Similar studies for GEO DataSets (Select 200093365) - GEO DataSets

Select item 2000933651.

Expression level is a key determinant of E2F1-mediated cell fate

(Submitter supplied) Purpose: dose response analysis of E2F1 target genes expression in flow-sorted fractions with increasing amounts of fluorescently labled E2F1 Methods:U2OS pTRIPZ-YFP-ER-E2F1 cells were grown in full serum-containing growth medium and treated with 500 ng/ml doxycycline for 48 hours followed by addition of 90 nM OHT for an additional 20 hours. Cells from different YFP fractions were sorted by flow cytometry. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
5 Samples

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Series

Accession:: GSE93365

ID:: 200093365

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000450522.

Non-steroidal Anti-inflammatory Drugs Decrease E2F1 Expression and Inhibit Cell Growth in Ovarian Cancer Cells

(Submitter supplied) Epidemiological studies have shown that the regular use of non-steroidal anti-inflammatory (NSAIDs) drugs is associated with a reduced risk of various cancers. In addition, in vitro and experiments in mouse models have demonstrated that NSAIDs decrease tumor initiation and/or progression of several cancers. However, there are limited preclinical studies investigating the effects of NSAIDs in ovarian cancer. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5353
Platform:: GPL6104
9 Samples

Download data: TXT

Series

Accession:: GSE45052

ID:: 200045052

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 53533.

Non-steroidal anti-inflammatory drug treatment effect on serous ovarian adenocarcinoma cell lines

Analysis of ovarian adenocarcinoma cell lines HEY, OVCAR5 and UCI-101 treated 24h with NSAIDs diclofenac or indomethacin (300mM). NSAID drugs associated with a reduced risk of various cancers. Results provide insight into molecular pathways mediating effects of NSAID treatment in ovarian cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 agent, 3 cell line sets

Platform:: GPL6104
Series:: GSE45052
9 Samples

Download data

DataSet

Accession:: GDS5353

ID:: 5353

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001781154.

Synergistic chemical combination for cell cycle restoration in senescent cells via FoxM1 and E2F1 activation

(Submitter supplied) Cellular senescence wreaks defects in the aging organism. In this study, we co-treated two chemicals: rho-associated protein kinase (ROCK) inhibitor (Y-27632) and ataxia telangiectasia mutated (ATM) inhibitor (KU-60019) to overcome senescence more efficaciously, these two chemicals are already revealed to have senomorphic effects, suppressing senescent phenotypes. We find out that cocktail treatment synergistically alleviates diverse senescent phenotypes in senescent human dermal fibroblast cells. more...