Similar studies for GEO DataSets (Select 200098757) - GEO DataSets

Select item 2000987571.

Dysregulated Signalling leads to altered cell migration: an oncogenic basis for the development of CCSK

(Submitter supplied) The oncogenic mechanisms and tumour biology underpinning Clear Cell Sarcoma of Kidney (CCSK), the second commonest paediatric renal malignancy, are poorly understood and currently therapy depends heavily on Doxorubicin with cardiotoxic side-effects. Previously, we characterised the balanced t(10;17)(q22;p13) chromosomal translocation, identified at that time as the only recurrent genetic aberration in CCSK. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL22067
24 Samples

Download data: CEL, CHP

Series

Accession:: GSE98757

ID:: 200098757

Select item 2000027122.

CCSK

(Submitter supplied) Clear cell sarcoma of the kidney (CCSK), the second most common renal tumor in children, poses significant diagnostic challenges. No diagnostic positive markers are available, and the pathogenesis of CCSK remains an enigma. To address these challenges, the gene expression patterns of fourteen CCSKs were compared to fifteen Wilms tumors (WT) and three fetal kidney samples using oligonucleotide arrays. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1282
Platform:: GPL96
35 Samples

Download data

Series

Accession:: GSE2712

ID:: 200002712

Select item 12823.

Clear cell sarcoma of the kidney

Expression profiling of clear cell sarcoma of the kidney (CCSK). Wilms' tumors and fetal kidney control samples also examined. Objective is to reveal diagnostic markers and insight into the pathogenesis of CCSK.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 disease state sets

Platform:: GPL96
Series:: GSE2712
35 Samples

Download data

DataSet

Accession:: GDS1282

ID:: 1282

Select item 2000448474.

DNA methylation analysis of Rhabdoid tumor of the kidney, Clear cell sarcoma of the kidney and Ewing's sarcoma family of tumors

(Submitter supplied) Genome wide DNA methylation profiling of Rhabdoid tumor of the kidney, Clear cell sarcoma of the kidney, Ewing's sarcoma family of tumors and non-neoplastic kidney. The Illumina Infinium HumanMethylation 27 BeadChip was used to obtain DNA methylation profiles across approximately 27000 CpGs . Samples included 3 Rhabdoid tumor of the kidney, 3 Clear cell sarcoma of the kidney, 3 Ewing's sarcoma family of tumor and 3 non-neoplastic kidney.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL8490
12 Samples

Download data: TXT

Series

Accession:: GSE44847

ID:: 200044847

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000499725.

Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin

(Submitter supplied) Gene expression profiling of CCSK in comparison with non-neoplastic foetal and adult kidney

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
32 Samples

Download data: TXT

Series

Accession:: GSE49972

ID:: 200049972

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000462856.

Identification of a novel, recurrent MBTD1-CXorf67 fusion in low-grade endometrial stromal sarcoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by SNP array; Genome variation profiling by genome tiling array

Platforms:: GPL11358 GPL14550
13 Samples

Download data: TXT

Series

Accession:: GSE46285

ID:: 200046285

Select item 2000462847.

Identification of a novel, recurrent MBTD1-CXorf67 fusion in low-grade endometrial stromal sarcoma (aCGH)

(Submitter supplied) Endometrial stromal sarcomas (ESSs) are a genetically heterogeneous group of rare uterine neoplasms that are frequently driven by recurrent gene rearrangements. In conventional low-grade ESSs, JAZF1-SUZ12, PHF1-JAZF1, EPC1-PHF1 and MEAF6-PHF1 chimeric fusions have been reported in > 50% of cases. The recently described t(10;17)(q22;p13) translocation yields YWHAE-FAM22A/B chimeric proteins that are associated with histologically high-grade and clinically more aggressive ESS. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; Genome variation profiling by genome tiling array

Platform:: GPL11358
2 Samples

Download data: TXT

Series

Accession:: GSE46284

ID:: 200046284

Select item 2000457838.

Identification of a novel, recurrent MBTD1-CXorf67 fusion in low-grade endometrial stromal sarcoma (expression)

(Submitter supplied) Endometrial stromal sarcomas (ESSs) are a genetically heterogeneous group of rare uterine neoplasms that are frequently driven by recurrent gene rearrangements. In conventional low-grade ESSs, JAZF1-SUZ12, PHF1-JAZF1, EPC1-PHF1 and MEAF6-PHF1 chimeric fusions have been reported in >50% of cases. The recently described t(10;17)(q22;p13) translocation yields YWHAE-FAM22A/B chimeric proteins that are associated with histologically high-grade and clinically more aggressive ESS. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
11 Samples

Download data: TXT

Series

Accession:: GSE45783

ID:: 200045783

Select item 2000711429.

Identification of differentially expressed miRNAs in drug resistant and drug sensitive breast cancer tissues

(Submitter supplied) To identify miRNAs involved in drug resistance of human breast cancer, a miRNA microarray was performed on 5 cases of drug resistant tissues and 5 cases of drug sensitive tissues.The expression levels of totally 2019 miRNAs in 5 pairs of matched, drug resistant and drug sensitive tissues were examined by microarray. There were 27 differentially expressed miRNAs between drug resistant and drug sensitive tissues were identified of which there were 11 significantly up-regulated while the other 16 were down-regulated in drug resistant tissues compared to drug sensitive tissues. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL20717
10 Samples

Download data: TXT

Series

Accession:: GSE71142

ID:: 200071142

Select item 20007114110.

Gene expression signatures in SPIN1 siRNA- and negative control-transfected breast cancer cell line MCF-7/ADM

(Submitter supplied) To screen potential target genes of SPIN1 in breast cancer, human gene expression microarray was performed to identify differentially expressed mRNAs in SPIN1 siRNA or negative control transfected MCF-7/ADM cells. After transfection with SPIN1 siRNA, 4409 genes were differentially expressed by >2-fold in MCF-7/ADM cells compared with negative control-transfected cells, of which 2413 were significantly downregulated and the other 1996 were upregulated. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16025
2 Samples

Download data: PAIR

Series

Accession:: GSE71141

ID:: 200071141

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007320911.

Gene expression profiling of Wilms tumors

(Submitter supplied) The global gene expression pattern of Wilms tumors in comparison with clear cell sarcoma of the kidney (CCSK) and non-neoplastic fetal and adult kidneys.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
40 Samples

Download data: TXT

Series

Accession:: GSE73209

ID:: 200073209

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007318712.

Aberrant epigenetic regulation in clear cell sarcoma of the kidney (CCSK)

(Submitter supplied) Methylation array analyses of 30 CCSKs in comparison with 18 Wilms tumours and normal non-malignant kidneys (2 foetal kidneys and 6 adult kidneys) revealed CCSK tumour DNA to be globally hypermethylated. Four CCSKs, two WTs, two foetal kidneys and 2 adult kidneys were analysed as technical duplicates on different arrays.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
66 Samples

Download data: TXT

Series

Accession:: GSE73187

ID:: 200073187

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20019600313.

Genomic profiling identifies genes and pathways dysregulated by HEY1-NCOA2 fusion and shed a light on mesenchymal chondrosarcoma tumorigenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
18 Samples

Download data: BW

Series

Accession:: GSE196003

ID:: 200196003

PubMed Full text in PMC Similar studies

Select item 20019600214.

Genomic profiling identifies genes and pathways dysregulated by HEY1-NCOA2 fusion and shed a light on mesenchymal chondrosarcoma tumorigenesis [RNA-seq]

(Submitter supplied) Mesenchymal chondrosarcoma is a rare and often aggressive cancer that accounts for 2-10% of all chondrosarcomas. Genetically, this tumor is characterized by the recurrent HEY1-NCOA2 fusion. However, the oncogenic function of HEY1-NCOA2 fusion in mesenchymal chondrosarcoma remains to be elucidated. We stably transduced HEK293 as well as iPSC-derived mesenchymal stem cells (MSCs) with inducible- expression HEY1, NCOA2 and HEY1-NCOA2 construct, respectively. more...