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Links from GEO DataSets

Items: 20

1.

MiR-34a controls proliferation and plasticity of early-progenitors in the normal mammary gland and in breast cancer

(Submitter supplied) The miR-34 is a tumor-suppressor miRNA family involved in various human cancers, including breast. However, the role of such miRNAs in the control of mammary stem cells (MaSCs), early-progenitors and their tumor counterparts, (CSCs) lies largely unexplored. Here, we identified miR-34a as directly regulated by TP53 in primary mouse mammospheres. Expression of miR-34a is induced upon luminal commitment and differentiation and able to inhibit the expansion of the MaSCs/early-progenitor pool in a p53-independent fashion. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
12 Samples
Download data: XLSX
Series
Accession:
GSE99401
ID:
200099401
2.

Gene Expression of murine mammary stem-like cells, HC11: Control vs miRNA206 mimic treatment

(Submitter supplied) MicroRNAs are likely to play pivotal roles in both stem cells and cancer, and are further promising candidates for future therapeutic purposes. To understand the role of miR206 in mammary cell differentiation, we profiled the transcription of mamary stem-like cells, comparing control HC11 cells (unspecific miRNA mimic treated) with HC11 cells transfected with miRNA-206 mimic.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21268
2 Samples
Download data: GPR
Series
Accession:
GSE76251
ID:
200076251
3.

Transcriptome characterization of IFNa response in MaSC and luminal progenitor cells

(Submitter supplied) Transcriptome response to IFNa treatment in MaSC, Luminal progenitor cells were studied. The MaSC, Luminal progenitor cells enriched subpopulations were sorted based on CD24/CD29 expression from mammary epithelial cells of virgin female mice . (Tiede BJ et al., 2009, PLoS ONE 4(11): e8035. doi:10.1371/journal.pone.0008035). The cells were cultured in mammosphere condition in vitro and treated with Ifna for 8 days. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
8 Samples
Download data: TXT
Series
Accession:
GSE93068
ID:
200093068
4.

miR-199a-LCOR axis regulation of mammary gland stem cell and breast cancer stem cell transcriptional programs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
5 related Platforms
46 Samples
Download data: TXT
Series
Accession:
GSE85808
ID:
200085808
5.

LCOR regulates transcription of human mammary epithelial and breast cancer cells

(Submitter supplied) Normal human mammary epithelial cell (HMLE) and breast cancer MDA-MB-231 cells are engineered to knockdown or enforce expression of variety of LCOR gene products. In addition to wild-type cDNA, functional domain deficient mutants were used to elucidate mechanism of LCOR incorporated transcriptional regulation. The transcriptome profiles were determined and compared.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
12 Samples
Download data: TXT
Series
Accession:
GSE85802
ID:
200085802
6.

Transcriptome profiles of mouse mammary stem cells and progenitor cells 2

(Submitter supplied) MaSC, Luminal progenitor enriched subpopulations were sorted based on CD24/CD29 expression from mammary epithelial cells of virgin female mice . (Tiede BJ et al., 2009, PLoS ONE 4(11): e8035. doi:10.1371/journal.pone.0008035), and the transcirptome profiles were determined and compared.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
10 Samples
Download data: TXT
Series
Accession:
GSE85635
ID:
200085635
7.

microRNA profiles of mouse mammary stem cells and luminal cells

(Submitter supplied) MaSC and luminal enriched subpopulations were sorted based on CD24/CD29 expression from mammary epithelial cells of virgin female mice . (Tiede BJ et al., 2009, PLoS ONE 4(11): e8035. doi:10.1371/journal.pone.0008035), and the microRNA profiles were determined using microRNA array and compared.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL17912
6 Samples
Download data: TXT
Series
Accession:
GSE85634
ID:
200085634
8.

Transcriptome characterization of the mouse Lgr5+_MaSCs

(Submitter supplied) Lgr5 positive and negative MaSC enriched P4 subpopulation were isolated from virgin Lgr5-EGFP-IRES-CreERT2 mice. The transcriptome profiles of the cells are compared to elucidate the molecular mechanism Lgr5+_MaSCs as a more defined MaSCs subpopulation within the P4 (MaSC and basal progenitor enriched popuation).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
6 Samples
Download data: TXT
Series
Accession:
GSE85633
ID:
200085633
9.

miR-199a regulates human mammary epthelial cell function

(Submitter supplied) miR-199a expression was enforced in HMLE cells using lentiviral vector pLEX. The transcriptome profiles changes following miR-199a expression was studied.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
4 Samples
Download data: TXT
Series
Accession:
GSE85629
ID:
200085629
10.

Expression data from freshly isolated mouse mammary luminal cells

(Submitter supplied) The mammary luminal cell compartment is heterogeneous. In adult virgin mice, it contains clonogenic luminal progenitors and non-clonogenic luminal cells expressing estrogen and progesterone receptors that can be discrimated by their cell surface expression of ICAM-1. We have separated ICAM1+ luminal progenitors and ICAM- non-clonogenic luminal cells and analyzed their transcriptomic profiles. After showing that the luminal progenitor population overexpressed Met, Trp53 and numerous p53 target genes, we analyzed how the p53 and Met signaling pathways cooperate to control the function and plasticity of luminal progenitors.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
14 Samples
Download data: CEL
Series
Accession:
GSE122928
ID:
200122928
11.

ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signaling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
20 Samples
Download data: TXT
Series
Accession:
GSE47493
ID:
200047493
12.

Transcriptome profiles of mouse mammary stem cells and progenitor cells

(Submitter supplied) MaSC, Luminal progenitor enriched subpopulations were isolated from virgin and pregnant mice based on using both surface marker or internal reporter transgene (GFP) expression. (Tiede BJ et al., 2009, PLoS ONE 4(11): e8035. doi:10.1371/journal.pone.0008035), and the transcirptome profiles were determined and compared.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
14 Samples
Download data: TXT
Series
Accession:
GSE47419
ID:
200047419
13.

∆Np63 regulates stem cell activity in mammary gland development

(Submitter supplied) MaSC, luminal progenitor enriched subpopulations and total MECs as well, were isolated from both wild type and ∆Np63 KO heterozygous mouse and the transcriptome profiles were determined and compared.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
6 Samples
Download data: TXT
Series
Accession:
GSE47417
ID:
200047417
14.

Gene expression analyses of C/EBPb knockout in stem/progenitor cell populations

(Submitter supplied) CCAAT/enhancer binding protein beta (C/EBPb) is a member of a family of highly conserved transcription factors that regulates numerous genes involved in proliferation and differentiation in a variety of tissues. C/EBPb is deregulated in human breast cancer and germline deletion of this gene results in multiple defects in mammary gland development. We hypothesized that C/EBPb regulates mammary stem cell self-renewal, maintenance and/or differentiation through the regulation of multiple target genes that coordinate mammary gland development. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE16380
ID:
200016380
15.

Gene signature of adult mammary stem cells and mammary cancer stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR; Expression profiling by array
Platforms:
GPL1261 GPL2850
41 Samples
Download data: CEL
Series
Accession:
GSE40715
ID:
200040715
16.

Gene signature of adult mammary stem cells and mammary cancer stem cells (RT_PCR)

(Submitter supplied) The Wnt/beta-catenin signalling pathway plays a central role in mammary stem cell homeostasis and in breast cancer. We employed the CD29hiCD24+ cell surface antigens to identify a subpopulation of mammary CSCs from Apc1572T/+, a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-negative breast cancer in man. The MaCSCs are capable of recapitulating tumorigenesis when transplanted at low multiplicities in vivo, and of forming self-renewing organoids in vitro. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL2850
17 Samples
Download data: TXT
Series
Accession:
GSE40704
ID:
200040704
17.

Gene signature of adult mammary stem cells and mammary cancer stem cells (Affymetrix)

(Submitter supplied) The Wnt/beta-catenin signalling pathway plays a central role in mammary stem cell homeostasis and in breast cancer. We employed the CD29hiCD24+ cell surface antigens to identify a subpopulation of mammary CSCs from Apc1572T/+, a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-negative breast cancer in man. The MaCSCs are capable of recapitulating tumorigenesis when transplanted at low multiplicities in vivo, and of forming self-renewing organoids in vitro. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
24 Samples
Download data: CEL
Series
Accession:
GSE40702
ID:
200040702
18.

miR205 Regulates Mammary Gland Development and Stem Cell Self-renewal through YAP and Wnt signaling

(Submitter supplied) Mammary gland development is fueled by stem cell self-renewal and differentiation. External cues from the microenvironment coupled with internal cues such as post-transcriptional regulation exerted by miRNAs regulate stem cell behavior and stem cell fate. We have identified a miR205 regulatory network required for mammary gland morphogenesis and stem cell maintenance. In the postnatal mammary gland, miR205 is predominantly expressed in the basal/stem cell enriched population. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: TXT
Series
Accession:
GSE124364
ID:
200124364
19.

MicroRNA regulations during differentiation of mouse mammary stem cell-like cells

(Submitter supplied) MicroRNAs are likely to play pivotal roles in both stem cells and cancer, and are further promising candidates for future therapeutic purposes. To understand the involvement of microRNAs throughout mammary cell differentiation, and the association between microRNAs, stem cells and cancer we profiled the expression of all known microRNA in different stages of mammary cell differentiation.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL15409
4 Samples
Download data: TXT
Series
Accession:
GSE37054
ID:
200037054
20.

Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

(Submitter supplied) WAP-Cre:Ptenf/f:p53lox.stop.lox_R270H composite mice were generated by genetic crossing. In these mice, Pten is deleted and a R270H p53 mutation in the DNA binding domain is induced upon expression of Cre recombinase in pregnancy-identified alveolar progenitors. Tumors were characterized by histology, marker analysis, various bioinformatics methods, high-throughput (HTP) FDA-drug screen as well as orthotopic injection to quantify tumor initiating cells (TICs) and tail-vein injection to identify lung-metastasis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
31 Samples
Download data: CEL
Series
Accession:
GSE75989
ID:
200075989
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