentially target the 3' UTRs of survival genes culminating in a very robust mode of cell death we call DISE (Death Induced by Survival gene Elimination)
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
8 Samples
Download data: XLSX
Series
Accession:
GSE101167
ID:
200101167

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

15.

CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes [AGOpulldownRNAseq.sm]

(Submitter supplied) >80% of a large number of tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death that is characterized by the simultaneous activation of multiple death pathways and preferentially affects transformed and cancer stem cells. We now show that these si/shRNAs kill cancer cells through canonical RNAi by targeting the 3’UTR of critical survival genes in a unique form of off-target effect. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL20301
8 Samples
Download data: XLSX
Series
Accession:
GSE101166
ID:
200101166

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

16.

CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes [shL1.RNAseq.lg]

(Submitter supplied) We provide evidence that shRNAs and siRNAs derived from CD95 and CD95L preferentially target the 3' UTRs of survival genes culminating in a very robust mode of cell death we call DISE (Death Induced by Survival gene Elimination)
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
4 Samples
Download data: XLSX
Series
Accession:
GSE101157
ID:
200101157

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

17.

CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL20301
56 Samples
Download data
Series
Accession:
GSE87817
ID:
200087817

PubMed Full text in PMC Similar studies

18.

Contribution of 6mer seed toxicity to HIV-1 induced cytotoxicity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing
Platforms:
GPL24676 GPL20301
68 Samples
Download data
Series
Accession:
GSE218195
ID:
200218195

PubMed Full text in PMC Similar studies

19.

Contribution of 6mer seed toxicity to HIV-1 induced cytotoxicity (DISE-69)

(Submitter supplied) Analysis of total RNA by RNA seq
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
4 Samples
Download data: XLSX
Series
Accession:
GSE218194
ID:
200218194

PubMed Full text in PMC Similar studies Analyze with GEO2R

20.

Contribution of 6mer seed toxicity to HIV-1 induced cytotoxicity [DISE-56]

(Submitter supplied) Analysis of RISC bound short (s)RNAs in cells infected with HIV-1 reveals a contribution of 6mer seed toxicity to HIV-1 induced cytopathicity
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing; Other
Platform:
GPL20301
18 Samples
Download data: TXT
Series
Accession:
GSE218193
ID:
200218193

PubMed Full text in PMC Similar studies

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