GEO DataSets

(Submitter supplied) The liver is a major site for synthesis, storage and redistribution of carbohydrates, proteins and lipids. In addition, it is well-known that maternal obesity (MO) increases risk of offspring cardiovascular disease (CVD), diabetes and obesity. However, the mechanisms by which the MO intrauterine environment predisposes offspring to CVD and metabolic dysregulation are unknown. The goal of this study was to assess the impact of MO on primate fetal liver and identify underlying molecular mechanisms by which MO increases disease risk. more...

Organism:

Papio hamadryas

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL15440

11 Samples

Download data: FA, XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Papio hamadryas; Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL6947 GPL15440

22 Samples

Download data

(Submitter supplied) The liver is a major site for synthesis, storage and redistribution of carbohydrates, proteins and lipids. In addition, it is well-known that maternal obesity (MO) increases risk of offspring cardiovascular disease (CVD), diabetes and obesity. However, the mechanisms by which the MO intrauterine environment predisposes offspring to CVD and metabolic dysregulation are unknown. The goal of this study was to assess the impact of MO on primate fetal liver and identify underlying molecular mechanisms by which MO increases disease risk. more...

Organism:

Homo sapiens; Papio hamadryas

Type:

Expression profiling by array

Platform:

GPL6947

11 Samples

Download data: TXT

(Submitter supplied) Maternal high-fat diet consumption predisposes to metabolic and liver dysfunction in F1 male and female at young adulthood. Purpose: We used RNA-seq to determine the liver transcriptome of male and female F1 of MO and control fed mothers. Methods: Female Wistar rat mothers ate control (C) or obesogenic (MO) diet from the time they were weaned through breeding at postnatal day (PND) 120, delivery and lactation. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18694

22 Samples

Download data: TXT

(Submitter supplied) Maternal obesity programs the offspring to cardiovascular disease, insulin resistance, and obesity. We sequenced and profiled the cardiac miRNAs that were dysregulated in the hearts of baboon fetuses born to a high fat / high fructose diet fed mothers compared to a regular diet fed mothers.

Organism:

Papio hamadryas

Type:

Non-coding RNA profiling by array

Platform:

GPL16458

11 Samples

Download data: TXT

(Submitter supplied) Maternal diet is associated with the development of metabolism-related and other non-communicable diseases in offspring. Underlying mechanisms, functional profiles, and molecular markers are only starting to be revealed. Here, we explored the physiological and molecular impact of maternal Western-style diet on the liver of male and female offspring. C57BL/6 dams were exposed to either a low fat/low cholesterol diet (LFD) or a Western-style high fat/high cholesterol diet (WSD) for six weeks before mating, as well as during gestation and lactation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4774

Platform:

GPL11533

27 Samples

Download data: CEL

Analysis of livers from PD14 offspring of C57BL/6 dams fed a Western-style high fat/high cholesterol diet (WSD). Maternal diet is associated with the development of metabolism-related diseases in offspring. Results provide insight into molecular impact of maternal WSD on male and female offspring.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 gender, 2 protocol sets

Platform:

GPL11533

Series:

GSE46359

27 Samples

Download data: CEL

(Submitter supplied) The objective was to determine changes in gene expression in baboon fetal livers at 90, 120, 140 and 165 days gestation (dG) due to reduction of feed consumed by dams. Control dams were fed ad libitum throughout the study, while 30% feed reduction (based on feed consumed by controls at the same gestation stage and adujsted for body weight) started at 30 dG for MNR dams. RNA-seq data was analyzed to identify differentially expressed genes and transcript variants across four time points.

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19164

56 Samples

Download data: TXT

(Submitter supplied) We have previously reported that providing a control diet to obese and diabetic mice during the periconceptional/gestation/lactation period, led to a drastic sex-specific shift from susceptibility to resistance to high fat feeding (HFD) in the female offspring. In the present study, we aimed to characterize exhaustively the metabolic phenotype of F1 and F2 sensitive (S1, S2) and resistant (R1, R2) mice and underscore in the liver, muscle and adipose tissue, the transcriptional and epigenetic mechanisms supporting the response to HFD, the trait of resistance/susceptibility and the adaptation across generations. more...

Organism:

Mus musculus; Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL13688

19 Samples

Download data: GPR, TXT

(Submitter supplied) Background & Aims: The influences of the maternal diet during gestation has been suggested to be involved in the development of different aspects of the metabolic syndrome. In our mouse model we characterised the role of maternal western diet in the development of non-alcoholic fatty liver disease (NAFLD) in the offspring. Methods: Female mice were fed either a western (W) or low-fat control (L) semi-synthetic diet before and during gestation and lactation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS5293 GDS5342

Platform:

GPL6887

22 Samples

Download data: TXT

Analysis of liver of C57BL/6J male offspring exposed prenatally to a western-style diet (rich in energy, fat, cholesterol) or a low-fat diet and then a post-weaning low-fat diet. Results provide insight into the role of maternal western diet in the development of liver disease in offspring.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL6887

Series:

GSE44901

11 Samples

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Analysis of liver of C57BL/6J male offspring exposed prenatally to a western-style diet (rich in energy, fat, cholesterol) or a low-fat diet and then a post-weaning western diet. Results provide insight into the role of maternal western diet in the development of liver disease in offspring.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL6887

Series:

GSE44901

11 Samples

Download data

(Submitter supplied) Maternal obesity has long-term effects on offspring metabolic health. Among the potential mechanisms, prior research has indicated potential disruptions in circadian rhythms and gut microbiota in the offspring. To challenge this hypothesis, we implemented a maternal high fat diet regimen before and during pregnancy, followed by a standard diet after birth. Our findings confirm that maternal obesity impacts offspring birth weight and glucose and lipid metabolisms. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

70 Samples

Download data: TXT