GEO DataSets

(Submitter supplied) The present study examines changes in global gene expression patterns and in virulence factor-associated genes in an extended spectrum beta-lactamase (ESBL)-producing UPEC (ESBL019) during the morphologic transitions induced by an ineffective antibiotic and in the presence of human primary bladder epithelial cells. The morphological shifts induced by ineffective antibiotics are associated with significant transcriptional virulence alterations in ESBL-producing UPEC, which may affect survival and persistence in the urinary tract.

Organism:

Escherichia coli; Escherichia coli O157:H7 str. EDL933; Escherichia coli CFT073; Escherichia coli O157:H7 str. Sakai; Escherichia coli str. K-12 substr. MG1655

Type:

Expression profiling by array

Platform:

GPL13359

16 Samples

Download data: TXT

(Submitter supplied) Treatment of urinary tract infections is today a challenge due to the increasing prevalence of multidrug-resistant ESBL-producing uropathogenic Escherichia coli (UPEC). There is an urgent need for new treatment strategies for multidrug-resistant UPEC and preferably with targets that have low potential for development of resistance. Carbon monoxide-releasing molecules (CORMs) are novel and potent antibacterial agents. more...

Organism:

Escherichia coli O157:H7 str. EDL933; Escherichia coli str. K-12 substr. MG1655; Escherichia coli CFT073; Escherichia coli O157:H7 str. Sakai; Escherichia coli

Type:

Expression profiling by array

Platform:

GPL13359

16 Samples

Download data: TXT

(Submitter supplied) To gain further information of the correlation and pathogenisis of UPEC and APEC, the in vivo expression of 152 specific genes in both murine urinary tract infection (UTI) model and chicken challenge model were compared to that of UPEC U17 and APEC E058 grown statically to exponential phase in rich medium, respectively.

Organism:

Escherichia coli

Type:

Expression profiling by array

Platform:

GPL6870

4 Samples

Download data: LSR

(Submitter supplied) We report a transcriptional response in the mouse bladder following exposure to the major flagella filament protein, FliC. The response is shown to encompasses multiple innate immune networks not previously associated with FliC. Additionally, we provide analysis of components of this response that depend on the presence of the known flagellin receptor, TLR5.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

17 Samples

Download data: XLSX